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Retina and anterior neural fold homeobox 2

This gene encodes a homeodomain-containing protein that plays a role in eye development. Mutation of this gene causes age-related macular degeneration type 6, an eye disorder resulting in accumulations of protein and lipid beneath the retinal pigment epithelium and within the Bruch's membrane. Defects in this gene can also cause cone-rod dystrophy type 11, a disease characterized by the initial degeneration of cone photoreceptor cells and resulting in loss of color vision and visual acuity, followed by the degeneration of rod photoreceptor cells, which progresses to night blindness and the loss of peripheral vision. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: TRbeta, Rhodopsin, Lck, RET, CRX
Papers on Qrx
Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.
Zack et al., Baltimore, United States. In Adv Exp Med Biol, Dec 2015
Primary postnatal day four retinal cells from the photoreceptor (PR) labeled QRX-EGFP reporter mice were isolated, seeded, treated with a set of 234 profiled kinase inhibitors and then cultured for 1 week.
Sobetirome: a case history of bench-to-clinic drug discovery and development.
Scanlan, Portland, United States. In Heart Fail Rev, 2010
Sobetirome, also known as GC-1 and QRX-431, is a member of a class of compounds known as selective thyromimetics (Scanlan et al., Curr Opin Drug Discov Dev 4:614-622).
The role of Xenopus Rx-L in photoreceptor cell determination.
Hollemann et al., Halle, Germany. In Dev Biol, 2009
A phylogenic analysis of all reported Rx-type genes revealed that they could be grouped into three categories, including an "invertebrate Rx" group, a "classical vertebrate Rx" group, and a "vertebrate Qrx/Rx-L" group.
QRX, a novel homeobox gene, modulates photoreceptor gene expression.
Zack et al., Baltimore, United States. In Hum Mol Genet, 2004
A novel paired-like homeobox gene, designated as Qrx, was identified by a yeast one-hybrid screen using the bovine Rhodopsin promoter Ret-1 DNA regulatory element as bait.
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