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Pumilio homolog 1

Pumilio, PUM1, Pumilio1
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, PUM2, V1a, iNOS, ACID
Papers on Pumilio
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.
Mendell et al., Dallas, United States. In Cell, Feb 2016
NORAD maintains genomic stability by sequestering PUMILIO proteins, which repress the stability and translation of mRNAs to which they bind.
Cytoplasmic polyadenylation in mammalian oocyte maturation.
Ross et al., Davis, United States. In Wiley Interdiscip Rev Rna, Jan 2016
The cytoplasmic polyadenylation (CP) element, Pumilio binding element, and hexanucleotide polyadenylation signal are among the best understood motifs involved in CP, and translational regulation of stored transcripts as their binding partners have been relatively well-characterized.
UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages.
Nussenzweig et al., Lucknow, India. In Plos Pathog, Jan 2016
Both uis1 and uis2 were highly transcribed in the salivary gland sporozoites but uis2 expression was inhibited by the Pumilio protein Puf2.
Target selection by natural and redesigned PUF proteins.
Wickens et al., Madison, United States. In Proc Natl Acad Sci U S A, Jan 2016
Pumilio/fem-3 mRNA binding factor (PUF) proteins bind RNA with sequence specificity and modularity, and have become exemplary scaffolds in the reengineering of new RNA specificities.
The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop.
Di Stefano et al., United States. In Mol Cell Biol, Jan 2016
Here, we report that reductions in the expression of the Pumilio (PUM) translational repressor complex enhanced phenotypes due to dLsd1 depletion in Drosophila.
Elucidation of novel budding yeast separase mutants.
Ushimaru et al., Shizuoka, Japan. In Biosci Biotechnol Biochem, Dec 2015
The Drosophila Pumilio homolog MPT5 was isolated as a high-dosage suppressor of esp1-ts cells.
Bespoke RNA recognition by Pumilios.
Edwards, Leeds, United Kingdom. In Biochem Soc Trans, Nov 2015
Pumilio is an RNA-binding protein originally identified in Drosophila, with a Puf domain made up of eight Puf repeats, three helix bundles arranged in a rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence.
Engineering reprogrammable RNA-binding proteins for study and manipulation of the transcriptome.
Zhao et al., Urbana, United States. In Mol Biosyst, Oct 2015
The elucidation of the RNA recognition code for Pumilio and fem-3 mRNA-binding factor (PUF) homology proteins allowed engineering of artificial RBPs for targeting endogenous mRNAs.
Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.
Zoghbi et al., Houston, United States. In Cell, Apr 2015
Seeking to understand how post-translational modification of ATAXIN1 levels influences disease, we discovered that the RNA-binding protein PUMILIO1 (PUM1) not only directly regulates ATAXIN1 but also plays an unexpectedly important role in neuronal function.
Regulation of membrane excitability: a convergence on voltage-gated sodium conductance.
Baines et al., Manchester, United Kingdom. In Mol Neurobiol, Feb 2015
The translational repressor Pumilio (Pum) can bind to Na v transcripts and repress the normal process of translation, thus regulating sodium current (INa) density in neurons.
PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane.
Lu et al., Stanford, United States. In Cell Metab, Feb 2015
Translationally repressed nRCC mRNAs are localized in a PINK1/Tom20-dependent manner to mitochondrial outer membrane, where they are derepressed and activated by PINK1/Parkin through displacement of translation repressors, including Pumilio and Glorund/hnRNP-F, a Parkin substrate, and enhanced binding of activators such as eIF4G.
SimiRa: A tool to identify coregulation between microRNAs and RNA-binding proteins.
Theis et al., München, Germany. In Rna Biol, 2014
We applied simiRa to the known functional cooperation between Pumilio family proteins and miR-221/222 in the regulation of tumor supressor gene p27 and show that the cooperation is reflected by similar enriched categories but not by target genes.
Role of PUF-8/PUF protein in stem cell control, sperm-oocyte decision and cell fate reprogramming.
Lee et al., Greenville, United States. In J Cell Physiol, 2014
Pumilio and FBF (PUF) proteins are conserved stem cell regulators that maintain germline stem cells (GSCs) in worms and flies.
Genetic exploration of the exit from self-renewal using haploid embryonic stem cells.
Smith et al., Kōbe, Japan. In Cell Stem Cell, 2014
These include the conserved small zinc finger protein Zfp706 and the RNA binding protein Pum1.
Pumilio facilitates miRNA regulation of the E2F3 oncogene.
Dyson et al., United States. In Genes Dev, 2012
Pumilio complexes repress dE2F1 levels
Drosophila Pumilio protein contains multiple autonomous repression domains that regulate mRNAs independently of Nanos and brain tumor.
Goldstrohm et al., Ann Arbor, United States. In Mol Cell Biol, 2012
Cofactors Brain Tumor and eIF4E Homologous Protein are not obligatory for Pumilio and Nanos activity.
Negative regulation of EGFR/MAPK pathway by Pumilio in Drosophila melanogaster.
Kim et al., Kwangju, South Korea. In Plos One, 2011
Evidence suggests that Pum functions as a negative regulator of EGFR signaling by directly targeting components of the pathway in Drosophila.
Neural-specific elongation of 3' UTRs during Drosophila development.
Haley et al., Berkeley, United States. In Proc Natl Acad Sci U S A, 2011
Data show that the extended 3' UTR sequences are selectively expressed in neural tissues and contain putative recognition motifs for the translational repressor, Pumilio, which also exhibits the 3' lengthening phenomenon.
Alternate modes of cognate RNA recognition by human PUMILIO proteins.
Hall et al., United States. In Structure, 2011
Three distinct modes of target RNA binding by PUM1 around the fifth mRNA base were observed.
Pumilio turns on microRNA function.
Gregory et al., In Nat Cell Biol, 2010
Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA.
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