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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Kinesin family member 20A

Rabkinesin-6, RAB6KIFL, MKLP2, KIF20A
Top mentioned proteins: Rab6, Eg5, HAD, Aurora, CAN
Papers on Rabkinesin-6
Cell culture density affects the proliferation activity of human adipose tissue stem cells.
Yoo et al., Seoul, South Korea. In Cell Biochem Funct, Feb 2016
Furthermore, expression of proliferation-associated genes, such as CDC45L, CDC20A and KIF20A, in P4 AT-MSCs was higher in CC1 than in CC2, and this difference was also observed in P12 AT-MSCs.
Identification of genes associated with osteoarthritis by microarray analysis.
Zhang et al., Shanghai, China. In Mol Med Report, Oct 2015
The top protein domain was IPR001752: Kinesin motor region involving three genes (KIF2C, KIF11 and KIF20A).
Genistein and cancer: current status, challenges, and future directions.
Nabavi et al., Avellino, Italy. In Adv Nutr, Jul 2015
Targeting caspases, B cell lymphoma 2 (Bcl-2)-associated X protein (Bax), Bcl-2, kinesin-like protein 20A (KIF20A), extracellular signal-regulated kinase 1/2 (ERK1/2), nuclear transcription factor κB (NF-κB), mitogen-activated protein kinase (MAPK), inhibitor of NF-κB (IκB), Wingless and integration 1 β-catenin (Wnt/β-catenin), and phosphoinositide 3 kinase/Akt (PI3K/Akt) signaling pathways may act as the molecular mechanisms of the anticancer, therapeutic effects of genistein.
Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance.
Lam et al., London, United Kingdom. In Oncogene, Jun 2015
We also demonstrate that FOXM1 regulates the expression of the microtubulin-associated kinesin KIF20A at the transcriptional level directly through a Forkhead response element (FHRE) in its promoter.
Downregulated CXCL12 expression in mesenchymal stem cells associated with severe aplastic anemia in children.
Lee et al., T'ai-chung-shih, Taiwan. In Ann Hematol, 2015
Fourteen genes (POLE2, HGF, KIF20A, TK1, IL18R1, KITLG, FGF18, RRM2, TTK, CXCL12, DLG7, TOP2A, NUF2, and TYMS), which are related to DNA synthesis, cytokines, or growth factors, were significantly downregulated.
KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells.
Saibara et al., Kōchi, Japan. In Neoplasia, 2014
Here, we report that the motor kinesin protein KIF20A promoted the motility and invasiveness of pancreatic cancer cells through transporting the RNA-binding protein IGF2BP3 and IGF2BP3-bound transcripts toward cell protrusions along microtubules.
XI-006 induces potent p53-independent apoptosis in Ewing sarcoma.
Callen et al., Adelaide, Australia. In Sci Rep, 2014
RNA expression analysis revealed that the mechanism of action of XI-006 could be accredited to the inhibition of cell division and cycle regulators such as KIF20A and GPSM2.
Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5.
Hagedorn et al., Talence, France. In Oncotarget, 2013
Here we report induction of Eg5 and four other mitotic kinesins including KIF20A/Mklp2 upon stimulation of in vivo angiogenesis with vascular endothelial growth factor-A (VEGF-A).
Combinatorial measurement of CDKN1A/p21 and KIF20A expression for discrimination of DNA damage-induced clastogenicity.
Uehara et al., Toyonaka, Japan. In Int J Mol Sci, 2013
The network, however, also included kinesin family member 20A (KIF20A) downregulated by treatment with all the DNA damage-inducing clastogens.
KIF20A regulates porcine oocyte maturation and early embryo development.
Rui et al., Nanjing, China. In Plos One, 2013
KIF20A (Kinesin-like family member 20A), also called mitotic kinesin-like proteins 2 (MKLP2), is a mammalian mitotic kinesin-like motor protein of the Kinesin superfamily proteins (KIFs), which was originally involved in Golgi apparatus dynamics and thought to essential for cell cycle regulation during successful cytokinesis.
Phase I clinical trial of multiple-peptide vaccination for patients with advanced biliary tract cancer.
Yamamoto et al., Tokyo, Japan. In J Transl Med, 2013
Three HLA-A*2402 restricted epitope peptides-cell division cycle associated 1 (CDCA1), cadherin 3 (CDH3) and kinesin family member 20A (KIF20A)-were administered subcutaneously, and the adverse events and immune response were assessed.
Immunological responses to a multi-peptide vaccine targeting cancer-testis antigens and VEGFRs in advanced pancreatic cancer patients.
Yamamoto et al., Tokyo, Japan. In Oncoimmunology, 2013
Each patient was vaccinated with HLA-A*2402-restricted peptides derived from the CT antigens kinesin family member 20A (KIF20A) and cell division cycle-associated 1 (CDCA1) as well as from VEGFR1 and VEGFR2 subcutaneously once a week, and disease progression was evaluated up to 6 mo later.
MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation.
Sun et al., Nanjing, China. In Reprod Biol Endocrinol, 2012
Numerous proteins contribute to these processes, but it is unknown whether MKlp2 (mitotic kinesin-like protein 2; also called KIF20A), a microtubule-associated protein that regulates cytokinesis during mitosis, is involved in oocyte maturation.
Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens.
Nishimura et al., Kumamoto, Japan. In Plos One, 2012
BM-DC-based immunization of KIF20A494-517 peptide from another TAA KIF20A, with an almost identical HLA-binding core amino acid sequence to mouse ortholog, successfully induced Th-cell responses in Tgm.
Cytokinesis and cancer: Polo loves ROCK'n' Rho(A).
Xu et al., Beijing, China. In J Genet Genomics, 2010
We review current understandings of the interplay between Plk1, RhoA proteins and other proteins (e.g., NudC, MKLP2, PRC1, CEP55) involved in cytokinesis, with particular emphasis of its clinical implications in cancer.
Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex.
Mayer et al., Konstanz, Germany. In Curr Biol, 2009
Data demonstrate that Mklp2 and the chromosomal passenger complex mutually depend on each other for microtubule midzone localization, and that the association between the CPC and Mklp2 is negatively regulated by Cdk1.
Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.
Nakamura et al., Tokyo, Japan. In Cancer Res, 2005
Collaboration of RAB6KIFL and disc large homologue 5 is likely to be involved in pancreatic cancer.
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.
Barr et al., Martinsried, Germany. In J Cell Biol, 2004
Relocation of the Aurora B/INCENP/survivin passenger protein complex requires KIF20A (MKlp2).
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.
Barr et al., Martinsried, Germany. In J Cell Biol, 2003
KIF20A (MKlp2) is required for targeting of the polo like kinase 1 during anaphase and telophase cells.
The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C.
Hayashi et al., Tokyo, Japan. In Int J Mol Med, 2003
This gene is not involved in Charcot-Marie-Tooth disease.
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