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Purine rich element binding protein A

Puralpha, PURA
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, Actin, V1a
Papers on Puralpha
Circadian Rhythms in Rho1 Activity Regulate Neuronal Plasticity and Network Hierarchy.
Blau et al., East New York, United States. In Cell, Sep 2015
Rhythms in Rho1 activity are controlled by clock-regulated transcription of Puratrophin-1-like (Pura), a Rho1 GEF.
Strategy for enhancing adenosine production under the guidance of transcriptional and metabolite pool analysis.
Chen et al., Tianjin, China. In Biotechnol Lett, Jul 2015
RESULTS: PurR-regulated genes (pur operon and purA) and prs were down-regulated and 5-phosphoribosyl 1-pyrophosphate (PRPP) decreased considerably after 24 h when adenosine significantly accumulated.
Altered placental DNA methylation patterns associated with maternal smoking: current perspectives.
Maccani et al., Penn Hills, United States. In Adv Genomics Genet, Jun 2015
Epigenome-wide association studies have identified a number of differentially methylated placental genes that are associated with maternal smoking during pregnancy, including RUNX3, PURA, GTF2H2, GCA, GPR135, and HKR1.
Generation and evaluation of virulence attenuated mutants of Edwardsiella tarda as vaccine candidates to combat edwardsiellosis in flounder (Paralichthys olivaceus).
Huang et al., Qingdao, China. In Fish Shellfish Immunol, Mar 2015
In this study, we introduced deletions of esrB, esaC, evpH, rpoS, and purA into the E. tarda LSE40ΔaroA strain, thereby generating five double-gene mutants (ΔaroAΔesrB, ΔaroAΔesaC, ΔaroAΔrpoS, ΔaroAΔevpH, and ΔaroAΔpurA) and two triple-gene mutants (ΔaroAΔesrBΔevpH and ΔaroAΔesaCΔevpH).
Long-term follow-up of a patient with 5q31.3 microdeletion syndrome and the smallest de novo 5q31.2q31.3 deletion involving PURA.
Zucca et al., Médéa, Algeria. In Mol Cytogenet, 2014
BACKGROUND: Purine-rich element binding protein A (PURA, MIM 600473), is considered the crucial phenocritical gene for an emerging 5q31.3 microdeletion syndrome.
Whole exome sequencing in family trios reveals de novo mutations in PURA as a cause of severe neurodevelopmental delay and learning disability.
Baralle et al., Melbourne, Australia. In J Med Genet, 2014
RESULTS: Protein-altering de novo mutations in PURA were identified in four subjects.
Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome.
Xia et al., Houston, United States. In Am J Hum Genet, 2014
We describe 11 individuals with clinical features of 5q31.3 microdeletion syndrome and de novo mutations in PURA, encoding transcriptional activator protein Pur-α, within the critical region.
Longitudinal prevalence, faecal shedding and molecular characterisation of Campylobacter spp. and Salmonella enterica in sheep.
Ryan et al., Australia. In Vet J, 2014
purine biosynthesis gene (PurA) and the S. enterica outer membrane protein (ompF).
Ultra deep sequencing of Listeria monocytogenes sRNA transcriptome revealed new antisense RNAs.
Hain et al., Vienna, Austria. In Plos One, 2013
Interestingly among the newly identified sRNA candidates are antisense RNAs (asRNAs) associated to the housekeeping genes purA, fumC and pgi and potentially their regulation, emphasizing the significance of sRNAs for metabolic adaptation in L. monocytogenes.
Lack of Pur-alpha alters postnatal brain development and causes megalencephaly.
Herms et al., München, Germany. In Hum Mol Genet, 2012
This study underlines the importance of Puralpha in the proliferation of neuronal precursor cells during postnatal brain development and suggest a role for Puralpha in the regulation of the expression and cellular distribution of dendritic and axonal proteins.
Role of Purα in the cellular response to ultraviolet-C radiation.
Darbinyan et al., Philadelphia, United States. In Cell Cycle, 2010
Data suggest that Puralpha has a role in nucleotide excision repair and the repair of UVC-induced DNA damage.
Regulation of gonadotropin-releasing hormone-1 gene transcription by members of the purine-rich element-binding protein family.
Fernald et al., Stanford, United States. In Am J Physiol Endocrinol Metab, 2010
Overexpression of Purbeta, but not Puralpha, significantly downregulated GnRH1 mRNA Levels in transiently transfected GT1-7 cells, suggesting that Purbeta acts as a repressor of GnRH1 gene transcription.
Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals.
Johnson et al., Norfolk, United States. In Bmc Mol Biol, 2009
The study identifies three functionally distinct PURA promoters and show that these are utilized differentially in human cell types and that they respond differently to cytomegalovirus infection.
A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha).
Hatzoglou et al., Cleveland, United States. In J Biol Chem, 2009
analysis of how a bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha)
Multiple roles for Puralpha in cellular and viral regulation.
Khalili et al., Philadelphia, United States. In Cell Cycle, 2009
The creation of transgenic mice with inactivation of the PURA gene that encodes Puralpha has revealed that Puralpha is critical for postnatal brain development and has unraveled an essential role of Puralpha in the transport of specific mRNAs to the dendrites and the establishment of the postsynaptic compartment in the developing neurons.
The Pur protein family: clues to function from recent studies on cancer and AIDS.
Johnson, New York City, United States. In Anticancer Res, 2003
Several investigations have now implicated Pur alpha in pathways of inhibition of oncogenic transformation.
Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway.
Amini et al., Philadelphia, United States. In J Neurovirol, 2002
In parallel, Tat can bind to the cellular protein, Puralpha, which associates with cdk5.
[Gene expression by addictive drugs and drug dependence].
Miki, Suita, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, 2001
Pur alpha is abundant in the brain and binds to a single stranded DNA with (GGN)n sequence.
Puralpha: a multifunctional single-stranded DNA- and RNA-binding protein.
Khalili et al., Philadelphia, United States. In Nucleic Acids Res, 2000
Puralpha is a ubiquitous, sequence-specific DNA- and RNA-binding protein which is highly conserved in eukaryotic cells.
A sporulation-induced sigma-like regulatory protein from B. subtilis.
Losick et al., In Cell, 1981
We have demonstrated specific RNA synthesis by sigma 29-RNA polymerase using as a DNA template a cloned cluster of vegetative and sporulation genes from the purA-cysA region of the B. subtilis chromosome.
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