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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Phosphatase and tensin homolog

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, TNS, V1a, CAN
Papers using PTEN antibodies
Oxidative stress and mitochondrial dysfunction in sepsis: a potential therapy with mitochondria-targeted antioxidants.
Bozza Patricia, In PLoS ONE, 2008
... phospho-Akt (Ser473), p38 MAPK, phospho-p38 MAPK (Thr180/Tyr182), JNK, phospho-JNK (Thr183/Tyr185), ERK1/2, phospho-ERK1/2 (Thr185/Tyr187), PTEN, and phospho-PTEN (Ser380) were purchased from Cell Signaling Technology, Inc ...
Mitochondria and cellular oxygen sensing and the HIF pathway
Eng Charis et al., In Human Molecular Genetics, 2007
... Antibodies used were α-PTEN monoclonal antibody clone 6H2.1 (Cascade Biosciences, Portland, OR), phospho-PTEN, α-tubulin and α-PARP-1 antibody (Cell Signaling Technologies, Danvers, MA) ...
Cell polarity in development and cancer.
Thi Thu Nguyen Hang, In PLoS ONE, 2006
... The antibodies for detection of PTEN (A2B1), HNF1α (C-19) and HNF4α (C-19) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome
Ardizzoni A et al., In British Journal of Cancer, 2006
... m-thick tissue sections of paraffin-embedded specimens by using a PTEN rabbit monoclonal antibody (Millipore, Billerica, MA, USA) and a pAKT (Ser 473) rabbit monoclonal antibody (Cell Signaling Technology, Beverly, MA, USA), ...
Cell biology. GSK-3beta and microtubule assembly in axons
Campbell F C et al., In British Journal of Cancer, 2004
... Rabbit monoclonal anti-PTEN, anti-GSK3β and -p-GSK3β (Ser9) primary antibodies were purchased from Cell Signaling Technology (New England Biolabs ...
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Papers on PTEN
Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN/PI3K/Akt Signaling Pathway.
Li et al., Nanning, China. In Cell Physiol Biochem, Feb 2016
BACKGROUND/AIMS: Phosphatase and tensin homolog deleted on chromosome ten (PTEN) has been recognized as a promoter of apoptosis in various tissues, and revealed to be up-regulated in circumstances of coronary microembolization (CME).
Profilin-PTEN interaction suppresses NF-kappa B activation via inhibition of IKK phosphorylation.
Manna et al., Hyderābād, India. In Biochem J, Feb 2016
Co-localisation and co-immunoprecipitation studies suggest that Profilin interacts with a protein phosphatase, PTEN and protects it from degradation.
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca(2+) signaling.
Bultynck et al., Leuven, Belgium. In Biochim Biophys Acta, Feb 2016
An important aspect of this is the identification of several major oncogenes, including Bcl-2, Bcl-XL, Mcl-1, PKB/Akt, and Ras, and tumor suppressors, such as p53, PTEN, PML, BRCA1, and Beclin 1, as direct and critical regulators of Ca(2+)-transport systems located at the ER membranes, including IP3 receptors and SERCA Ca(2+) pumps.
Reaching the brain: Advances in optic nerve regeneration.
Goldberg et al., In Exp Neurol, Jan 2016
More recently, some degree of regeneration has been achieved through the optic nerve itself by factors associated with intraocular inflammation (oncomodulin) or by altering levels of particular transcription factors (Klf-4, -9, c-myc), cell-intrinsic suppressors of axon growth (PTEN, SOCS3), receptors to cell-extrinsic inhibitors of axon growth (Nogo receptor, LAR, PTP-σ) or the intracellular signaling pathway activated by these receptors (RhoA).
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Guo et al., Wuhan, China. In Nat Immunol, Jan 2016
UNASSIGNED: The gene encoding PTEN is one of the most frequently mutated tumor suppressor-encoding genes in human cancer.
Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells.
Erlebacher et al., New York City, United States. In Cancer Cell, Jan 2016
Using a mouse model of PTEN-deficient uterine cancer, we describe a surprising inhibitory role for PMNs in epithelial carcinogenesis.
Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults With Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study.
Dombret et al., Marseille, France. In J Clin Oncol, Jan 2016
Multivariate analysis identified serum lactate dehydrogenase level and the NOTCH1/FBXW7/RAS/PTEN oncogene (a four-gene oncogenetic classifier) status but not positron emission tomography or hematopoietic stem cell transplant as independent prognostic factors for outcome in T-LL.
