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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

RAB7A, member RAS oncogene family

Rab7, Dp71, alpha-DG
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rab5, CAN, V1a, CD45, HAD
Papers using Rab7 antibodies
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo
Into Takeshi et al., In Cellular and Molecular Life Sciences, 2009
... polyclonal antibody (Cell Signaling Technology; 5202), anti-GFP rabbit monoclonal antibody (Cell Signaling Technology; 2956) and anti-Rab7 rabbit monoclonal antibody (Cell Signaling Technology; 9367) ...
Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1.
Rey Félix A., In PLoS Pathogens, 2006
... Human CLCa, Cav1, and Rab7 genes were amplified by RT-PCR from total RNA derived from HeLa cells, and subcloned into pEGFP-N1 or pEGFP-C1 plasmids (Clontech, Mountain View, USA) ...
Photobleaching techniques to study mobility and molecular dynamics of proteins in live cells: FRAP, iFRAP and FLIP
Enrich Carlos et al., In Traffic (Copenhagen, Denmark), 2004
... Mouse anti-myc (9E10), rabbit anti-Rab5, rabbit anti-Rab7 and mouse anti-HRas were from Santa Cruz Biotechnology.
Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics study.
Ausubel Frederick M., In PLoS Pathogens, 2004
... (Abgent, San Diego, CA); Alexa 647-conjugated phalloidin (Molecular Probes, Carlsbad, CA); rabbit anti-Rab4 antibody, rabbit anti-Rab7 antibody (Santa Cruz Biotechnology, Santa Cruz, CA); mouse ...
Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape
Neefjes Jacques et al., In The Journal of Cell Biology, 2004
... ), mouse monoclonal anti-EEA1 (BD), rabbit anti-Rab7 and rabbit anti-HA epitope tag (Santa Cruz Biotechnology, Inc.), rabbit anti–human protein ...
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Papers on Rab7
Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.
Neefjes et al., Utrecht, Netherlands. In J Biol Chem, Jan 2016
We show that core interactions within CORVET and HOPS are largely conserved but that the membrane-targeting module in HOPS has significantly changed to accommodate binding to mammalian-specific RAB7 interacting lysosomal protein (RILP).
Integrin αVβ5-mediated Removal of Apoptotic Cell Debris by the Eye Lens and Its Inhibition by UV Light Exposure.
Kantorow et al., Boca Raton, United States. In J Biol Chem, Jan 2016
Using high throughput RNA sequencing and bioinformatics analysis, we establish that lens epithelial cells express members of the integrin αVβ5-mediated phagocytosis pathway and that internalized cell debris co-localizes with αVβ5 and with RAB7 and Rab-interacting lysosomal protein that are required for phagosome maturation and fusion with lysosomes.
Phosphatidylinositol 3,5-bisphosphate-rich membrane domains in endosomes and lysosomes.
Fujimoto et al., Nagoya, Japan. In Traffic, Dec 2015
In HeLa cells, PtdIns(3,5)P2 was significantly enriched in the vesicular domain of RAB5- and RAB7-positive endosome/lysosomes of the tubulo-vesicular morphology.
The activation of KSHV lytic cycle blocks autophagy in PEL cells.
Cirone et al., Roma, Italy. In Autophagy, Dec 2015
The autophagic block correlates with the downregulation of RAB7, whose silencing with specific siRNA results in an autophagic block in the same cells.
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth.
Stenmark et al., Oslo, Norway. In Nature, May 2015
Here we show in human and rat cell lines that protrudin, an ER protein that promotes protrusion and neurite outgrowth, forms contact sites with late endosomes (LEs) via coincident detection of the small GTPase RAB7 and phosphatidylinositol 3-phosphate (PtdIns(3)P).
Plant vacuolar trafficking driven by RAB and SNARE proteins.
Ueda et al., In Curr Opin Plant Biol, 2014
In this review, we summarize recent findings on SNARE proteins and RAB GTPases mediating vacuolar transport in plants, especially focusing on the functions and regulation of two distinct trans-SNARE complexes and RAB5 and RAB7 in multiple vacuolar trafficking pathways.
Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages.
Kumar et al., New Delhi, India. In Sci Rep, 2014
We show that the maturation of Mtb-containing autophagosomes into autolysosomes required recruitment of the late endosome marker RAB7, forming the intermediate compartment amphisomes.
RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.
