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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

PRT1 Prt1p

PRT1, eIF3b, Prt1p
Contains two ring finger domains and one ZZ domain. Week similarity to yeast Rad18p. Putative component of the N-end rule pathway (ubiquitin-dependent proteolysis). (from NCBI)
Top mentioned proteins: CAN, 110-kDa, HAD, ACID, eIF3j
Papers on PRT1
Biological insights into the expression of translation initiation factors from recombinant CHOK1SV cell lines and their relationship to enhanced productivity.
Smales et al., Andover, United States. In Biochem J, Jan 2016
We have determined mRNA and protein levels of the key components of the closed loop, eIFs (eIF3a, eIF3b, eIF3c, eIF3h, eIF3i and eIF4G1), poly(A)-binding protein (PABP) 1 and PABP-interacting protein 1 (PAIP1), across a panel of 30 recombinant mAb-producing GS-CHOK1SV cell lines with a broad range of growth characteristics and production levels of a model recombinant mAb.
Adaptation to High Ethanol Reveals Complex Evolutionary Pathways.
Verstrepen et al., Leuven, Belgium. In Plos Genet, Nov 2015
Measuring the fitness effects of selected mutations introduced in non-evolved ethanol-sensitive cells revealed several adaptive mutations that had previously not been implicated in ethanol tolerance, including mutations in PRT1, VPS70 and MEX67.
Amino-ether macrocycle that forms CuII templated threaded heteroleptic complexes: a detailed selectivity, structural and theoretical investigations.
Ghosh et al., Calcutta, India. In Dalton Trans, Oct 2015
Further, the double level selectivity studies of MC using different metal ions [CoII, NiII, CuII, ZnII] and a number of simple bidentate chelating ligands shows the selective formation of PRT1 that justifies the self-sorting nature of the system.
Cellular Proteins Act as Bridge Between 5' and 3' Ends of the Coxsackievirus B3 Mediating Genome Circularization During RNA Translation.
Gharbi et al., Tunisia. In Curr Microbiol, Sep 2015
Competitive UV crosslinking assays using BHK-21 cell extract showed common cellular proteins eIF3b, PTB, and La binding to both 5'- and 3' end RNAs.
Screening and analysis on the protein interaction of the protein VP7 in grass carp reovirus.
Jian et al., Zhanjiang, China. In Virus Genes, Jun 2015
By yeast two-hybrid system, after multiple screening with the high screening rate medium, rotary verification, sequencing and bioinformatics analysis, the interactions of the protein VP7 with ribosomal protein S20 (RPS20) and eukaryotic translation initiation factor 3 subunit b (eIF3b) in CIK cells were identified.
In vitro-reduced translation efficiency of coxsackievirus B3 Sabin3-like strain is correlated to impaired binding of cellular initiation factors to viral IRES RNA.
Gharbi et al., Monastir, Tunisia. In Curr Microbiol, May 2015
In the present study, we analyzed, in vitro, the effect of the Sabin3-like mutation on the binding affinity of RNA domain V to some standard translation initiation factors: eIF4G, eIF3b, and eIF4B by filter-binding assays and UV-crosslink assays.
Structure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex.
Ban et al., Zürich, Switzerland. In Nat Struct Mol Biol, Mar 2015
We have resolved a budding yeast initiation complex by cryo-EM, allowing placement of prior structures of eIF1, eIF1A, eIF3a, eIF3b and eIF3c.
Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).
Schuger et al., Baltimore, United States. In J Biol Chem, 2015
Immunoprecipitation coupled with mass spectroscopy identified eIF3 subunit b (eIF3b) as a novel P311 binding partner.
Translation initiation factor eIF3b contains a nine-bladed β-propeller and interacts with the 40S ribosomal subunit.
Ficner et al., Göttingen, Germany. In Structure, 2014
The multisubunit eukaryotic translation initiation factor 3, among which the subunit b (eIF3b) is a major scaffold protein, plays essential roles in protein synthesis.
The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.
Smales et al., Davis, United States. In Biochem J, 2014
In the present study, we show that the eukaryotic cytosolic chaperonin CCT [chaperonin containing TCP-1 (tailless complex polypeptide 1)] binds to newly synthesized eIF3b and promotes the correct folding of eIF3h and eIF3i.
The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis.
de Melo Neto et al., Recife, Brazil. In Bmc Genomics, 2013
Only three subunits were found in all eukaryotes investigated, eIF3b, eIF3c and eIF3i.
Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex.
Zhang et al., Indianapolis, United States. In J Biol Chem, 2013
A subcomplex consisting of eIF3a, eIF3b, eIF3g, and eIF3i (eIF3(a:b:i:g)) has also been identified.
Translation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonization.
Theodorescu et al., Aurora, United States. In Clin Cancer Res, 2013
PURPOSE: Discovery transcriptomic analyses suggest eukaryotic initiation factor 3b (eIF3b) is elevated in human bladder and prostate cancer, yet its role as a prognostic factor or its requirement in the maintenance or progression of human cancer is not established.
Impaired binding of standard initiation factors eIF3b, eIF4G and eIF4B to domain V of the live-attenuated coxsackievirus B3 Sabin3-like IRES--alternatives for 5'UTR-related cardiovirulence mechanisms.
Ben M'hadheb-Gharbi et al., Monastir, Tunisia. In Diagn Pathol, 2012
This procedure allowed the identification of three RNA-binding proteins interacting with the domain V: eIF4G (p220), eIF3b (p116) and eIF4B (p80).
The DEAD-box protein Dhh1 promotes decapping by slowing ribosome movement.
Coller et al., Cleveland, United States. In Plos Biol, 2011
First, we establish that Dhh1 represses translation independent of initiation factors eIF4E and eIF3b.
The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.
Hinnebusch et al., Bethesda, United States. In Mol Cell Biol, 2010
Data suggest that the eIF3b-eIF3j/eIF3a module binds near the mRNA entry channel and regulates the transition between scanning-conducive and initiation-competent conformations of the preinitiation complex.
The indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selection.
Valásek et al., Cambridge, United Kingdom. In J Mol Biol, 2010
a conserved tryptophan residue in the human eIF3j N-terminal acidic motif (NTA) is held in the helix alpha1 and loop 5 hydrophobic pocket of the human eIF3b RNA recognition motif (RRM)
Crystal structure of the RNA recognition motif of yeast translation initiation factor eIF3b reveals differences to human eIF3b.
Ficner et al., Göttingen, Germany. In Plos One, 2009
Yeast eIF3b exhibits RNA binding activity but huamn eIF3b doesn't.
Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit.
Lukavsky et al., Cambridge, United Kingdom. In J Biol Chem, 2007
structural analysis of the eIF3b RNA recognition motif and its interaction with eIF3j
Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast.
Hinnebusch et al., Bethesda, United States. In Mol Cell Biol, 2006
Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eIF3.
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