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RAB, member of RAS oncogene family-like 2B

The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is located within a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: Cryptic, Tec, BRD1, Rab5, SET
Papers on RABL2B
[Global gene expression responses to Iodine-125 radiation in three human gastric cancer cell lines].
Xu et al., Kunming, China. In Zhonghua Wai Ke Za Zhi, 2014
Four genes, TRAF3IP2-AS1, SDC1, RABL2B and NOM, were found having at least 2-fold difference in expression (P < 0.05) , and the gene expression alteration was confirmed by qRT-PCR.
Constant splice-isoform ratios in human lymphoblastoid cells support the concept of a splico-stat.
Platzer et al., Jena, Germany. In Genetics, 2011
Here we demonstrate that five human transcription units (WT1, NOD2, GNAS, RABL2A, RABL2B) have constant splice-isoform ratios in genetically diverse lymphoblastoid cell lines independent of the type of alternative splicing (exon skipping, alternative donor/acceptor, tandem splice sites) and gene expression level.
Fulminant hepatic failure requiring liver transplantation in 22q13.3 deletion syndrome.
Haaf et al., Mainz, Germany. In Am J Med Genet A, 2010
--> qter; including approximately 55 genes; from NUP50 to RABL2B) and in the previous patient a 1.535 Mb deletion (22q13.32
Analysis of relative gene dosage and expression differences of the paralogs RABL2A and RABL2B by Pyrosequencing.
Huse et al., Jena, Germany. In Gene, 2010
In human samples no deviations of the euploid genomic state could be detected indicating that 22q13 microdeletions involving RABL2B are rare.
Chromosome 22q13.3 deletion syndrome with a de novo interstitial 22q13.3 cryptic deletion disrupting SHANK3.
Drunat et al., Bondy, France. In Eur J Med Genet, 2009
Among the three genes in the minimal critical region (from the centromere to the telomere: SHANK3, ACR and RABL2B), the defect in the SHANK3 gene is considered to be the cause of the neurobehavioral symptoms.
FISH-mapping of a 100-kb terminal 22q13 deletion.
Nordenskjöld et al., Stockholm, Sweden. In Hum Genet, 2002
ACR and RABL2B are deleted and proSAP2 is disrupted.
The evolutionary origin of human subtelomeric homologies--or where the ends begin.
Ledbetter et al., Chicago, United States. In Am J Hum Genet, 2002
These paralogous regions share large continuous homologies and contain three genes: RABL2B, forkhead box D4, and COBW-like.
Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13.
McDermid et al., Edmonton, Canada. In Genomics, 1999
RABL2A and RABL2B differ by three conservative amino acid changes over a total of 228 residues.
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