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WAP four-disulfide core domain 1

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, ACID, V1a
Papers on PS20
Probing Shear Thinning Behaviors of IgG Molecules at the Air-Water Interface via Rheological Methods.
Vance et al., Thousand Oaks, United States. In Langmuir, Feb 2016
Likewise the addition of polysorbate 20 (PS20) to the 0.7 mg/mL solutions decreased the degree of shear thinning by disrupting the network structure at the interface.
Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism.
Yadav et al., San Francisco, United States. In Mol Pharm, Dec 2015
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation upon long-term (∼18-36 months) storage of two monoclonal antibody (mAb, mAb-A, and mAb-B) drug products at 2-8 °C.
Understanding Particle Formation: Solubility of Free Fatty Acids as Polysorbate 20 Degradation Byproducts in Therapeutic Monoclonal Antibody Formulations.
Yadav et al., San Francisco, United States. In Mol Pharm, Dec 2015
The purpose of this work was to determine the aqueous solubilities at 2-8 °C of the major free fatty acids (FFAs) formed by polysorbate 20 (PS20) degradation and identify possible ways to predict, delay, or mitigate subsequent particle formation in monoclonal antibody (mAb) formulations.
Using lysine-reactive fluorescent dye for surface characterization of a mAb.
Schöneich et al., San Francisco, United States. In J Pharm Sci, Mar 2015
We then applied our method to study the interaction of the mAb with a common excipient, polysorbate-20 (PS-20).
Free fatty acid particles in protein formulations, part 2: contribution of polysorbate raw material.
Litowski et al., Seattle, United States. In J Pharm Sci, Feb 2015
Polysorbate 20 (PS20) is a nonionic surfactant frequently used to stabilize protein biopharmaceuticals.
WFDC1 is a key modulator of inflammatory and wound repair responses.
Rowley et al., London, United Kingdom. In Am J Pathol, 2014
WFDC1/ps20 is a whey acidic protein four-disulfide core member that exhibits diverse growth and immune-associated functions in vitro.
PAX2 Expression in Ovarian Cancer.
Wong et al., Houston, United States. In Int J Mol Sci, 2012
Microarray analysis indicated that several genes involved in growth inhibition and motility, such as G0S2, GREM1, and WFDC1, were up-regulated in PAX2 knockdown cells.
WFDC1/ps20: a host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection.
Fish et al., Toronto, Canada. In Antiviral Res, 2012
The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection.
Immunotherapy of prostate cancer: identification of new treatments and targets for therapy, and role of WAP domain-containing proteins.
Smith et al., London, United Kingdom. In Biochem Soc Trans, 2011
We discuss the possible role of alternative suppressor molecules, including the WAP (whey acidic protein) homologue ps20 that is expressed on prostate stroma and other WAP domain-containing proteins in the immunosuppressive prostate cancer milieu and discuss novel immunotherapeutic strategies to combat this disease.
War and peace between WAP and HIV: role of SLPI, trappin-2, elafin and ps20 in susceptibility to HIV infection.
Rosenthal et al., Hamilton, Canada. In Biochem Soc Trans, 2011
The present review highlights the role and significance of the serine protease inhibitors SLPI (secretory leucocyte protease inhibitor), trappin-2, elafin and ps20 (prostate stromal protein 20 kDa) in HIV susceptibility and infection.
The WFDC1 gene: role in wound response and tissue homoeostasis.
Rowley et al., Houston, United States. In Biochem Soc Trans, 2011
The present evaluates the key features of the WFDC1 [WAP (whey acidic protein) four disulfide core 1] gene that encodes ps20 (20 kDa prostate stromal protein), a member of the WAP family.
WFDC1 expression identifies memory CD4 T-lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions.
Vyakarnam et al., London, United Kingdom. In Retrovirology, 2010
HIV-1 virus transfer among primary CD4+ T-lymphocytes was promoted by ectopic ps20 expression or by exogenous addition of recombinant ps20.
A mutation of the WFDC1 gene is responsible for multiple ocular defects in cattle.
Kunieda et al., Okayama, Japan. In Genomics, 2009
refined the localization of the MOD locus to a 1.0-Mb interval by haplotype analysis, and found a one-nucleotide insertion in the WFDC1 gene, which resulted in a frame shift mutation and premature termination codon, causing Multiple ocular defects
Modulated expression of WFDC1 during carcinogenesis and cellular senescence.
Rotter et al., Israel. In Carcinogenesis, 2009
our data suggest an important role for WFDC1 in inhibiting proliferation of both tumors and senescent cells
Expression and functional analysis of the WAP four disulfide core domain 1 gene in human melanoma.
Riker et al., Boston, United States. In Clin Exp Metastasis, 2008
suggests that the tumor suppressive function of WFDC1 may be partially a result of up-regulated Dkk1 gene expression, which is known to be a potent inhibitor of the Wnt signaling pathway
Novel innate immune functions of the whey acidic protein family.
Vyakarnam et al., Sheffield, United Kingdom. In Trends Immunol, 2008
Studies on the interaction of HIV with host factors have recently highlighted a potential role in the pathogenesis of AIDS for three distinct members of the whey acidic protein (WAP) family, secretory leukocyte protease inhibitor, Elafin, and ps20.
Proteins with whey-acidic-protein motifs and cancer.
Tremblay et al., Québec, Canada. In Lancet Oncol, 2006
Most notably, the genes coding for elafin, antileukoproteinase 1 (previously called secretory leucocyte proteinase inhibitor, SLPI), WAP four disulphide core domain protein 1 (previously called prostate stromal protein 20 kDa, PS20), and WAP four disulphide core domain protein 2 (previously called major human epididymis-specific protein E4, HE4), have been identified as candidate molecular markers for several cancers.
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas.
Eng et al., Columbus, United States. In Nat Genet, 2002
In contrast, mutations in WFDC1 (16q24, encoding WAP four-disulfide core domain 1) occur with low frequency in the stroma.
Analysis of a chimeric class-I patatin-GUS gene in transgenic potato plants: High-level expression in tubers and sucrose-inducible expression in cultured leaf and stem explants.
Park et al., College Station, United States. In Plant Mol Biol, 1989
To examine the regulation of the patatin genes, we constructed a chimeric gene containing 2.5 kb of 5' flanking sequence from the class I patatin genomic clone PS20 transcriptionally fused to β-glucuronidase (GUS) and introduced it into potato plants using an Agrobacterium tumefaciens Tiplasmid vector.
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