Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism.
San Francisco, United States. In Semin Cell Dev Biol, Jan 2016
UNASSIGNED: Parathyroid hormone (PTH)-related peptide (PTHrP) controls the pace of pre- and post-natal growth plate development by activating the PTH1R in chondrocytes, while PTH maintains mineral and skeletal homeostasis by modulating calciotropic activities in kidneys, gut, and bone.
PTH receptor-1 signalling-mechanistic insights and therapeutic prospects.
Madison, United States. In Nat Rev Endocrinol, Dec 2015
Parathyroid hormone/parathyroid hormone-related protein receptor (PTH/PTHrP type 1 receptor; commonly known as PTHR1) is a family B G-protein-coupled receptor (GPCR) that regulates skeletal development, bone turnover and mineral ion homeostasis.
Role of Regulators of G Protein Signaling Proteins in Bone Physiology and Pathophysiology.
Birmingham, United States. In Prog Mol Biol Transl Sci, 2014
In skeletal development and bone homeostasis as well as in many bone disorders, RGS proteins control the functions of various GPCRs, including the parathyroid hormone receptor type 1 and calcium-sensing receptor and also regulate various critical signaling pathways, such as Wnt and calcium oscillations.
PTH battles TGF-beta in bone.
Paris, France. In Nat Cell Biol, 2010
PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-beta type II receptor (TbetaRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-beta and PTH signalling in vivo.