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Discs, large homolog 2

PSD-93, chapsyn-110, DLG2
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008] (from NCBI)
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Top mentioned proteins: PSD-95, CAN, XLMR, SAP97, SAP
Papers using PSD-93 antibodies
Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.
Uversky Vladimir N., In PLoS ONE, 1996
... mouse anti-CHK from BD BioSciences, mouse anti-Src (clone GD11) from Upstate (Lake Placid, NY), rabbit anti-PSD93 from Alomone Labs Ltd., rabbit anti-c-Src (Y215) ...
Papers on PSD-93
Identification of Genes Associated with Papillary Thyroid Carcinoma (PTC) for Diagnosis by Integrated Analysis.
Pang et al., Chongqing, China. In Horm Metab Res, Feb 2016
In the PPI network, MLLT1, DLG2, and EFEMP1 were the hub proteins, in which DLG2 and EFEMP1 were involved in tumor progression.
Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease.
Smit et al., Amsterdam, Netherlands. In Alzheimers Dement, Feb 2016
Early changes were observed in levels of proteins related to cytoskeletal dynamics and synaptic components including an increase in RIMS1 and glutamate receptor, ionotropic kainate 4. Several synaptic proteins, such as BSN, LIN7A, DLG2, -3, and -4, exhibit an early-up, late-down expression pattern.
PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density.
Reese et al., Bethesda, United States. In Proc Natl Acad Sci U S A, Jan 2016
Here, we explore the structural and functional roles of MAGUKs at hippocampal excitatory synapses by simultaneous knocking down PSD-95, PSD-93, and synapse-associated protein (SAP)102 and combining electrophysiology and transmission electron microscopic (TEM) tomography imaging to analyze the resulting changes.
Proteomic analysis of PSD-93 knockout mice following the induction of ischemic cerebral injury.
Zhang et al., Nanjing, China. In Neurotoxicology, Jan 2016
UNASSIGNED: Postsynaptic density protein-93 (PSD-93) is enriched in the postsynaptic density and is involved in N-methyl-d-aspartate receptor (NMDAR) triggered neurotoxicity through PSD-93/NMDAR/nNOS signaling pathway.
Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.
Hirokawa et al., Tsukuba, Japan. In J Neurosci, Dec 2015
Enhanced activity-dependent degradation of PSD-93 and reduced transport of NR2A/2B in dendrites was likely responsible for altered receptor function in neurons lacking MAP1A.
Betaine reverses the memory impairments in a chronic cerebral hypoperfusion rat model.
Xiaojian et al., Zhengzhou, China. In Neurosci Lett, Dec 2015
Betaine also restored the expression of PSD93, PSD95 and MAP2 to preserve the synaptic functions.
Synaptically Localized Mitogen-Activated Protein Kinases: Local Substrates and Regulation.
Wang et al., Kansas City, United States. In Mol Neurobiol, Dec 2015
Central among them are key synaptic scaffold proteins (PSD-95 and PSD-93), cadherin-associated proteins (δ-catenin), Kv4.2 K(+) channels, and metabotropic glutamate receptors.
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism.
Ma et al., Wuhan, China. In Nat Genet, Feb 2015
Beyond recalculating frequencies for the previously reported frequent integration sites POU5F1B (9.7%), FHIT (8.7%), KLF12 (7.8%), KLF5 (6.8%), LRP1B (5.8%) and LEPREL1 (4.9%), we discovered new hot spots HMGA2 (7.8%), DLG2 (4.9%) and SEMA3D (4.9%).
Modeling combined schizophrenia-related behavioral and metabolic phenotypes in rodents.
Olivier et al., Townsville, Australia. In Behav Brain Res, 2015
In this review we focus on selected genetic (DBA/2J mice, leptin receptor mutants, and PSD-93 knockout mice), early neurodevelopmental (maternal protein deprivation) and pharmacological (acute phencyclidine) animal models that capture the combined behavioral and metabolic abnormalities shown by schizophrenic patients.
Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia.
Rujescu et al., Halle, Germany. In Transl Psychiatry, 2014
We then explored whether the human orthologs of these genes are associated with schizophrenia in the largest schizophrenia genome-wide association study published to date, and found evidence for association for 4 out of the 20 genes: SF3B1, FOXP1, DLG2 and VGLL4.
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
Deussing et al., München, Germany. In Plos One, 2014
CRHR1 is co-expressed with the identified MAGUKs and with the additionally investigated PSD93 in neurons of the adult mouse brain and in primary hippocampal neurons, supporting the probability of a physiological interaction in vivo.
The PDZ protein discs-large (DLG): the 'Jekyll and Hyde' of the epithelial polarity proteins.
Marsh et al., Birmingham, United Kingdom. In Febs J, 2012
However, whether mammalian homologues of DLG (DLG1, DLG2, DLG3 and DLG4) also possess tumour suppressor functions is not known.
MAGUKs, synaptic development, and synaptic plasticity.
Petralia et al., Bethesda, United States. In Neuroscientist, 2011
A major example of this is the neuronal synapse, which contains several presynaptic and postsynaptic MAGUKs including PSD-95, SAP102, SAP97, PSD-93, CASK, and MAGIs.
Research progress on neurobiology of neuronal nitric oxide synthase.
Zhu et al., Nanjing, China. In Neurosci Bull, 2011
There are primarily 9 nNOS-interacting proteins, including post-synaptic density protein 95 (PSD95), clathrin assembly lymphoid leukemia (CALM), calcium/calmodulin-dependent protein kinase II alpha (CAMKIIA), Disks large homolog 4 (DLG4), DLG2, 6-phosphofructokinase, muscle type (PFK-M), carboxy-terminal PDZ ligand of nNOS (CAPON) protein, syntrophin and dynein light chain (LC).
Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.
Wollmuth et al., Stony Brook, United States. In J Comp Neurol, 2011
Membrane-associated guanylate kinase homolog PSD-93 is a central organizer of the postsynaptic density at excitatory synapses on pyramidal neurons.
In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.
Grant et al., United Kingdom. In J Neurosci, 2010
These data show critical roles for psd-93 and interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes.
Effect of PSD-95/SAP90 and/or PSD-93/chapsyn-110 deficiency on the minimum alveolar anesthetic concentration of halothane in mice.
Johns et al., Baltimore, United States. In Anesthesiology, 2010
PSD-93 deficiency in knock-out mice results in a decrease in the minimum alveolar anesthetic concentration of halothane.
Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-D-aspartate receptor-triggered neurotoxicity.
Xu et al., Nanjing, China. In Neuroscience, 2010
Since NMDARs, Ca(2+), and NO play a critical role during the development of brain trauma, seizures, and ischemia, the present work suggests that PSD-93 might contribute to molecular mechanisms of neuronal damage in these brain disorders.
Structure of the first PDZ domain of human PSD-93.
Gajhede et al., Copenhagen, Denmark. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010
Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 PDZ1 shows that they are very similar in terms of amino-acid composition
Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.
Bredt et al., United States. In Cell, 1996
Here, we show that the N-terminus of nNOS, which contains a PDZ protein motif, interacts with similar motifs in postsynaptic density-95 protein (PSD-95) and a related novel protein, PSD-93.nNOS and PSD-95 are coexpressed in numerous neuronal populations, and a PSD-95/nNOS complex occurs in cerebellum.
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