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proteins. Page last changed on 19 Dec 2016.
Parathyroid hormone 2 receptor
PTH2 receptor, PTH2R, parathyroid hormone 2 receptor, PTHR2
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
Six1, Parathyroid Hormone, Parathyroid Hormone-Related Protein, PTH receptor, HAD
Papers on
PTH2 receptor
A genome-wide association study reveals a quantitative trait locus for days open on chromosome 2 in Japanese Black cattle.
New
Fukushima, Japan. In Anim Genet, Feb 2016
These SNPs were located on the telomeric side at a distance of 177 kb from the parathyroid hormone 2 receptor (PTH2R) gene.
Breakpoint mapping by whole genome sequencing identifies PTH2R gene disruption in a patient with midline craniosynostosis and a de novo balanced chromosomal rearrangement.
New
Wŏnju, South Korea. In J Med Genet, Oct 2015
An intronic break of the PTH2R gene was detected by whole genome sequencing and fluorescence in situ hybridisation analysis confirmed disruption of PTH2R.
Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala.
New
Bethesda, United States. In J Neurosci, Oct 2015
Recent behavioral evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory.
PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women.
New
Exeter, United Kingdom. In Chemosphere, Feb 2015
We used multivariate linear regression models and found that PFOA or PFOS was inversely correlated with parathyroid hormone 2 receptor (PTH2R) expression (coefficients=-0.43 and -0.32, p=p=0.017
Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine.
Malmö, Sweden. In J Bone Miner Metab, 2015
The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women.
International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.
Review
Impact
Pittsburgh, United States. In Pharmacol Rev, 2014
The type-2 parathyroid hormone receptor (PTHR2) binds a peptide ligand, called tuberoinfundibular peptide-39 (TIP39), and while the biologic role of the PTHR2/TIP39 system is not as defined as that of the PTHR1, it likely plays a role in the central nervous system as well as in spermatogenesis.
Expression of osteogenic molecules in the caudate nucleus and gray matter and their potential relevance for Basal Ganglia calcification in hypoparathyroidism.
New Delhi, India. In J Clin Endocrinol Metab, 2014
The mRNA expression of bone transcription factors (RUNX2/osterix), bone morphogenetic proteins (BMPs) 2 and 4, osteonectin, osteopontin, osteocalcin, vitamin D receptor, calcium sensing-receptor, Na phosphate transporters (PiTs) 1 and 2, N-methyl-D-aspartate receptor 2B (NMDAR2B), carbonic anhydrase II (CA-II), PTH1 receptor (PTH1R), PTH2R, and PTHrP were assessed by RT-PCR.
Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility.
In Arthritis Res Ther, 2013
Online Mendelian Inheritance in Man (OMIM) and Database of Single Nucleotide Polymorphisms (dbSNP) Short Genetic Variations databases were used to select gene regions containing the following polymorphisms to analyze: FRZB rs288326 and rs7775, MATN3 rs77245812, ASPN D14 repeats, PTHR2 rs76758470, GDF5 rs143383 and DVWA rs11718863.
Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation.
Budapest, Hungary. In Psychoneuroendocrinology, 2013
Since TIP39-containing fibers and the receptor for TIP39, the parathyroid hormone 2 receptor (PTH2 receptor) are abundant in the arcuate nucleus and the medial preoptic area, we antagonized TIP39 action locally to reveal its actions.
Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues.
Bethesda, United States. In Proc Natl Acad Sci U S A, 2013
These areas are enriched in its receptor, the parathyroid hormone 2 receptor (PTH2R).
A proteomics and transcriptomics approach to identify leukemic stem cell (LSC) markers.
Groningen, Netherlands. In Mol Cell Proteomics, 2013
We identified 867 and 610 unique CD34(+) PM (-associated) proteins in these AML samples respectively, including previously described proteins such as CD47, CD44, CD135, CD96, and ITGA5, but also novel ones like CD82, CD97, CD99, PTH2R, ESAM, MET, and ITGA6.
PTH-receptors regulate norepinephrine release in human heart and kidney.
GeneRIF
Düsseldorf, Germany. In Regul Pept, 2011
PTH-receptors regulate norepinephrine release in human heart and kidney
Novel potential regulators of maternal adaptations during lactation: tuberoinfundibular peptide 39 and amylin.
Review
Budapest, Hungary. In J Neuroendocrinol, 2011
TIP39 is the ligand of the parathyroid hormone 2 receptor (PTH2 receptor) is induced in the posterior intralaminar complex of the thalamus (PIL) during lactation.
Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development.
GeneRIF
Bethesda, United States. In J Neuroendocrinol, 2011
Involvement of the TIP39/PTH2-R system in the pathways involved in the successful development of the pups.
The TIP39-PTH2 receptor system: unique peptidergic cell groups in the brainstem and their interactions with central regulatory mechanisms.
Review
Budapest, Hungary. In Prog Neurobiol, 2010
Tuberoinfundibular peptide of 39 residues (TIP39) is the recently purified endogenous ligand of the previously orphan G-protein coupled parathyroid hormone 2 receptor (PTH2R).
Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human.
GeneRIF
Budapest, Hungary. In Neuroscience, 2009
The results demonstrate that TIP39 and the PTH2R are expressed in the brain of primates in locations that suggest involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception.
Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor.
GeneRIF
Leeds, United Kingdom. In Mol Pharmacol, 2008
Different receptor subtype properties were used to demonstrate that residue 41 in PTH-1R, when either the native Leu or substituted by Ile or Met, can accommodate either Phe or Trp at position 23 of the ligand.
Evidence for the expression of parathyroid hormone 2 receptor in the human brainstem.
GeneRIF
Budapest, Hungary. In Ideggyogy Sz, 2008
The distribution of PTH2R-immunoreactive fibers in viscerosensory brain regions is similar to that reported in mouse and rat suggesting a similar role of the PTH2R in human as in rodents.
Clinical endocrinology and metabolism. Receptors for gut peptides.
Review
Edinburgh, United Kingdom. In Best Pract Res Clin Endocrinol Metab, 2004
Recent discoveries include the identification of receptors for the peptides motilin and neuromedin U, and new physiological ligands for the PTH2 receptor, the CRF(2) receptor and the growth hormone secretagogue receptor.
Harnessing the parathyroids to create stronger bones.
Review
Jerusalem, Israel. In Curr Opin Nephrol Hypertens, 2004
In fact there is more than one receptor - the PTH2 receptor and a putative carboxy-terminal PTH receptor.
