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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Selectin P ligand

PSGL-1, P-selectin glycoprotein ligand-1, CD162
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: P-selectin, CD45, L-selectin, CAN, E-selectin
Papers using PSGL-1 antibodies
Multifunctional Surfaces with Discrete Functionalized Regions for Biological Applications
Stebe Kathleen J. et al., In Langmuir, 2005
... Anti-CD66de (COL-1), anti-CD162 (KPL-1), PE-conjugated anti-CD162 (KPL-1-PE), PE-conjugated anti-CD66acde (B1.1-PE), and PE-conjugated anti-CD62E (68-5H11) mAbʼs, PE-conjugated mouse IgG, and FITC-conjugated mouse IgG were from BD Biosciences.
Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties
Rooijakkers Suzan H M et al., In The EMBO Journal, 1996
... CD87 (VIM5, BD), CD88 (S5/1, Biolegend), CD89 (Mip8a, Abd-Serotec), CD114 (LMM741, BD), CD119 (GIR-208, BD), CD162 (KPL-1, BD), CD181 (42705.111,
Papers on PSGL-1
Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis.
Zhao et al., Irvine, United States. In Biomaterials, Jan 2016
Previously, we reported that engineered MSCs expressing P-selectin glycoprotein ligand-1 (PSGL-1) and Sialyl-Lewis(x) (SLeX) via mRNA transfection facilitated the targeted delivery of anti-inflammatory cytokine interleukin-10 (IL-10) to inflamed ear.
CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.
Alcaide et al., Boston, United States. In J Immunol, Jan 2016
We demonstrate Th17 cells express CD44, P-selectin glycoprotein ligand (PSGL)-1, and CD43.
Extracellular Fibrinogen Binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes.
Pula et al., Bath, United Kingdom. In J Biol Chem, Jan 2016
Efb-N interaction with P-selectin inhibited P-selectin binding to its physiological ligand, P-selectin glycoprotein ligand-1 (PSGL-1), both in cell lysates and in cell-free assays.
Regulation of L-selectin-dependent hydrodynamic shear thresholding by leukocyte deformability and shear dependent bond number.
Lawrence et al., Charlottesville, United States. In Biorheology, Dec 2015
Adhesive interactions between flowing and adherent leukocytes are mediated by L-selectin and P-selectin Glycoprotein Ligand-1 (PSGL-1) co-expressed on the leukocyte surface and ultimately regulated by hydrodynamic shear thresholding.
Adhesive Mechanisms of Histone-Induced Neutrophil-Endothelium Interactions in the Muscle Microcirculation.
Thorlacius et al., Lund, Sweden. In Eur Surg Res, Dec 2015
METHODS: Histone 3 and TNF-α were intrascrotally administered, and anti-P-selectin, anti-P-selectin glycoprotein ligand-1 (PSGL-1), anti-membrane-activated complex-1 (Mac-1), anti-lymphocyte function antigen-1 (LFA-1) antibody and neutrophil depletion antibody were injected intravenously or intraperitoneally.
Role of the endothelial surface layer in neutrophil recruitment.
Ley et al., Los Angeles, United States. In J Leukoc Biol, Oct 2015
These molecules support neutrophil rolling via binding of PSGL-1 and other ligands on neutrophils.
Central nervous system niche involvement in the leukemia.
Ahmadzadeh et al., Ahvāz, Iran. In Clin Transl Oncol, Sep 2015
Given the importance of prognosis and early diagnosis of CNS involvement in leukemias as well as the severe side effects of current treatments, diagnostic and therapeutic approaches should focus on identification and inhibition of the factors contributing to CNS involvement, including CXCR3, P-selectin glycoprotein ligand-1 and MCP1.
Neutrophils scan for activated platelets to initiate inflammation.
Hidalgo et al., Madrid, Spain. In Science, 2015
The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution of receptors that drive neutrophil migration.
[Research advances on ADAM28 expression and ADAM28-mediated tumor metastasis].
