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Crystallin, zeta

quinone oxidoreductase, zeta-crystallin
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: oxidoreductase, Nrf2, V1a, CAN, ACID
Papers on quinone oxidoreductase
Involvement of Nuclear Related Factor 2 Signaling Pathway in the Brain of Obese Rats and Obesity-Resistant Rats Induced by High-Fat Diet.
Xiao et al., Beijing, China. In J Med Food, Feb 2016
In addition, the protein expression of Nrf2 and its downstream factors such as heme oxygenase 1, manganese superoxide dismutase, and NAD(P)H quinone oxidoreductase 1 (NQO1) in the brain tissue were measured by Western blotting.
Natural small molecules as stabilizers and activators of cancer-associated NQO1 polymorphisms.
In Curr Drug Targets, Feb 2016
UNASSIGNED: NAD(P)H:quinone oxidoreductase 1 (NQO1) is an antioxidant and detoxifying enzyme involved in the two-electron reduction of a wide variety of quinones.
Penicillin G increases the synthesis of a suicidal marker (CidC) and virulence (HlgBC) proteins in Staphylococcus aureus biofilm cells.
Varmanen et al., Helsinki, Finland. In Int J Med Microbiol, Jan 2016
Increased abundance was also found for the TCA cycle associated malate-quinone oxidoreductase (Mqo), the ClpC ATPase, the HlgBC toxin and phage-associated proteins, which suggests that surviving cells have induced these activities as a last effort to overcome lethal doses of PenG.
Protopanaxatriol Ginsenoside Rh1 Upregulates Phase II Antioxidant Enzyme Gene Expression in Rat Primary Astrocytes: Involvement of MAP Kinases and Nrf2/ARE Signaling.
Kim et al., Seoul, South Korea. In Biomol Ther (seoul), Jan 2016
Rh1 increased the expression of phase II antioxidant enzymes, such as heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1, superoxide dismutase-2, and catalase, that are under the control of Nrf2/ARE signaling pathways.
Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity.
Jung et al., Taejŏn, South Korea. In Toxicol Lett, Jan 2016
Herein, we explored whether deletion of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoprotective gene, affected MRN complex expression in the kidney after cisplatin-induced acute kidney injury (AKI).
Activation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1.
Chan et al., Kao-hsiung, Taiwan. In Pharmacol Ther, Dec 2015
Furthermore, activators of DJ-1 are available in the form of mortalin, phenylbutyrate and NAD(P)H: quinone oxidoreductase 1.
Implications of NQO1 in cancer therapy.
Park et al., Inch'ŏn, South Korea. In Bmb Rep, Nov 2015
NAD(P)H: quinone oxidoreductase (NQO1), an obligatory two-electron reductase, is a ubiquitous cytosolic enzyme that catalyzes the reduction of quinone substrates.
Deoxynyboquinones as NQO1-Activated Cancer Therapeutics.
Hergenrother et al., Urbana, United States. In Acc Chem Res, Nov 2015
A potential cancer-specific target is the enzyme NAD(P)H quinone oxidoreductase 1 (NQO1).
Omeprazole does not Potentiate Acute Oxygen Toxicity in Fetal Human Pulmonary Microvascular Endothelial Cells Exposed to Hyperoxia.
Shivanna et al., Houston, United States. In Pharm Anal Acta, Oct 2015
Furthermore, OM at a concentration of 100 μM (OM 100) increased NADP(H) quinone oxidoreductase 1 (NQO1) expression.
Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.
Sutherland et al., Dundee, United Kingdom. In Biochem Soc Trans, Sep 2015
We present data showing that in the absence of Keap1, the electrophile tert-butyl hydroquinone (tBHQ) can stimulate Nrf2 activity and induce the Nrf2-target gene NAD(P)H: quinone oxidoreductase-1 (NQO1), whilst simultaneously causing inhibitory phosphorylation of GSK-3β at Ser(9).
Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase.
Fritz et al., Stuttgart, Germany. In Nature, 2015
The sodium-translocating NADH:quinone oxidoreductase (Na(+)-NQR), a membrane protein complex widespread among pathogenic bacteria, consists of six subunits, NqrA, B, C, D, E and F. To our knowledge, no structural information on the Na(+)-NQR complex has been available until now.
Nanotechnology-enabled delivery of NQO1 bioactivatable drugs.
Gao et al., Dallas, United States. In J Drug Target, 2014
β-Lapachone (β-lap) is a novel anticancer agent whose mechanism of action is highly dependent on NAD(P)H: quinone oxidoreductase 1 (NQO1), a phase II detoxifying enzyme overexpressed in solid tumors from a variety of cancer types.
Novel alkenal/one reductase activity of yeast NADPH:quinone reductase Zta1p. Prospect of the functional role for the ζ-crystallin family.
Fernández et al., Barcelona, Spain. In Chem Biol Interact, 2011
role of Zta1p in the yeast adaptation to some stress types and the general functional significance of zeta-crystallins
Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.
Parés et al., Barcelona, Spain. In Cell Mol Life Sci, 2011
novel enzymatic activity for human zeta-crystallin, the double- bond a,b-hydrogenation of 2-alkenals and 3-alkenones, was identified.
zeta-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia.
Capaccioli et al., Florence, Italy. In Faseb J, 2010
zeta-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia.
Zeta-crystallin mediates the acid pH-induced increase of BSC1 cotransporter mRNA stability.
Karim et al., Paris, France. In Kidney Int, 2009
induction of zeta-crystallin by an acid pH plays an important role in preventing BSC1 mRNA decay
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
Nevanlinna et al., Helsinki, Finland. In Nat Genet, 2008
NQO1 guards against oxidative stress and carcinogenesis and stabilizes p53.
Energy converting NADH:quinone oxidoreductase (complex I).
Brandt, Frankfurt am Main, Germany. In Annu Rev Biochem, 2005
NADH:quinone oxidoreductase (complex I) pumps protons across the inner membrane of mitochondria or the plasma membrane of many bacteria.
Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer.
Erlichman et al., Rochester, United States. In J Clin Oncol, 2005
We also characterized the pharmacokinetics of 17-AAG, its effect on chaperone and client proteins, and whether cytochrome P450 (CYP) 3A5 and NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphisms affected 17-AAG disposition or toxicity.
Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.
Montano et al., Cleveland, United States. In Mol Endocrinol, 2003
up-regulation of quinone reductase can protect breast cells against oxidative DNA damage
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