Gated entry into the ciliary compartment.
Ann Arbor, United States. In Cell Mol Life Sci, Nov 2015
Specifically, nucleoporins of the CPC limit the diffusional entry of cytosolic proteins in a size-dependent manner and enable the active transport of large molecules and complexes via targeting signals, importins, and the small G protein Ran.
Universal allosteric mechanism for Gα activation by GPCRs.
Cambridge, United Kingdom. In Nature, Sep 2015
Comparison of Gα with the small G protein Ras reveals how the evolution of short segments that undergo disorder-to-order transitions can decouple regions important for allosteric activation from receptor binding specificity.
Crossroads of PI3K and Rac pathways.
Torino, Italy. In Small Gtpases, 2014
PI3Ks are lipid kinases that produce phosphorylated lipids which, in turn, transduce extracellular cues within the cell, while Rac is a small G protein that impacts on actin organization.