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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Quaking, QKI
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, MBP, ACID
Papers on Quaking
Heidenhain variant in two patients with inherited V210I Creutzfeldt-Jakob disease.
Pisani et al., Roma, Italy. In Int J Neurosci, Apr 2016
METHODS: Patients underwent neurological examination, electroencephalogram (EEG), brain magnetic resonance images (MRI) and cerebrospinal fluid (CSF) analysis including the Real Time Quaking Induced Conversion (RT-QuIC) test.
Alternative Splicing in the Human PMP22 Gene: Implications in CMT1A Neuropathy.
Nobbio et al., Genova, Italy. In Hum Mutat, Jan 2016
In addition, we showed a remarkable derangement in rat QKI expression, which is a critical regulator of splicing during myelination.
Oligodendroglial defects during quakingviable cerebellar development.
Zheng et al., Atlanta, United States. In Dev Neurobiol, Jan 2016
UNASSIGNED: The selective RNA-binding protein Quaking I (QKI) has previously been implicated in RNA localization and stabilization, alternative splicing, cell proliferation and differentiation.
Characterization and Expression of the Zebrafish qki Paralogs.
Emilsson et al., Uppsala, Sweden. In Plos One, Dec 2015
Quaking (QKI) is an RNA-binding protein involved in post-transcriptional mRNA processing.
Linkage and whole genome sequencing identify a locus on 6q25-26 for formal thought disorder and implicate MEF2A regulation.
Werge et al., Roskilde, Denmark. In Schizophr Res, Dec 2015
The MEF2A binding site is located between two genes previously reported to associate with schizophrenia, QKI (HGNC:21100) and PDE10A (HGNC:8772).
Quaking and miR-155 interactions in inflammation and leukemogenesis.
Croce et al., Columbus, United States. In Oncotarget, Oct 2015
Quaking (QKI) is a tumor-suppressor gene encoding a conserved RNA-binding protein, whose expression is downregulated in several solid tumors.
The RNA binding protein quaking regulates formation of circRNAs.
Goodall et al., Adelaide, Australia. In Cell, Apr 2015
We show that hundreds of circRNAs are regulated during human epithelial-mesenchymal transition (EMT) and find that the production of over one-third of abundant circRNAs is dynamically regulated by the alternative splicing factor, Quaking (QKI), which itself is regulated during EMT.
RNA-binding proteins in neurological diseases.
Wu et al., In Sci China Life Sci, 2014
Here, we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfox1/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.
Depinho et al., Boston, United States. In Genes Dev, 2012
establish that p53 directly regulates Quaking (QKI) gene expression, and QKI protein associates with and leads to the stabilization of miR-20a
Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis.
Lu et al., Xi'an, China. In Biochem Biophys Res Commun, 2012
Multivariate analysis showed QKI expression was an independent prognostic factor for patient survival.
The RNA-binding protein QKI5 is a direct target of C/EBPα and delays macrophage differentiation.
Lu et al., Xi'an, China. In Mol Biol Cell, 2012
The RNA-binding protein QKI5 is a direct target of C/EBPalpha and delays macrophage differentiation.
MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release.
Sluijter et al., Utrecht, Netherlands. In Cardiovasc Res, 2012
MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release.
RNA binding protein QKI inhibits the ischemia/reperfusion-induced apoptosis in neonatal cardiomyocytes.
Lu et al., Xi'an, China. In Cell Physiol Biochem, 2010
The overexpression of either QKI5 or QKI6 suppressed IR-induced apoptosis substantially.
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
Tuschl et al., New York City, United States. In Cell, 2010
We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C.
Reaching for the stars: Linking RNA binding proteins to diseases.
Richard, Montréal, Canada. In Adv Exp Med Biol, 2009
The role of Sam68, a closely related family member quaking (QKI), the KH domain and their links with human disease will be discussed in the present chapter.
Drosophila star proteins: what can be learned from flies?
Volk, Israel. In Adv Exp Med Biol, 2009
This chapter focuses on two Drosophila STAR proteins: held out wing (HOW), the ortholog of mammalian quaking (QKI) and Kep1, one of the four orthologs of mammalian Sam 68.
The star family member QKI and cell signaling.
Bankston et al., Atlanta, United States. In Adv Exp Med Biol, 2009
This chapter provides a short review of the STAR member QKI, focusing on the essential role of QKI in development of the central nervous system, possible mechanisms by which QKI may link cell signaling to the cellular behavior of its mRNA targets and how QKI dysregulation may contribute to human diseases.
STAR trek: An introduction to STAR family proteins and review of quaking (QKI).
Wu et al., Austin, United States. In Adv Exp Med Biol, 2009
We have concentrated on QKI as an example of this pleiotropic activity and also presented some new data on the role of its conserved 3'UTRs gleaned from bioinformatics analysis of theoretical miRNA binding sites.
Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis.
Gartner et al., Martinsried, Germany. In Cell, 2005
In a genetic screen for negative regulators of CEP-1, we identified a mutation in GLD-1, a translational repressor implicated in multiple C. elegans germ cell fate decisions and related to mammalian Quaking proteins.
APPEL et al., In Science, 1964
Quaking is a new autosomal recessive mutant mouse with marked tremor of the hindquarters.
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