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Protein tyrosine phosphatase, receptor type, E

PTPepsilon, PTPRE, RPTPepsilon
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Pts, Src, CAN, Protein-Tyrosine-Phosphatase, V1a
Papers on PTPepsilon
Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation.
Stapleton et al., Iowa City, United States. In Plos Pathog, Sep 2015
Cells expressing the HCV E2 coding RNA contained a short, virus-derived RNA predicted to be a Dicer substrate, which targeted a phosphatase involved in Src-kinase signaling (PTPRE).
Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population.
Tiwari et al., Bristol, United States. In Metabolism, Jun 2015
Bioinformatic analysis revealed DOCK1, PTPRE (10q26.13-2)
Increased frequency of de novo copy number variants in congenital heart disease by integrative analysis of single nucleotide polymorphism array and exome sequence data.
Chung et al., Philadelphia, United States. In Circ Res, 2014
encompassing CYFIP1, NIPA1, and NIPA2 and single de novo CNVs encompassing DUSP1, JUN, JUP, MED15, MED9, PTPRE SREBF1, TOP2A, and ZEB2, genes that interact with established CHD proteins NKX2-5 and GATA4.
The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma.
Jones et al., United Kingdom. In Acta Neuropathol Commun, 2013
We observed numerous gene disruptions by iCNA due to both deletions and amplifications, targeting known HGG-associated genes such as RB1 and NF1, putative tumour suppressors such as FAF1 and KIDINS220, and novel candidates such as PTPRE and KCND2.
Deregulation of protein phosphatase expression in acute myeloid leukemia.
Kazi et al., Barisāl, Bangladesh. In Med Oncol, 2013
Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes.
Multifaceted modulation of K+ channels by protein-tyrosine phosphatase ε tunes neuronal excitability.
Attali et al., Tel Aviv-Yafo, Israel. In J Biol Chem, 2012
Multifaceted modulation of K+ channels by protein-tyrosine phosphatase epsilon tunes neuronal excitability.
The nonreceptor-type tyrosine phosphatase PTPN13 is a tumor suppressor gene in non-small cell lung cancer.
Viglietto et al., Ariano Irpino, Italy. In Am J Pathol, 2012
Among the 38 PTPs in the human genome that show specificity for phosphotyrosine, we identified six PTPs by quantitative RT-PCR whose mRNA expression levels were significantly down-regulated in lung cancer-derived cell lines (ie, PTPRE, PTPRF, PTPRU, PTPRK, PTPRD, and PTPN13).
Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells.
Pulido et al., Valencia, Spain. In J Biol Chem, 2012
Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells.
Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma.
Dewan et al., New Haven, United States. In Hum Hered, 2010
Studies indicate that RAD50 and PTPRE of crude associations with asthma at a Bonferroni-corrected level of significance, while IL4R, CCL5 and TBXA2R of nominal significance.
Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells.
Miyazaki et al., Tsukuba, Japan. In Am J Physiol Cell Physiol, 2010
Data show that PTPepsilonM negatively regulates PDGFRbeta-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis, and PTPepsilonM may be involved in diabetes-accelerated atherosclerosis.
Integrative epigenomic and genomic analysis of malignant pheochromocytoma.
Wadelius et al., Uppsala, Sweden. In Exp Mol Med, 2010
Candidate tumor suppressor genes identified with decreased expression, a H3K27me3 mark and/or in regions of deletion were for instance TGIF1, DSC3, TNFRSF10B, RASSF2, HOXA9, PTPRE and CDH11.
Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination.
Pallen et al., Vancouver, Canada. In J Biol Chem, 2009
Findings demonstrate that PTPalpha is a critical regulator of Fyn activation and of specific Fyn signaling events during differentiation, and is essential for promoting OPC differentiation and central nervous system myelination.
Protein tyrosine phosphatases in osteoclast differentiation, adhesion, and bone resorption.
Elson et al., Israel. In Eur J Cell Biol, 2008
Here we summarize available information concerning the known and hypothesized roles of the best-researched PTPs in osteoclasts - PTPRO, PTP epsilon, SHP-1, and PTP-PEST.
Protein tyrosine phosphatase epsilon and Neu-induced mammary tumorigenesis.
Elson et al., Israel. In Cancer Metastasis Rev, 2008
The receptor-type tyrosine phosphatase Epsilon (RPTPepsilon) participates in supporting the transformed phenotype of mammary tumor cells induced in vivo by the Neu tyrosine kinase.
Protein tyrosine phosphatases in osteoclasts.
Elson et al., Israel. In Crit Rev Eukaryot Gene Expr, 2006
We review here the roles of the four tyrosine phosphatases that are known currently to be expressed in osteoclasts--PTPRO, PTP epsilon (PTPepsilon), SHP-1, and PTP-PEST.
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells.
Lapidot et al., Israel. In Nat Med, 2006
Specific stimulation of OCLs with RANKL recruited mainly immature progenitors to the circulation in a CXCR4- and MMP-9-dependent manner; however, RANKL did not induce mobilization in young female PTPepsilon-knockout mice with defective OCL bone adhesion and resorption.
Src kinase regulation by phosphorylation and dephosphorylation.
Roskoski, New Orleans, United States. In Biochem Biophys Res Commun, 2005
Candidate phosphotyrosine 527 phosphatases include cytoplasmic PTP1B, Shp1 and Shp2, and transmembrane enzymes include CD45, PTPalpha, PTPepsilon, and PTPlambda.
Regulation of cys-based protein tyrosine phosphatases via reactive oxygen and nitrogen species in mast cells and basophils.
Dráber et al., Praha, Czech Republic. In Curr Med Chem, 2004
Direct and indirect regulations of class I and II Cys-based protein tyrosine phosphatases (LMW-PTP, PTEN, PTP-PEST, SHP-2, PTP1B, PTPalpha, PTPepsilon, DEP-1, TC45, SHP-1, HePTP and LAR) are discussed.
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