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RAB31, member RAS oncogene family

Rab31, Rab22B, monomeric GTP-binding protein, monomeric GTP-binding protein,
Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009] (from NCBI)
Top mentioned proteins: Rhodopsin, CAN, Rab5, RhoA, HAD
Papers on Rab31
Role for Rab10 in Methamphetamine-Induced Behavior.
Neve et al., Portland, United States. In Plos One, 2014
LC-MS analysis of the protein composition of raft fractions from rats treated once with methamphetamine or saline identified methamphetamine-induced changes in the relative abundance of 23 raft proteins, including the monomeric GTP-binding protein Rab10, whose abundance in rafts was decreased 2.1-fold by acute methamphetamine treatment.
New angle of view on the role of rho/rho kinase pathway in human diseases.
Wang et al., Chengdu, China. In Iran J Allergy Asthma Immunol, 2014
Rho-kinase is an effector molecule of RhoA, a monomeric GTP-binding protein, and causes Ca2+ sensitization through inactivation of myosin phosphatase.
Tissue-based microarray expression of genes predictive of metastasis in uveal melanoma and differentially expressed in metastatic uveal melanoma.
Elner et al., United States. In J Ophthalmic Vis Res, 2013
PURPOSE: To screen the microarray expression of CDH1, ECM1, EIF1B, FXR1, HTR2B, ID2, LMCD1, LTA4H, MTUS1, RAB31, ROBO1, and SATB1 genes which are predictive of primary uveal melanoma metastasis, and NFKB2, PTPN18, MTSS1, GADD45B, SNCG, HHIP, IL12B, CDK4, RPLP0, RPS17, RPS12 genes that are differentially expressed in metastatic uveal melanoma in normal whole human blood and tissues prone to metastatic involvement by uveal melanoma.
Novel signatures of cancer-associated fibroblasts.
Klein et al., Stockholm, Sweden. In Int J Cancer, 2013
Twelve new proteins differentially expressed in cancer-associated fibroblasts were identified (DLG1, BHLHE40, ROCK2, RAB31, AZI2, PKM2, ARHGAP31, ARHGAP26, ITCH, EGLN1, RNF19A and PLOD2), four of them can be connected to the Rho kinase signaling pathway.
DHT and IGF-1 in peripheral blood lymphocytes: new markers for the biological passport of athletes.
Buono et al., Napoli, Italy. In J Biol Regul Homeost Agents, 2013
We identified six (IDO1, CXCL13, CCL1, GZMB, VDR and IL2RA) and two (FN1 and RAB31) genes that were up-regulated in lymphocytes from sedentary subjects after 7 days of DHT and IGF-1 treatment, respectively.
Reverse engineering of modified genes by Bayesian network analysis defines molecular determinants critical to the development of glioblastoma.
Roy et al., Miami, United States. In Plos One, 2012
Genes found to be most influential to development of the highest grade of astrocytoma, Glioblastoma multiforme were: COL4A1, EGFR, BTF3, MPP2, RAB31, CDK4, CD99, ANXA2, TOP2A, and SERBP1.
Rab GTPases regulating receptor trafficking at the late endosome-lysosome membranes.
Tang et al., Singapore, Singapore. In Cell Biochem Funct, 2012
Amongst these, Rab7, Rab9 and the more recently studied Rab22B/31 have all been reported to regulate membrane trafficking processed at the late endosome-lysosome system.
Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis.
Akdis et al., Zürich, Switzerland. In J Allergy Clin Immunol, 2012
Three apoptosis-related genes (NOD2, DUSP1, and ADM) and 8 genes overexpressed in AD skin lesions (CCDC109B, CCL5, CCL8, IFI35, LYN, RAB31, IFITM1, and IFITM2) were induced by IFN-γ in primary keratinocytes.
Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells.
Magdolen et al., München, Germany. In Mol Cancer, 2011
Several Rab proteins, including rab31, have been shown to affect cancer progression and are related with prognosis in various types of cancer including breast cancer.
Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα.
Zamponi et al., Calgary, Canada. In Plos One, 2011
BACKGROUND: Rem2 is a small monomeric GTP-binding protein of the RGK family, whose known functions are modulation of calcium channel currents and alterations of cytoskeletal architecture.
mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer.
Magdolen et al., Dresden, Germany. In Biol Chem, 2011
Neither UPARwt, nor UPAR-del4/5 nor RAB31 mRNA expression levels were found to be prognostic markers in advanced ovarian cancer.
Rab22 controls NGF signaling and neurite outgrowth in PC12 cells.
Li et al., Oklahoma City, United States. In Mol Biol Cell, 2011
The data provide the first evidence for Rab22 (also known as Rab22b, Rab31) as a positive regulator of nerve growth factor (NGF) signal transduction and cell differentiation.
Role of RNA binding protein HuR in ductal carcinoma in situ of the breast.
Ristimäki et al., Helsinki, Finland. In J Pathol, 2011
In addition, we identified two novel target transcripts (CTGF and RAB31) that are regulated by HuR and that bind HuR protein in this cell line.
Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31.
Katada et al., Tokyo, Japan. In J Biol Chem, 2011
RIN3 specifically acts as a GEF for Rab31.
Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells.
Tang et al., Singapore, Singapore. In J Cell Physiol, 2009
Rab22B is exceptionally enriched in nestin and RC2-positive radial glia of the embryonic mouse brain. In the adult brain, Rab22B is rather specifically expressed in glial fibrillary acidic protein (GFAP)-positive mature astrocytes.
RhoA, a possible target for treatment of airway hyperresponsiveness in bronchial asthma.
Misawa et al., Japan. In J Pharmacol Sci, 2009
The latter Ca²+-independent pathway, termed Ca²+ sensitization, is mainly regulated by a monomeric GTP-binding protein, RhoA, and its downstream target Rho-kinase.
Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31.
Larocca et al., United States. In Exp Cell Res, 2009
Data demonstrate that Rab31 is required for transport of mannose 6-phosphate receptors from the trans-Golgi network to endosomes and for the Golgi/TGN organization.
Rab GTPases and their roles in brain neurons and glia.
Tang et al., Singapore, Singapore. In Brain Res Rev, 2008
Much less is known about the role of Rabs in astroglia/oligodendroglia-specific processes, although Rab family members that are glia-enriched (Rab22B, Rab40C) have been reported.
RhoA/Rho-kinase as a therapeutic target in asthma.
Kume, Nagoya, Japan. In Curr Med Chem, 2007
Rho-kinase is an effector molecule of RhoA, a monomeric GTP-binding protein, and causes Ca(2+) sensitization via inactivation of myosin phosphatase.
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