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RAB24, member RAS oncogene family

RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009] (from NCBI)
Top mentioned proteins: ACID, Rab5, Ubiquitin, CD14, V1a
Papers on Rab24
Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum.
Grewal et al., Drammen, Norway. In Sci Rep, Dec 2015
We identified 12 biomarkers consistently associated with either clinical groups "upstream" towards culture-positive TB on the TB disease spectrum (CD14, FCGR1A, FPR1, MMP9, RAB24, SEC14L1, and TIMP2) or "downstream" towards a decreased likelihood of TB disease (BLR1, CD3E, CD8A, IL7R, and TGFBR2), suggesting a correlation with MTB-related pathology and high relevance to a future POC test for pediatric TB.
RAB24 facilitates clearance of autophagic compartments during basal conditions.
Eskelinen et al., Helsinki, Finland. In Autophagy, Nov 2015
RAB24 belongs to a family of small GTPases and has been implicated to function in autophagy.
Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24.
Olby et al., Uppsala, Sweden. In Plos Genet, 2014
Targeted sequence capture and next generation sequencing of the region identified an A to C single nucleotide polymorphism (SNP) located at position 113 in exon 1 of an autophagy gene, RAB24, that segregated with the phenotype.
Autophagic marker MAP1LC3B expression levels are associated with carotid atherosclerosis symptomatology.
Alloza et al., Leioa, Spain. In Plos One, 2013
Comparison of the effects of 40% oxygen and two atmospheric absolute air pressure conditions on stress-induced premature senescence of normal human diploid fibroblasts.
Woo et al., Seoul, South Korea. In Cell Stress Chaperones, 2008
Among 26 statistically reliable genes, the expression of apoptosis related genes such as ADAM22, Bax, BCL2L14, and UBD, as well as tumor suppressor-related genes like Axin2 and ATF, and also mitogen-activated protein kinase-related genes like mitogen-activated protein kinase kinase kinase 1, histamine receptor, and RAB24, were significantly changed in cells responsive to pressure-induced oxidative stress.
Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP.
Mao et al., Shanghai, China. In Int J Mol Med, 2006
As an atypical member of the Rab family, Rab24 has several attributes distinguishing this protein from the other members.
Induced expressions of Rab24 GTPase and LC3 in nerve-injured motor neurons.
Kiyama et al., Ōsaka, Japan. In Biochem Biophys Res Commun, 2006
Expression of Rab24 mRNA was also induced in differentiated PC12 cells following proteasome inhibitor
PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein.
Wright et al., Leeds, United Kingdom. In Biochem J, 2004
In the present study we identify a novel mitochondrial protein, PRELI (protein of relevant evolutionary and lymphoid interest), that is encoded within the evolutionarily conserved MAD3/PRELI/RAB24 gene cluster located at chromosome 5q34-q35.
Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells.
Maltese et al., Toledo, United States. In Biochem Biophys Res Commun, 2004
This is the first report of tyrosine phosphorylation in any member of the Ras superfamily and it raises the possibility that this type of modification could influence Rab24 targeting and interactions with effector protein complexes.
Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues.
Zhao et al., Shanghai, China. In Gene Expr, 2001
In the present study, we have cloned nine novel genes encoding human small GTPases: RAB1B, RAB4B, RAB10, RAB22A, RAB24, RAB25 ARL5, SARA1, and SARA2, among which the former six belong to the RAB family and the latter three belong to the ARF/SAR1 family.
Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture.
Drossard et al., Aachen, Germany. In J Immunol Methods, 1999
However, in suspension culture, the full-size recombinant antibody, rAb24, was retained by the plant cell wall and was not present in the culture medium.
Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily.
Simons et al., Heidelberg, Germany. In J Cell Sci, 1993
These PCR fragments have not been used with cDNA library screening and PCR-based techniques to clone the cDNAs encoding three of these proteins, rab12, rab22, and rab24.
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