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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

RAB32, member RAS oncogene family

Rab32, RABRP1
Small GTP-binding proteins of the RAB family, such as RAB32, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Aug 2009] (from NCBI)
Top mentioned proteins: Rab5, small GTP-binding protein, tyrosinase, CAN, TRPC1
Papers on Rab32
RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.
Ohbayashi et al., Tsukuba, Japan. In J Biol Chem, Feb 2016
Two cell type-specific Rab proteins, Rab32 and Rab38 (Rab32/38), have been proposed as regulating the trafficking of melanogenic enzymes, including tyrosinase and tyrosinase-related protein 1 (Tyrp1), to melanosomes in melanocytes.
Analysis of inflammasomes and antiviral sensing components reveals decreased expression of NLRX1 in HIV-positive patients assuming efficient antiretroviral therapy.
Cossarizza et al., Reggio nell'Emilia, Italy. In Aids, Oct 2015
By RT-PCR, using peripheral blood mononuclear cells (PBMCs), we quantified the mRNA expression of 16 genes involved in inflammasome activation and regulation (AIM2, NAIP, PYCARD, CASP1, CASP5, NLRP6, NLRP1, NLRP3, TXNIP, BCL2, NLRC4, PANX1, P2RX7, IL-18, IL-1β, SUGT1) and eight genes involved in IMS (MFN2, MFN1, cGAS, RIG-I, MAVS, NLRX1, RAB32, STING).
Rab32 is essential for maintaining functional acidocalcisomes, and for growth and infectivity of Trypanosoma cruzi.
Docampo et al., Athens, United States. In J Cell Sci, Jul 2015
Expression of dominant-negative mutants of the CVC-located small GTPase Rab32 (TcCLB.506289.80)
A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division.
Tagaya et al., Hachiōji, Japan. In Dev Cell, Mar 2015
Syn17 also regulates ER Ca(2+) homeostasis and interferes with Rab32-mediated regulation of mitochondrial dynamics.
Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I.
Clarke et al., Vancouver, Canada. In Mol Genet Metab, Feb 2015
Genome-wide expression studies in embryonic day 13.5 limb cartilage and 5 week growth plate cartilage followed by specific gene candidate qPCR studies in the 5week growth plate identified fourteen significantly deregulated mRNAs (Adamts12, Aspn, Chad, Col2a1, Col9a1, Hapln4, Lum, Matn1, Mmp3, Ogn, Omd, P4ha2, Prelp, and Rab32).
Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.
Fukuda et al., Sendai, Japan. In Biol Open, 2014
Varp (VPS9-ankyrin repeat protein) was originally identified as an activator of small GTPase Rab21 through its VPS9 domain, but it has subsequently been shown to function as a Rab32/38 effector through its first ANKR1 domain.
Improvement in Mouse iPSC Induction by Rab32 Reveals the Importance of Lipid Metabolism during Reprogramming.
Han et al., Beijing, China. In Sci Rep, 2014
By testing the efficiency of iPSC generation using Oct4, Sox2, Klf4 (termed OSK) plus one additional gene, we found that Rab32 improved reprogramming efficiency.
Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins.
Simmen et al., Edmonton, Canada. In Cell Logist, 2014
The GTPase Rab32 regulates this function of the MAM via determining the localization of the Ca(2+) regulatory transmembrane protein calnexin to the MAM.
Host restriction in Salmonella: insights from Rab GTPases.
Spanò, Aberdeen, United Kingdom. In Cell Microbiol, 2014
Recently, an antimicrobial traffic pathway dependent on the Rab GTPase Rab32 and its exchange factor BLOC-3 was found to be critical to kill S. Typhi in macrophages from non-susceptible hosts, suggesting that this pathway delivers an antimicrobial factor to the S. Typhi vacuole.
Regulation of autophagy by the Rab GTPase network.
Wu et al., Chongqing, China. In Cell Death Differ, 2014
Rab1, Rab5, Rab7, Rab9A, Rab11, Rab23, Rab32, and Rab33B participate in autophagosome formation, whereas Rab9 is required in non-canonical autophagy.
A novel anti-microbial function for a familiar Rab GTPase.
Galán et al., New Haven, United States. In Small Gtpases, 2013
We recently reported that a pathway dependent on the Rab GTPase Rab32 and its guanine-nucleotide exchange factor BLOC-3 restricts the growth and survival of S. Typhi in non-permissive macrophages.
Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.
Di Pietro et al., Fort Collins, United States. In Small Gtpases, 2013
Two small GTPases, Rab32 and Rab38, are key proteins in the biogenesis of melanosomes and were recently shown to redirect the ubiquitous machinery-BLOC-2, AP-1 and AP-3-to traffic specialized cargoes to melanosomes in melanocytes.
Rab proteins of the endoplasmic reticulum: functions and interactors.
Simmen et al., Edmonton, Canada. In Biochem Soc Trans, 2013
Rab32 or Rab24) could aid proteins of the atlastin and reticulon families in determining the extent and direction of ER tubulation.
A Rab32-dependent pathway contributes to Salmonella typhi host restriction.
Galán et al., New Haven, United States. In Science, 2012
This effector proteolytically targeted Rab32, which controls traffic to lysosome-related organelles in conjunction with components of the biogenesis of lysosome-related organelle complexes (BLOCs).
BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles.
Di Pietro et al., Fort Collins, United States. In J Biol Chem, 2012
that Rab38 and Rab32 are the specific factors that direct the ubiquitous machinery to mediate transport from early endosomes to maturing LROs.
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
Zhang et al., Jinan, China. In Nat Genet, 2011
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy
Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties.
Simmen et al., Edmonton, Canada. In J Biol Chem, 2010
Through a combination of its functions as a PKA-anchoring protein and a regulator of MAM properties, the activity and expression level of Rab32 determine the speed of apoptosis onset.
A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions.
Tanaka et al., Fukuoka, Japan. In Cell Mol Life Sci, 2009
Results suggest that Rab32 facilitates the formation of autophagic vacuoles whose membranes are derived from the ER and regulates the clearance of aggregated proteins by autophagy.
Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes.
Fukuda et al., Sendai, Japan. In Mol Biol Cell, 2009
Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes.
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