Zhang et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2014
ADAM28-mediated cancer cell metastasis may be related with the cleavage of von Willebrand's factor (vWF), insulin-like growth factor binding protein-3 (IGFBP-3) and connective tissue growth factor (CTGF), as well as the promoting PSGL-1/P-selectin-mediated cell adhesion.
Activation states of blood eosinophils in asthma.
Johansson, Madison, United States. In Clin Exp Allergy, 2014
A number of eosinophil surface proteins, including CD69, L-selectin, intercellular adhesion molecule-1 (ICAM-1, CD54), CD44, P-selectin glycoprotein ligand-1 (PSGL-1, CD162), cytokine receptors, Fc receptors, integrins including αM integrin (CD11b), and activated conformations of Fc receptors and integrins, have been proposed to report cell activation.
Cell and tissue tropism of enterovirus 71 and other enteroviruses infections.
Shih et al., Taiwan. In J Biomed Sci, 2013
SCARB2 or PSGL-1 receptor binding is the first step in the development of viral infections, and viral factors (e.g., 5' UTR, VP1, 3C, 3D, 3' UTR), host factors and environments (e.g., ITAFs, type I IFN) are also involved in viral infections.
'Slings' enable neutrophil rolling at high shear.
Ley et al., Los Angeles, United States. In Nature, 2012
We demonstrate slings in a model of acute inflammation in vivo and on P-selectin in vitro, where P-selectin-glycoprotein-ligand-1 (PSGL-1) is found in discrete sticky patches whereas LFA-1 is expressed over the entire length on slings.
Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer.
Nehmann et al., Hamburg, Germany. In Cancer Lett, 2012
E- and P-selectins play a role in spontaneous metastasis formation both into bone marrow and lungs.
Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.
McEver et al., Oklahoma City, United States. In J Biol Chem, 2012
The cytoskeletal independence of PSGL-1-initiated, alpha(L)beta(2)-mediated slow rolling differs markedly from the cytoskeletal dependence of chemokine-initiated, alpha(L)beta(2)-mediated arrest.
The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study.
Stanković et al., Belgrade, Serbia. In Mol Biol Rep, 2012
There is significant association between PSGL-1 Met62Ile polymorphism and advanced carotid atherosclerosis with stenosis in female patients from the Serbian population.
Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.
Bhandoola et al., Philadelphia, United States. In J Immunol, 2012
hematopoietic progenitors lacking fucosyltransferase 4 and 7 do not express functional PSGL-1, and do not home efficiently to the thymus.
Ezrin-radixin-moesin-binding sequence of PSGL-1 glycoprotein regulates leukocyte rolling on selectins and activation of extracellular signal-regulated kinases.
Spertini et al., Lausanne, Switzerland. In J Biol Chem, 2012
PSGL-1 EBS plays a critical role in recruiting leukocytes on selectins and in activating the MAPK pathway, whereas it is dispensable to phosphorylate Syk and to lead to alpha(L)beta(2)-dependent leukocyte slow rolling.
Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling.
Ley et al., Los Angeles, United States. In Nat Methods, 2010
We observed that the footprint of a rolling neutrophil was fourfold larger than previously thought, and that P-selectin-PSGL-1 bonds were relaxed at the leading edge of the rolling cell, compressed under the cell center, and stretched at the trailing edge.
Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71.
Shimizu et al., Tokyo, Japan. In Nat Med, 2009
a role for PSGL-1-positive leukocytes in cell tropism and pathogenesis during the course of foot and mouth disease and other EV71-mediated diseases.
A role for leukocyte-endothelial adhesion mechanisms in epilepsy.
Constantin et al., In Nat Med, 2008
Using a mouse model of epilepsy, we show that seizures induce elevated expression of vascular cell adhesion molecules and enhanced leukocyte rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1 (PSGL-1, encoded by Selplg) and leukocyte integrins alpha(4)beta(1) and alpha(L)beta(2).
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