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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein tyrosine phosphatase, mitochondrial 1

PTPMT1, Plip, PTEN-like phosphatase
Top mentioned proteins: PTEN, Insulin, Inactive, CAN, TNS
Papers on PTPMT1
PLIP: fully automated protein-ligand interaction profiler.
Schroeder et al., Dresden, Germany. In Nucleic Acids Res, Aug 2015
Here, we present the protein-ligand interaction profiler (PLIP), a novel web service for fully automated detection and visualization of relevant non-covalent protein-ligand contacts in 3D structures, freely available at
PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.
Peterson et al., United States. In Cell Rep, Mar 2015
We found that alexidine inhibits the PTEN-like mitochondrial phosphatase PTPMT1 and that other pharmacological and genetic means of inactivating PTPMT1 also decrease glucose levels in zebrafish.
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Schiöth et al., Uppsala, Sweden. In Genome Med, 2014
Out of 107 CpG sites, 38 are located in gene promoters, including genes strongly implicated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1, SH2B1, ATXN2L, and IL27).
The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1.
MacKeigan et al., Cambridge, United States. In Plos One, 2013
We identified the mitochondrial phosphatase, PTPMT1 (PTP localized to mitochondrion 1), as the most significant and unique interaction partner of MK-STYX.
Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica.
Zhang et al., San Diego, United States. In J Biol Chem, 2013
We recently identified the mitochondrial phosphatase, PTPMT1, as the enzyme that converts phosphatidylglycerolphosphate (PGP) to phosphatidylglycerol, a critical step in the de novo biosynthesis of cardiolipin.
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
Qu et al., Cleveland, United States. In Cell Stem Cell, 2013
Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in hematopoietic failure due to changes in the cell cycle and a block in the differentiation of HSCs.
A Dictyostelium secreted factor requires a PTEN-like phosphatase to slow proliferation and induce chemorepulsion.
Gomer et al., College Station, United States. In Plos One, 2012
In Dictyostelium discoideum, AprA and CfaD are secreted proteins that inhibit cell proliferation.
Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death.
MacKeigan et al., Grand Rapids, United States. In Plos One, 2012
Protein Tyrosine Phosphatase localized to the Mitochondrion 1 (PTPMT1) is a dual specificity phosphatase exclusively localized to the mitochondria, and has recently been shown to be a critical component in the cardiolipin biosynthetic pathway.
Chromatography approaches for early screening of the phospholipidosis-inducing potential of pharmaceuticals.
Reilly et al., Guangzhou, China. In J Pharm Biomed Anal, 2012
In this work, a high throughput physicochemical approach, which is based on measuring the retention factors of the test compound within several different separation systems, was developed for screening phospholipidosis-inducing potential (PLIP) of pharmaceuticals.
Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitors.
Jeong et al., Seoul, South Korea. In Bioorg Med Chem Lett, 2012
Dual-specificity protein tyrosine phosphatase localized to mitochondrion 1 (PTPMT1) has recently proved to be a promising therapeutic target for the treatment of type II diabetes.
A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells.
Qu et al., Cleveland, United States. In Mol Cell Biol, 2011
Targeted disruption of Ptpmt1 in mice results in postimplantation lethality.
Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
Dixon et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2011
PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion.
Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.
Dixon et al., San Diego, United States. In Cell Metab, 2011
mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis
PTPMT1: connecting cardiolipin biosynthesis to mitochondrial function.
Tremblay et al., Montréal, Canada. In Cell Metab, 2011
(2011) highlight a critical role for PTPMT1, a mitochondrial phosphatase, in cardiolipin biogenesis and possibly in cardiolipin deficiency diseases.
Pharmacological targeting of the mitochondrial phosphatase PTPMT1.
Casey et al., Durham, United States. In J Pharmacol Exp Ther, 2010
PTP localized to mitochondrion 1 (PTPMT1) is a recently discovered dual-specificity phosphatase that has been implicated in the regulation of insulin secretion.
Firing up mitochondrial activities with PTPMT1.
Tremblay et al., Ithaca, United States. In Mol Cell, 2005
Pagliarini et al (2005) recently identified a new mitochondrial specific protein tyrosine phosphatase, PTPMT1.
Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.
Dixon et al., San Diego, United States. In Mol Cell, 2005
PTPMT1 is targeted to the mitochondrion by an N-terminal signal sequence and is found anchored to the matrix face of the inner membrane. Knockdown of PTPMT1 in INS-1 832/13 cells enhances ATP production and insulin secretion.
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