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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Parathyroid hormone 1 receptor

PTH receptor, parathyroid hormone receptor, PTH1R, PTHR1, PTHR
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Parathyroid Hormone, Parathyroid Hormone-Related Protein, CAN, V1a, HAD
Papers on PTH receptor
A Comparison of Phosphospecific Affinity Reagents Reveals the Utility of Recombinant Forkhead-associated Domains in Recognizing Phosphothreonine-containing Peptides.
Kay et al., Chicago, United States. In N Biotechnol, Feb 2016
The library yielded binding variants against 9 targets (64% success rate); success was largely determined by what residue occurred at the +3 position (C-terminal) to the pThr moiety (i.e., pT+3).
Mechanisms of vasodilation to PTH 1-84, PTH 1-34, and PTHrP 1-34 in rat bone resistance arteries.
Prisby et al., Arlington, United States. In Osteoporos Int, Feb 2016
Vasodilation was also determined following endothelial cell removal (i.e., denudation), PTH 1 receptor (PTH1R) inhibition and to sodium nitroprusside (SNP; a nitric oxide [NO] donor).
Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism.
Chang et al., San Francisco, United States. In Semin Cell Dev Biol, Jan 2016
UNASSIGNED: Parathyroid hormone (PTH)-related peptide (PTHrP) controls the pace of pre- and post-natal growth plate development by activating the PTH1R in chondrocytes, while PTH maintains mineral and skeletal homeostasis by modulating calciotropic activities in kidneys, gut, and bone.
Bovine parathyroid hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R.
Shi et al., Guangzhou, China. In Int J Mol Med, Jan 2016
In addition, we confirmed the existence of parathyroid hormone 1 receptor (PTH1R) in osteoclasts using three different methods (RT-qPCR, western blot analysis and immunofluorescence staining).
PTH-Induced Osteoblast Proliferation Requires Upregulation of the Ubiquitin-Specific Peptidase 2 (Usp2) Expression.
Ezura et al., Tokyo, Japan. In Calcif Tissue Int, Jan 2016
Usp2 is a deubiquitination enzyme targeting various factors including CyclinD1 in cancer cells and PTH receptor 1 in osteoblasts.
PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
Spiegelman et al., Boston, United States. In Cell Metab, Jan 2016
Fat-specific knockout of PTHR blocked adipose browning and wasting.
PTH receptor-1 signalling-mechanistic insights and therapeutic prospects.
Gardella et al., Madison, United States. In Nat Rev Endocrinol, Dec 2015
Parathyroid hormone/parathyroid hormone-related protein receptor (PTH/PTHrP type 1 receptor; commonly known as PTHR1) is a family B G-protein-coupled receptor (GPCR) that regulates skeletal development, bone turnover and mineral ion homeostasis.
[Regulation of bone metabolism in osteoporosis : Novel drugs for osteoporosis in development].
Seefried et al., Würzburg, Germany. In Unfallchirurg, Nov 2015
Bone formation is stimulated by bone morphogenetic proteins (BMP) and via the parathyroid hormone receptor and the Wnt signaling pathway.
Ollier Disease: Pathogenesis, Diagnosis, and Management.
Arya et al., In Orthopedics, Jun 2015
Recently, heterozygous mutations of PTHR1, IDH1 (most common), and/or IDH2 genes have been suggested by various authors as genetic aberrations.
International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.
Vilardaga et al., Pittsburgh, United States. In Pharmacol Rev, 2014
The type-1 parathyroid hormone receptor (PTHR1) is a family B G protein-coupled receptor (GPCR) that mediates the actions of two polypeptide ligands; parathyroid hormone (PTH), an endocrine hormone that regulates the levels of calcium and inorganic phosphate in the blood by acting on bone and kidney, and PTH-related protein (PTHrP), a paracrine-factor that regulates cell differentiation and proliferation programs in developing bone and other tissues.
Role of Regulators of G Protein Signaling Proteins in Bone Physiology and Pathophysiology.
Li et al., Birmingham, United States. In Prog Mol Biol Transl Sci, 2014
In skeletal development and bone homeostasis as well as in many bone disorders, RGS proteins control the functions of various GPCRs, including the parathyroid hormone receptor type 1 and calcium-sensing receptor and also regulate various critical signaling pathways, such as Wnt and calcium oscillations.
Backbone modification of a polypeptide drug alters duration of action in vivo.
Gellman et al., Madison, United States. In Nat Biotechnol, 2014
Using an agonist of parathyroid hormone receptor-1 (PTHR1), a G protein-coupled receptor in the B-family, we present an approach for α→β residue replacement that enables both high activity and improved pharmacokinetic properties in vivo.
The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq signaling.
Klenk et al., Würzburg, Germany. In Mol Pharmacol, 2012
Vav2 specifically interacted with activated Galpha(q) but not with Galpha(s) subunits, competing with PTHR for coupling to Galpha(q).
The parathyroid hormone receptorsome and the potential for therapeutic intervention.
Mahon, United States. In Curr Drug Targets, 2012
[review] The PTH1R carboxy-terminal tail directs interactions with a plethora of binding partners, resulting in the activation of many pathways.
Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting.
Friedman et al., Pittsburgh, United States. In J Bone Miner Res, 2011
PTH(1-34) promotes coupled PTHR ubiquitination and deubiquitination, whereas PTH(7-34) activates only ubiquitination, thereby leading to PTHR downregulation.
Effects of nicotine on PTHrP and PTHrP receptor expression in rat coronary endothelial cells.
Schlüter et al., Gießen, Germany. In Cell Physiol Biochem, 2011
Nicotine induces PTHrP expression in endothelial cells but excessive concentrations of nicotine reduce PTHrP receptor expression thereby attenuating any protective effects of PTHrP against apoptosis.
Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains.
Friedman et al., Pittsburgh, United States. In J Biol Chem, 2011
Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains
TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling.
Cao et al., Baltimore, United States. In Nat Cell Biol, 2010
TGFBR2 forms an endocytic complex with PTH1R in response to PTH and regulates signalling by PTH and TGF-beta. TGFBR2 directly phosphorylates the PTH1R cytoplasmic domain, which modulates PTH-induced endocytosis of the PTH1R-TGFBR2 complex.
PTH battles TGF-beta in bone.
Baron et al., Paris, France. In Nat Cell Biol, 2010
PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-beta type II receptor (TbetaRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-beta and PTH signalling in vivo.
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