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Pregnancy specific beta-1-glycoprotein 6

PSG6, PSG12, Cgm3, PSGGB, PSG10
The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] (from NCBI)
Top mentioned proteins: PSG, CD45, PSG11, CEA, ACID
Papers on PSG6
Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes.
Dveksler et al., Bethesda, United States. In Am J Reprod Immunol, 2001
METHOD OF STUDY: Human monocytes and murine RAW 264.7 cells were treated with recombinant PSG1, PSG6, PSG11, or a truncated PSG6 consisting of only the N-terminal domain (PSG6N).
Genetic maps of polymorphic DNA loci on rat chromosome 1.
Wilder et al., Bethesda, United States. In Genomics, 1996
Thirteen gene loci (Myl2, Aldoa, Tnt, Igf2, Prkcg, Cgm4, Calm3, Cgm3, Psbp1, Sa, Hbb, Ins1, and Tcp1) were previously mapped.
Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants.
Hammarström et al., Umeå, Sweden. In Biochem Biophys Res Commun, 1995
PSG1, PSG4, PSG5 were found at highest frequency while PSG8 and PSG12 cDNA clones were not detected.
Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region.
Hammarström et al., Livermore, United States. In Genomics, 1994
Detailed restriction mapping and hybridization with gene-specific probes indicated that the order of the 11 Previously identified PSG genes is cen-PSG3-PSG8-PSG12-PSG1-PSG6-PSG7-+ ++PSG13-PSG2-PSG5-PSG4-PSG11-tel.
Subtle differences in human pregnancy-specific glycoprotein gene promoters allow for differential expression.
Chou et al., Bethesda, United States. In J Biol Chem, 1994
We have shown previously that nucleotides -172 to -34 with respect to the translation start site constitute a minimal promoter in the PSG12 gene (class 1).
Pregnancy-specific glycoprotein gene expression and the induction by 5-bromo-2'-deoxyuridine.
Chou et al., Bethesda, United States. In Biochemistry, 1994
Moreover, in transient expression assays, BudR increased chloramphenicol acetyltransferase (CAT) expression directed by PSG1-I, PSG4, PSG5, PSG6, and PSG11 promoter-CAT fusion genes.(ABSTRACT
Characterization of two allelic variants of a human pregnancy-specific glycoprotein gene.
Chou et al., Bethesda, United States. In J Biol Chem, 1993
Two overlapping PSG cosmid clones, which contain two allelic variants of a PSG gene (PSG12 and PSG12 psi), were isolated from an unamplified library made from a single individual.
Immortalization of virus-free human placental cells that express tissue-specific functions.
Chou et al., Bethesda, United States. In Mol Endocrinol, 1992
To characterize PSG promoter activity, we constructed chloramphenicol acetyltransferase (CAT) fusion genes containing -809 to -44 basepairs up-stream of the translational start site of the PSG6 gene.
The pregnancy-specific glycoprotein family of the immunoglobulin superfamily: identification of new members and estimation of family size.
Hammarström et al., Umeå, Sweden. In Genomics, 1992
They are PSG1, PSG2, PSG3, PSG4, PSG5, PSG6, PSG7, PSG8, PSG11, PSG12, and PSG13.
Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit.
Elting et al., West Haven, United States. In Biochemistry, 1990
We describe the isolation and characterization of two additional PSG cDNAs, PSG9 and PSG10, whose transcripts are largely expressed in placental tissue and to a lesser extent in some other cell types, including myeloid cells differentiated to granulocytes.
Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.
Chou et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 1990
PSGGB corresponds to the previously identified cDNA PSG6, which encodes proteins containing a 34-amino acid leader peptide and a 108-amino acid N domain, which is one amino acid shorter than the majority of PS beta G N domains.
cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver.
Thompson et al., Freiburg, Germany. In Biochem Biophys Res Commun, 1989
They are derived from three closely related genes (PSG1, PSG4 and PSG6).
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