Soengas et al., Madrid, Spain. In Cancer Cell, 2014
Here, we report an inherent dependency of melanoma cells on the small GTPase RAB7, identified within a lysosomal gene cluster that distinguishes this malignancy from over 35 tumor types.
C-Terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells.
Lovejoy et al., Toronto, Canada. In Neuroscience, 2012
Our data provides novel evidence that functionally links the teneurin and dystroglycan systems and provides new insight into the molecular mechanisms by which TCAP-1 regulates cytoskeletal dynamics in hippocampal neurons
Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on α-dystroglycan.
Oka et al., Kyoto, Japan. In J Biol Chem, 2012
novel role for HNK-1ST as a tumor suppressor controlling the functional glycans on alpha-DG and the importance of sulfate transfer in the glycosylation of alpha-DG.
Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth.
Brophy et al., Edinburgh, United Kingdom. In J Neurosci, 2012
Cajal band appositions contain a dystroglycan complex that includes periaxin and dystrophin-related protein (Drp)2.
Glycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases.
Live et al., Bethesda, United States. In J Biol Chem, 2012
one form of glycosylation can influence another form of glycosylation in alpha-DG and suggest that in the absence of proper O-mannosylation, as is associated with certain forms of muscular dystrophy
Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7.
Barsky et al., Reno, United States. In Mol Cancer Res, 2012
Data indicate that Rab7 siRNA knockdown causes increased E-cadherin.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Lyden et al., New York City, United States. In Nat Med, 2012
RAB1A, RAB5B, RAB7 and RAB27A, regulators of membrane trafficking and exosome formation, were highly expressed in melanoma cells.
O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding.
Campbell et al., Iowa City, United States. In Science, 2010
study identified phosphorylated O-mannosyl glycan on mucin-like domain of alpha-DG, which was required for laminin binding; mice with myodystrophy, commonly have defects in a postphosphoryl modification of this phosphorylated O-linked mannose
Rab7 and the CMT2B disease.
Bucci et al., Lecce, Italy. In Biochem Soc Trans, 2009
Four missense mutations in the rab7 gene have been identified as causative of the disease.
Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction.
Kunz, Lausanne, Switzerland. In Virology, 2009
Ten years ago, the first cellular receptor for the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and the highly pathogenic Lassa virus (LASV) was identified as alpha-dystroglycan (alpha-DG), a versatile receptor for proteins of the extracellular matrix (ECM).
Functional diversity of dystroglycan.
Brancaccio et al., Roma, Italy. In Matrix Biol, 2009
Such functional promiscuity can be in part explained when considering the multiple domain organization of the two DG subunits, the extracellular alpha-DG and the transmembrane beta-DG, that has been largely scrutinized, but only in part unraveled, exploiting a variety of recombinant and transgenic approaches.
LARGE can functionally bypass alpha-dystroglycan glycosylation defects in distinct congenital muscular dystrophies.
Campbell et al., Iowa City, United States. In Nat Med, 2004
Several congenital muscular dystrophies caused by defects in known or putative glycosyltransferases are commonly associated with hypoglycosylation of alpha-dystroglycan (alpha-DG) and a marked reduction of its receptor function.
Charcot-Marie-Tooth Neuropathy Type 2
Bird, Seattle, United States. In Unknown Journal, 1998
The 18 genes in which mutation is known to cause CMT2 subtypes are KIF1B (CMT2A1), MFN2 (CMT2A2), RAB7A (formerly RAB7) (CMT2B), LMNA (CMT2B1), MED25 (CMT2B2), TRPV4 (CMT2C), GARS (CMT2D), NEFL (CMT2E/1F), HSPB1 (CMT2F), MPZ (CMT2I/J), GDAP1 (CMT2H/K), HSPB8 (CMT2L), AARS (CMT2N), DYNC1H1 (CMT2O), LRSAM1 (CMT2P), IGHMBP2 (CMT2S), DNAJB2 (CMT2T), and MARS (CMT2U).
More papers using Rab7 antibodies
The Lens Organizes the Anterior Segment: Specification of Neural Crest Cell Differentiation in the Avian Eye
Beebe David C et al., In BMC Cell Biology, 1999
... anti-β-tubulin were from Cell Signaling Technology (Danvers, MA), anti-Smad4, Smad6, Smad7, SARA, c-Ski, Rab5B and Rab7 were from Santa Cruz Biotechnology (Santa Cruz, CA), anti-EEA1 ...
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