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Serine peptidase inhibitor, Kazal type 1

PstI, Arylsulfotransferase, SULT1A1, phenol sulfotransferase
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, POLYMERASE, AGE
Papers using PstI antibodies
The actin nucleation factor JMY is a negative regulator of neuritogenesis.
Freitag Nancy E., In PLoS ONE, 2010
... The resulting PCR product was subcloned into the BsaAI and PstI sites in pMW1650.pRIE
Yeast mating: a model system for studying cell and nuclear fusion
Rose Mark D. et al., In The Journal of Cell Biology, 2007
... This fragment was cloned into the SalI and PstI sites of pPROTet.E133 (Clontech Laboratories, Inc.).
ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis
Martin Thomas F.J. et al., In The Journal of Cell Biology, 2001
... The PCR product was cleaved with HindIII and PstI and inserted into HindIII-PstI–digested pEGFP-N1 (CLONTECH Laboratories, Inc.) ...
Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells
Henis Yoav I. et al., In The Journal of Cell Biology, 1997
... prepared similarly, by inserting the respective full-length cDNAs of the human Ras isoforms into the PstI-BamHI sites of pEGFP-C3 (CLONTECH Laboratories, Inc.), after the ...
A rapid DNA isolation procedure for small quantities from fresh leaf tissue.
Yin Tongming, In PLoS ONE, 1986
... HF-PstI (High-Fidelity) and 8 U of MspI (New England BioLabs Inc., Ipswich, MA 01938) ...
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Papers on PstI
Ethanol and 4-Methylpyrazole Increase DNA Adduct Formation of Furfuryl Alcohol in FVB/N Wild-type Mice and in Mice Expressing Human Sulfotransferases 1A1/1A2.
Monien et al., Potsdam, Germany. In Carcinogenesis, Feb 2016
Here, we investigated the impact of ethanol and the ADH inhibitor 4-methylpyrazole on the DNA adduct formation by FFA in wild-type and in humanized mice that were transgenic for human SULT1A1/1A2 and deficient in the mouse (m) Sult1a1 and Sult1d1 genes (h1A1/1A2/1a1(-)/1d1(-)).
Identification of Human Sulfotransferases involved in Lorcaserin N-Sulfamate Formation.
Chen et al., Nieder-Ingelheim, Germany. In Drug Metab Dispos, Feb 2016
Human sulfotransferases (SULTs) SULT1A1, SULT1A2, SULT1E1 and SULT2A1 are involved in the formation of lorcaserin N-sulfamate.
Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism.
Wright et al., Newcastle upon Tyne, United Kingdom. In Toxicol Lett, Jan 2016
To this end we therefore examined the bioactivation of the model hepatic (hepato- and cholangio-) carcinogen estragole and its proximate SULT1A1-activated genotoxic metabolite 1'-hydroxyestragole.
Bisphenol a sulfonation is impaired in metabolic and liver disease.
King et al., Kingston, Jamaica. In Toxicol Appl Pharmacol, Jan 2016
In addition to BPA sulfonation activity, Sult1a1 protein expression decreased by 97% in obese mouse livers.
Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis.
Liu et al., Toledo, United States. In J Appl Toxicol, Jan 2016
A systematic analysis revealed that of the 13 known human SULTs, SULT1A1 SULT1A2, SULTA3, and SULT1B1 are capable of mediating the sulfation of benzyl alcohol.
Emerging Roles of SPINK1 in Cancer.
Stenman et al., Helsinki, Finland. In Clin Chem, Jan 2016
In the SPINK family TATI/PSTI is SPINK1, which is the name used in this review.
The Design and Interpretation of Human SULT1A1 Assays.
Leyh et al., In Drug Metab Dispos, Jan 2016
Very recent work has revealed that the caps of the SULT1A1 are controlled by homotropic allosteric interactions between PAPS molecules bound at the dimer's active sites.
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Feng et al., Tianjin, China. In Curr Drug Metab, 2014
The polymorphisms CYP1A1 (-3801T/C and -4889A/G), and CYP2E1 (PstI/Rsa and 9-bp insertion) have an association with higher risk colon cancers, whereas CYP1A2 (-163C/A and -3860G/A) polymorphism is found to be among the protective factors.
Distribution of the most Common Genetic Variants Associated with a Variable Drug Response in the Population of the Republic of Macedonia.
