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Prostate stem cell antigen

PSCA, Prostate stem cell antigen
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, POLYMERASE, MEN
Papers on PSCA
PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma.
Fu et al., Hong Kong, Hong Kong. In Carcinogenesis, Feb 2016
By high-throughput transcriptome sequencing (RNA-Seq) profiling of 3 pairs of primary ESCCs and their corresponding nontumorous tissues, we identified prostate stem cell antigen (PSCA), a gene that encodes a glycosylphosphatidylinositol (GPI) anchored protein, is significantly down-regulated in ESCC.
Genetic Variation of BCL2 (rs2279115), NEIL2 (rs804270), LTA (rs909253), PSCA (rs2294008) and PLCE1 (rs3765524, rs10509670) Genes and Their Correlation to Gastric Cancer Risk Based on Universal Tagged Arrays and Fe3O4 Magnetic Nanoparticles.
Cui et al., In J Biomed Nanotechnol, Nov 2015
With the help of Fe3O4 nagnetic nanoparticles as a solid carrier and an excellent tool for separation, six SNP loci (rs2279115 of BCL2 gene, rs804270 of NEIL2 gene, rs909253 of LTA gene, rs2294008 of PSCA gene, rs3765524 and rs10509670 of PLCE1 gene) were selected to evaluate their relation to gastric cancer risk.
Loss-of-function variants in ATM confer risk of gastric cancer.
Stefansson et al., Reykjavík, Iceland. In Nat Genet, Aug 2015
Our results confirm an association between gastric cancer in Europeans and three loci previously reported in Asians, MUC1, PRKAA1 and PSCA, refine the association signal at PRKAA1 and support a pathogenic role for the tandem repeat identified in MUC1.
Prostate stem cell antigen variation rs2294008 associated with the risk of bladder cancer.
Weng et al., Ningbo, China. In Int J Clin Exp Med, 2014
Several studies reported Prostate stem cell antigen (PSCA) rs2294008 was susceptibly associated with bladder cancer (BC) risk.
The Quantified Level of Circulating Prostate Stem Cell Antigen mRNA relative to GAPDH Level Is a Clinically Significant Indictor for Predicting Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy.
Lee et al., South Korea. In Biomed Res Int, 2014
The study quantified the relative absolute PSCA level in relation to the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) level in the peripheral blood of 478 hormone-naive prostate cancer (PC) patients who underwent radical prostatectomy from 2005 to 2012 and evaluated its prognostic significance as a risk factor for predicting biochemical recurrence (BCR), compared to known parameters.
Biomarkers for evaluation of prostate cancer prognosis.
Panjehpour et al., Eşfahān, Iran. In Asian Pac J Cancer Prev, 2014
We here selected a group of candidate biomarkers including PSA, PSA velocity, percentage free PSA, TGFβ1, AMACR, chromogranin A, IL-6, IGFBPs, PSCA, biomarkers related to cell cycle regulation, apoptosis, PTEN, androgen receptor, cellular adhesion and angiogenesis, and also prognostic biomarkers with Genomic tests for discussion.
A Multiple Interaction Analysis Reveals ADRB3 as a Potential Candidate for Gallbladder Cancer Predisposition via a Complex Interaction with Other Candidate Gene Variations.
Mittal et al., Kyŏngsan, South Korea. In Int J Mol Sci, 2014
Here, we performed Multifactor-Dimensionality Reduction (MDR) and Classification and Regression Tree Analysis (CRT) to investigate the gene-gene interactions and the combined effect of 14 SNPs in nine genes (DR4 (rs20576, rs6557634); FAS (rs2234767); FASL (rs763110); DCC (rs2229080, rs4078288, rs7504990, rs714); PSCA (rs2294008, rs2978974); ADRA2A (rs1801253); ADRB1 (rs1800544); ADRB3 (rs4994); CYP17 (rs2486758)) involved in various signaling pathways.
Association of a common genetic variant in prostate stem cell antigen with cancer risk.
Hou et al., Suzhou, China. In Arch Med Sci, 2014
INTRODUCTION: Polymorphisms in the prostate stem cell antigen (PSCA) gene have been hypothesized to increase the genetic susceptibility to cancers.
Role of gene polymorphisms in gastric cancer and its precursor lesions: current knowledge and perspectives in Latin American countries.
Chiurillo, Barquisimeto, Venezuela. In World J Gastroenterol, 2014
Other genetic variants recently evaluated in large meta-analyses and associated with gastric cancer risk were also analyzed in a few studies [e.g., prostate stem cell antigen (PSCA), CDH1, Survivin].
Prostate stem cell antigen and cancer risk, mechanisms and therapeutic implications.
Tian et al., Tianjin, China. In Expert Rev Anticancer Ther, 2014
Prostate stem cell antigen (PSCA) was originally identified as a tumor antigen in prostate cancer.
[Possible role of genetic factors on reduced risk for gastric cancer among duodenal ulcer patients].
Nakamura et al., Tokyo, Japan. In Nihon Rinsho, 2013
Recently the association of PSCA and ABO with duodenal ulcer were identified by GWAS in the Japanese population.
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells.
Sadelain et al., New York City, United States. In Nat Biotechnol, 2013
Using the prostate tumor antigens PSMA and PSCA, we show that co-transduced T cells destroy tumors that express both antigens but do not affect tumors expressing either antigen alone.
The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis.
Zhang et al., Nanjing, China. In J Cancer Res Clin Oncol, 2012
Findings suggest that prostate stem cell antigen (PSCA) rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.
Prostate stem cell antigen polymorphisms and susceptibility to gastric cancer: a systematic review and meta-analysis.
Chen et al., Tianjin, China. In Cancer Epidemiol Biomarkers Prev, 2012
The two loci of PSCA (rs2294008 and rs2976392) were both significantly associated with gastric cancer susceptibility and in linkage disequilibrium.
A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.
Matsuda et al., Tokyo, Japan. In Nat Genet, 2012
The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer in a recessive model but was associated with decreased risk of gastric cancer.
Prostate stem cell antigen single nucleotide polymorphisms influence risk of estrogen receptor negative breast cancer in Korean females.
Lee et al., South Korea. In Asian Pac J Cancer Prev, 2011
Associations exist between PSCA SNPs and breast cancer susceptibility in Korean women
Positive and negative regulation of prostate stem cell antigen expression by Yin Yang 1 in prostate epithelial cell lines.
Dubey et al., Winston-Salem, United States. In Plos One, 2011
Two direct YY1 binding sites within the PSCA promoter, an inhibitory upstream site and a downstream site, proximal to the androgen-responsive element, which stimulated PSCA promoter activity.
Detection of prostate stem cell antigen expression in human prostate cancer using quantum-dot-based technology.
Larré et al., Wuhan, China. In Sensors (basel), 2011
intensity of QDs fluorescence remained stable for two weeks (p = 0.083) after conjugation to the PSCA protein, and nearly 93% of positive expression with their fluorescence still could be seen after four weeks
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
Gu et al., In Nat Genet, 2009
Genetic variation in PSCA confers susceptibility to urinary bladder cancer.
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.
Hirohashi et al., In Nat Genet, 2008
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
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