The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR-21 and promoter methylation.
Zekavatian et al., Gorgān, Iran. In J Biomed Sci, Dec 2015
BACKGROUND: PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis.
The critical roles of miR-21 in anti-cancer effects of curcumin.
Chen et al., Australia. In Ann Transl Med, Dec 2015
Several downstream pathways of miR-21 have been identified including phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), programmed cell death protein 4 (PDCD4) and NF-κB pathways.
2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis.
Li et al., Zhenjiang, China. In Oncol Lett, Dec 2015
Additional mechanistic studies of two biomarkers, phosphatase and tensin homolog (PTEN) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)), in prostate cancer revealed that TFC treatment significantly upregulated the expression of PTEN and p27(Kip1).
Somatic Copy Number Alterations at Oncogenic Loci Show Diverse Correlations with Gene Expression.
Kwong et al., Houston, United States. In Sci Rep, Dec 2015
The majority of oncogenes required only amplitude cutoffs, as high amplitude samples were almost invariably focal; however, CDKN2A and PTEN uniquely required both amplitude and length cutoffs as primary predictors.
The Role of PTEN in Myeloid Malignancies.
Saglio et al., Orbassano, Italy. In Hematol Rep, Dec 2015
PTEN deletion in the mouse and in the zebrafish highlights the essential role of this tumor suppressor in the development of myeloid malignancies, in particular acute myeloid leukemia and myeloproliferative disorders.
The Genetic Evolution of Melanoma from Precursor Lesions.
Bastian et al., Australia. In N Engl J Med, Dec 2015
PTEN and TP53 mutations were found only in advanced primary melanomas.
Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis.
Kang et al., Princeton, United States. In Cancer Cell, Dec 2015
Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.
Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective.
Shin et al., Seoul, South Korea. In Int J Mol Sci, 2014
The tumor-specific overexpression of TOB1 results in the activation of other tumor suppressor proteins, such as mothers against decapentaplegic homolog 4 (SMAD4) and phosphatase and tensin homolog-10 (PTEN), and blocks tumor progression.
MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN.
Xu et al., Tianjin, China. In Biochim Biophys Acta, 2012
Our study demonstrated that miR-26a enhanced lung cancer cell metastasis potential via modulation of metastasis-related gene expression, and activation of AKT pathway by PTEN suppression
DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats.
Li et al., Hefei, China. In Toxicol Appl Pharmacol, 2012
DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats
PTEN mutations as a cause of constitutive insulin sensitivity and obesity.
Gloyn et al., Oxford, United Kingdom. In N Engl J Med, 2012
We demonstrate an apparently divergent effect of PTEN mutations: increased risks of obesity and cancer but a decreased risk of type 2 diabetes owing to enhanced insulin sensitivity.
Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects.
Baker et al., Memphis, United States. In Development, 2012
Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects.
[Immunomorphologic features of epithelial-stromal relationships at hyperplasia and endometrial carcinoma].
Kogan et al., In Arkh Patol, 2012
Based on these results we have formulated a hypothesis about the different types of endometrial hyperplasia morphogenesis and its possible transfer to cervical cancer associated with features of tumor suppressor gene PTEN.
More papers using PTEN antibodies
Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
Naeher Tonniele M. et al., In Purinergic Signalling, 2004
... This method has been used to detect activity of protein phosphatases such as PTEN [17] and lipid phosphatases [18] and is based on sensitive detection of low levels of Pi using the BIOMOL GREEN reagent, an enhanced ...
Study on construction of pegfr-hPTEN expression vector induced by irradiation and anti-tumor effect in vitro
Wang Chang-Li et al., In Journal of Experimental & Clinical Cancer Research : CR, 2002
... Primary antibodies against phospho-EGFR and PTEN were obtained from Santa Cruz Biotechnology, Inc ...
Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation.
Rieux-Laucat Frederic, In PLoS ONE, 1999
... obtained from Santa Cruz Biotechnology (CA, USA), anti-phospho-Akt from Upstate (Milipore, Molsheim, France), anti-Akt, and anti-PTEN from Cell Signaling (Ozyme, Saint Quentin Yvelines, ...
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