Dimovski et al., Скопје, Macedonia. In Balkan J Med Genet, 2014
This study summarizes our current knowledge about the frequency distribution of the most common allelic variants in three broad gene categories: the Phase I oxidation-cytochrome P450 (CYP450) family (CYP2C9, CYP2C19, CYP3A5, CYP2D6); the Phase II conjugation (GSTT1, SULT1A1; UGT1A1) and drug target (TYMS-TSER, MTHFR and VKORC1) in the population of the Republic of Macedonia and compares the information obtained with data published for other indigenous European populations.
Distribution of genetic polymorphisms of genes encoding drug metabolizing enzymes & drug transporters - a review with Indian perspective.
Adithan et al., Pondicherry, India. In Indian J Med Res, 2014
This review was intended to compile the normative frequency distribution of the variants of genes encoding DMEs (CYP450s, TPMT, GSTs, COMT, SULT1A1, NAT2 and UGTs) and transporter proteins (MDR1, OCT1 and SLCO1B1) with Indian perspective.
Screening of R122H and N29I mutations in the PRSS1 gene and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis.
Sánchez-Corona et al., Colima, Mexico. In Pancreas, 2012
Data show that pediatric patients bearing the N34S G allele exhibited a 10-fold increased risk of developing acute pancreatitis (AP) compared with controls, suggesting that the SPINK1 N34S mutation represents an etiologic risk factor for AP.
Tumour-associated trypsin inhibitor TATI is a prognostic marker in colorectal cancer.
Haglund et al., Helsinki, Finland. In Oncology, 2011
TATI may protect the tissue from destruction and thereby from tumour spread in colorectal cancer.
SULT1A1 Arg213His polymorphism and lung cancer risk: a meta-analysis.
Wang et al., Shanghai, China. In Asian Pac J Cancer Prev, 2011
Arg213His polymorphism is not associated with lung cancer.
SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?
Kataja et al., Kuopio, Finland. In Bmc Cancer, 2011
We observed a previously unreported association between the SULT1A1 rs9282861 genotype and overall survival of breast cancer patients treated with adjuvant chemotherapy or tamoxifen.
The N34S mutation of the SPINK1 gene and alcoholic chronic pancreatitis.
Korolczuk et al., Lublin, Poland. In Pol Arch Med Wewn, 2011
The N34S mutation of the SPINK1 gene seems to be significantly correlated with alcoholic chronic pancreatitis.
Amplification refractory mutation system for prenatal diagnosis and carrier assessment in cystic fibrosis.
Markham et al., Cheshire, United States. In Lancet, 1990
The nucleotide sequence of both alleles of the PstI restriction fragment length polymorphism at the KM19 locus, which displays linkage disequilibrium with cystic fibrosis, has been determined.
Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia.
Karathanasis et al., In N Engl J Med, 1986
We identified a PstI restriction-endonuclease site flanking the human apolipoprotein A-I gene at its 3' end that is polymorphic.
Isolation of a feline leukaemia provirus containing the oncogene myc from a feline lymphosarcoma.
Casey et al., In Nature, 1984
We used the 1.5 kilobase (kb) PstI fragment of MC29 v-myc in Southern blot analysis to characterize the structure of the c-myc locus in the DNA of 31 naturally occurring feline lymphomas.
Computer-based characterization of epidermal growth factor precursor.
Johnson et al., In Nature, 1984
The sequence of epidermal growth factor has been reported to be similar to that of pancreatic secretory trypsin inhibitor (PSTI) and a somewhat better match has been found with part of the sequence of bovine factor X, one of the blood coagulating factors.
HLA-D region beta-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals.
Ludvigsson et al., In Nature, 1983
Among the HLA-DR 4 and 3/4 individuals, the IDDM patients showed an increased frequency of a PstI 18 kilobase (kb) fragment.
More papers using PstI antibodies
Formulas and recipes
Waldor Matt, In PLoS Biology, 1971
... KpnI-PstI restriction sites on the multicloning site (MCS) of pQE-30 plasmid (Qiagen) bearing an ampicillin resistance ...
Construction and properties of Escherichia coli strains exhibiting alpha-complementation of beta-galactosidase fragments in vivo.
Isalan Mark, In PLoS ONE, 1971
... We Qiaquick gel purified this PCR product, digested it with XbaI and PstI, and then performed a Qiagen ERC cleanup on the ...
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