Generation and evaluation of virulence attenuated mutants of Edwardsiella tarda as vaccine candidates to combat edwardsiellosis in flounder (Paralichthys olivaceus).
Qingdao, China. In Fish Shellfish Immunol, Mar 2015
In this study, we introduced deletions of esrB, esaC, evpH, rpoS, and purA into the E. tarda LSE40ΔaroA strain, thereby generating five double-gene mutants (ΔaroAΔesrB, ΔaroAΔesaC, ΔaroAΔrpoS, ΔaroAΔevpH, and ΔaroAΔpurA) and two triple-gene mutants (ΔaroAΔesrBΔevpH and ΔaroAΔesaCΔevpH).
Multiple roles for Puralpha in cellular and viral regulation.
Philadelphia, United States. In Cell Cycle, 2009
The creation of transgenic mice with inactivation of the PURA gene that encodes Puralpha has revealed that Puralpha is critical for postnatal brain development and has unraveled an essential role of Puralpha in the transport of specific mRNAs to the dendrites and the establishment of the postsynaptic compartment in the developing neurons.