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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Pygopus 2

pygopus 2, Pygo2, mpygo2
Top mentioned proteins: TCF, Histone, PYGO1, CAN, Wnt1
Papers on pygopus 2
Role of Msi1 and PYGO2 in esophageal squamous cell carcinoma depth of invasion.
Abbaszadegan et al., Mashhad, Iran. In J Cell Commun Signal, Jan 2016
PYGO2 is the main transcription factor of wnt pathway, while Msi1 is one of the wnt inhibitors.
Increased Pygo2 expression in liver of patients with hepatitis B virus-related fibrosis.
Zhu et al., Hefei, China. In Liver Int, Dec 2015
BACKGROUND & AIMS: It has been reported that Wnt/β-catenin signalling pathway played a key role in liver fibrosis and that Pygo2 was an important mediator in β-catenin induced pathway.
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives.
Lam et al., Gold Coast, Australia. In Crit Rev Oncol Hematol, Oct 2015
In oesophageal squamous cell carcinoma (ESCC), there are several markers such as CD44, ALDH, Pygo2, MAML1, Twist1, Musashi1, Side population (SP), CD271 and CD90 that have been proposed to identify the cancer stem cells in individual cancer masses.
Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.
Dai et al., Beijing, China. In J Biol Chem, Sep 2015
Pygopus 2 (Pygo2/PYGO2) is an evolutionarily conserved coactivator and chromatin effector in the Wnt/β-catenin signaling pathway that regulates cell growth and differentiation in various normal and malignant tissues.
Abnormal nuclear expression of Pygopus-2 in human primary hepatocellular carcinoma correlates with a poor prognosis.
Wang et al., China. In Histopathology, Aug 2015
AIMS: Pygopus-2 (Pygo2) is a critical element of the canonical Wnt/β-catenin transcriptional complex.
Pygo2 siRNA Inhibit the Growth and Increase Apoptosis of U251 Cell by Suppressing Histone H3K4 Trimethylation.
Wang et al., Fuzhou, China. In J Mol Neurosci, Aug 2015
Our previous study has demonstrated that Pygo2 is highly expressed in and promotes the growth of glioma cells.
Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation.
Wang et al., Guangzhou, China. In Oncotarget, May 2015
Furthermore, miR-432 directly targeted and suppressed multiple regulators of the Wnt/β-catenin signaling cascade, including LRP6, TRIM29 and Pygo2, which subsequently deactivated Wnt/β-catenin signaling pathway.
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia.
Carrell et al., Baoding, China. In Genet Mol Res, 2014
The Pygo2 gene is expressed in the elongating spermatid during chromatin remodeling; thus impairment in PYGO2 function might lead to spermatogenic arrest, sperm count reduction, and subsequent infertility.
Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.
Dai et al., Irvine, United States. In Proc Natl Acad Sci U S A, 2014
Here, we show that chromatin effector Pygopus homolog 2 (Pygo2) produced by the epithelial cells facilitates depilation-induced hair regeneration, as well as β-catenin-induced activation of hair follicle stem/early progenitor cells and trichofolliculoma-like skin hyperplasia.
Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development.
Sieber-Blum et al., Newcastle upon Tyne, United Kingdom. In Stem Cell Rev, 2014
To attenuate, but not silence, canonical Wnt signalling specifically in neural crest cells, we analyzed Wnt1-cre(+/-)::Pygo2(-/-) mice in which the β-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells.
Overexpression of Pygopus-2 is required for canonical Wnt activation in human lung cancer.
Wang et al., Tianjin, China. In Oncol Lett, 2014
The present study showed that Pygo2 is overexpressed in human lung cancer tissue samples and cell lines.
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs.
Rosenfeld et al., San Diego, United States. In Nature, 2013
Unexpectedly, recognition of specific protein marks by PCGEM1-recruited pygopus 2 PHD domain enhances selective looping of androgen-receptor-bound enhancers to target gene promoters in these cells.
Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells.
Dai et al., Irvine, United States. In Cell Stem Cell, 2013
Pygopus 2 (Pygo2) is a histone methylation reader and a context-dependent Wnt/β-catenin coactivator.
Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer.
Wang et al., Shenyang, China. In Bmc Cancer, 2012
BACKGROUND: Pygopus 2 (Pygo2) is a Pygo family member and an important component of the Wnt signaling transcriptional complex.
Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells.
Dai et al., Irvine, United States. In Cell Cycle, 2012
Pygo2 directly occupies the promoters of multiple histone genes and enhances the acetylation of lysine 56 in histone H3.
The role of Pygopus 2 in rat glioma cell growth.
Wang et al., Xiamen, China. In Med Oncol, 2011
Pygo2 is highly expressed in and promotes the growth of glioma cells
Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.
Li et al., Xiamen, China. In Mol Cell Biol, 2010
Data show that Pygo2 associates with MLL2 histone methyltransferase and STAGA histone acetyltransferase to facilitate their interaction with beta-catenin and Wnt1-induced, TCF/LEF-dependent transactivation in breast cancer cells.
Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth.
Wang et al., Xiamen, China. In J Neurooncol, 2010
The study demonstrated that Pygo2 was highly expressed in glioma tissue and required for growth of glioblastoma cells.
Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.
Bienz et al., Cambridge, United Kingdom. In J Mol Biol, 2010
Pygo2 PHD is the only known PHD finger that is capable of interacting simultaneously with two functional ligands, B9L and BCL9
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades.
Katoh et al., Tokyo, Japan. In Cancer Biol Ther, 2006
Nuclear beta-catenin is complexed with TCF/LEF, Legless (BCL9 or BCL9L) and PYGO (PYGO1 or PYGO2) to activate transcription of CCND1, MYC, FGF18 and FGF20 genes for the cell-fate determination.
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