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Phosphoribosyl pyrophosphate synthetase 2

PRPS2, PRS II, phosphoribosyl pyrophosphate synthetase 2
This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: ACID, PAP39, HAD, V1a, OUT
Papers on PRPS2
PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.
Mao et al., Shenzhen, China. In J Urol, Nov 2015
PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome.
Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus.
Yang et al., Hefei, China. In Hum Mol Genet, 2015
We identified a novel variant in PRPS2 on Xp22.3 as associated with SLE with genome-wide significance (rs7062536, OR = 0.84, P = 1.00E-08).
Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase.
Kashina et al., Philadelphia, United States. In Nat Commun, 2014
We show that the purine nucleotide biosynthesis enzyme PRPS2 is selectively arginylated, unlike its close homologue PRPS1, and that arginylation of PRPS2 directly facilitates its biological activity.
Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.
Minchenko et al., In Ukr Biochem J, 2014
It was shown that hypoxia decreases the expression of PRPS1 and PRPS2 genes in both types of glioma cells, being more pronounced in cells without ERN1 function, but PRPSAP1 and PRPSAP2 gene expressions are suppressed by hypoxia only in glioma cells with blockade of ERN1.
Proteomic analysis on infantile spasm and prenatal stress.
Zou et al., Beijing, China. In Epilepsy Res, 2014
In the NS-spasm model vs. saline control, the main differentially expressed proteins were CFL1, PKM2, PRPS2, DLAT, CKB, DPYSL3, and SNAP25.
Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.
Ruggero et al., San Francisco, United States. In Cell, 2014
We find that a single rate-limiting enzyme, phosphoribosyl-pyrophosphate synthetase 2 (PRPS2), promotes increased nucleotide biosynthesis in Myc-transformed cells.
MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia.
den Boer et al., Rotterdam, Netherlands. In Leuk Res, 2013
Co-expression of these miRNAs resulted in downregulation of DNTT, NUCKS1, MALAT1, SNRPE, PNO1, SET, KIF5B, PRPS2, RPS11, RPL38 and RPL23A (fold-change 1.3-1.9,
HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer.
Winter et al., Philadelphia, United States. In Rna Biol, 2013
Three (GPI, PRPS2 and IDH1) were selected for validation studies, and confirmed as bona fide HuR targets.
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
Nikiforov et al., Buffalo, United States. In Cell Cycle, 2008
Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets.
[Increased activity of PRPP synthetase].
Iizasa, In Nihon Rinsho, 2008
increased activity of this gene leads to gout
Molecular design of photosynthesis-elevated chloroplasts for mass accumulation of a foreign protein.
Shigeoka et al., Nara, Japan. In Plant Cell Physiol, 2008
Analyses of the photosynthetic parameters and the metabolites of transformants into which FBP/SBPase was introduced with various types of promoter (PpsbA, Prrn, Prps2 and Prps12) indicated that a 2- to 3-fold increase in levels of FBPase and SBPase activity is sufficient to increase the final amount of dry matter by up to 1.8-fold relative to the wild-type plants.
Transcriptional targets of hepatocyte growth factor signaling and Ki-ras oncogene activation in colorectal cancer.
Tsao et al., Toronto, Canada. In Oncogene, 2006
Novel proteins identified included histone acetyltransferase 1, phosphoribosyl pyrophosphate synthetase 2, chaperonin containing TCP1, subunit 8, CSE1 chromosome segregation 1-like (yeast)/cellular apoptosis susceptibility (mammals), CCR4-NOT transcription complex, subunit 8, and cyclin H. Transcript levels for these Met-signaling targets were correlated with Met expression levels, and were significantly elevated in both primary and metastatic human colorectal cancer samples compared to normal colorectal mucosa.
Accelerated transcription of PRPS1 in X-linked overactivity of normal human phosphoribosylpyrophosphate synthetase.
Becker et al., Chicago, United States. In J Biol Chem, 1999
Neither PRPS1 amplification nor altered stability or processing of PRS1 mRNA was identified, but PRPS1 transcription was increased relative to GAPDH (3- to 4-fold normal in fibroblasts; 1.9- to 2.4-fold in lymphoblasts) and PRPS2.
Rat liver phosphoribosylpyrophosphate synthetase is activated by free Mg2+ in a manner that overcomes its inhibition by nucleotides.
Tatibana et al., Chiba, Japan. In Biochim Biophys Acta, 1998
The rat liver enzyme is a complex aggregate of two highly homologous catalytic subunits (PRS I and PRS II) and two associated proteins (PAP39 and PAP41).
Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein.
Itakura et al., Tokushima, Japan. In Biochim Biophys Acta, 1998
identity with human PAP39, PRS I, and PRS II, respectively, but lacks the PRPP binding site.
Mammalian phosphoribosyl-pyrophosphate synthetase.
Ahmad et al., Chiba, Japan. In Adv Enzyme Regul, 1994
Cloning of cDNA for the catalytic subunit revealed the presence of two highly homologous isoforms of 34 kDa, designated as PRS I and PRS II.
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