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RAB2A, member RAS oncogene family

The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: Rab5, YPT1, ACID, CAN, fibrillin-1
Papers on Rab2
CHARGE syndrome due to deletion of region upstream of CHD7 gene START codon.
Dallapiccola et al., Roma, Italy. In Bmc Med Genet, 2014
Using CGH array and NGS analysis we detected a microdeletion (184 kb) involving the promoter region and exon 1 of CHD7 gene and the flanking RAB2 gene.
Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans.
Sidjanin et al., Milwaukee, United States. In Am J Hum Genet, 2014
Functional analysis established the mouse TBC1D20 protein as a GTPase-activating protein (GAP) for RAB1 and RAB2, and bs as a TBC1D20 loss-of-function mutation.
An approach to quantify endomembrane dynamics in pollen utilizing bioactive chemicals.
Raikhel et al., Riverside, United States. In Mol Plant, 2013
To address this problem, we screened for small molecules that perturbed the localization of a marker for the Golgi Ras-like monomeric G-protein RAB2:GFP expressed in transgenic tobacco pollen.
Duplication 8q12: confirmation of a novel recognizable phenotype with duane retraction syndrome and developmental delay.
Geneviève et al., Montpellier, France. In Eur J Hum Genet, 2012
The minimal critical region is 1.2 Mb and encompasses four genes: CA8, RAB2, RLBP1L1 and CHD7.
Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2.
De Bolle et al., Namur, Belgium. In Cell Microbiol, 2011
The authors identified a specific interaction between the human small GTPase Rab2 and a Brucella spp. protein named RicA.
Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
Webster et al., Rockville, United States. In Mol Psychiatry, 2011
The results of this study provided that RAB2A and SLC38A1, were associated with the density of calbindin-positive neurons and the number of perineuronal oligodendrocytes in psychiatric disorders.
Rab GTPases act in sequential steps to regulate phagolysosome formation.
Wang et al., Beijing, China. In Small Gtpases, 2010
Three Rabs, RAB-14, UNC-108/RAB2 and RAB-7, act cooperatively to control phagolysosome formation.
Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation.
Wang et al., Beijing, China. In Proc Natl Acad Sci U S A, 2010
RAB-14 and UNC-108/RAB2 are recruited to phagosomes at a similar stage and function redundantly to regulate phagosome maturation.
Biogenesis of sperm perinuclear theca and its role in sperm functional competence and fertilization.
Sutovsky et al., Kingston, Canada. In J Reprod Immunol, 2009
In this review data collected on resident perinuclear theca proteins, SubH2Bv, RAB2, PAWP and the four core somatic histones, is used to substantiate these hypotheses.
Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion.
Bergsten et al., Uppsala, Sweden. In Proteome Sci, 2008
Identified proteins included alpha glucosidase, calmodulin, gars, glucose-6-phosphate dehydrogenase, heterogenous nuclear ribonucleoprotein A3, lon peptidase, nicotineamide adenine dinucleotide hydrogen (NADH) dehydrogenase, phosphoglycerate kinase, proteasome p45, rab2, pyruvate kinase and t-complex protein.
RAB2A: a major subacrosomal protein of bovine spermatozoa implicated in acrosomal biogenesis.
Oko et al., Kingston, Canada. In Biol Reprod, 2008
An unprecedented direction of RAB2A-mediated vesicular transport in spermatids during acrosomal biogenesis, from the trans-side of the Golgi apparatus to the nuclear envelope.
ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.
Solimena et al., Dresden, Germany. In Eur J Cell Biol, 2008
ICA69 as a novel Rab2 effector and its role in regulating the early transport of insulin secretory granule proteins
Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases.
Wu et al., New Orleans, United States. In Cell Signal, 2007
These data demonstrate that Rab2 and Rab6 differentially influence anterograde transport and signaling of GPCRs.
Correcting false gene expression measurements from degraded RNA using RTQ-PCR.
Abend et al., München, Germany. In Diagn Mol Pathol, 2007
Gene expression (eg, Bcl-2, GAPDH, PGK, PSME3, RAB2, BAX) was measured using RTQ-PCR.
Measurement of volumetric flow.
Fowlkes et al., Ann Arbor, United States. In J Ultrasound Med, 2006
METHODS: A GE/Kretz Voluson 730 system (GE Healthcare, Milwaukee, WI) and RAB2-5 probe were used to acquire 3D Doppler measurements in a custom flow phantom.
Small GTP-binding proteins in parietal cells: candidate modulators of parietal cell membrane dynamics.
Modlin et al., New Haven, United States. In Yale J Biol Med, 1992
One 23 kDa smGTPBP has been localized to tubulovesicles and identified immunochemically as rab2.
Hypervariable C-terminal domain of rab proteins acts as a targeting signal.
Zerial et al., Heidelberg, Germany. In Nature, 1991
To define the region mediating their specific localization, we transiently expressed rab2, rab5 and rab7 hybrid proteins in BHK cells, and determined their intracellular localization by immunofluorescence confocal microscopy and subcellular fractionation.
rab5 controls early endosome fusion in vitro.
Gruenberg et al., Heidelberg, Germany. In Cell, 1991
The small GTP-binding protein rab5 was previously localized on early endosomes and on the cytoplasmic face of the plasma membrane.
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments.
Zerial et al., Heidelberg, Germany. In Cell, 1990
One, the MDCK homolog of rab2, is associated with a structure having the characteristics of an intermediate compartment between the endoplasmic reticulum and the Golgi apparatus.
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