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PRP9 Prp9p

PRP9, SF3a60, Prp9p
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: PRP11, PRP21, PrP, CAN, ACID
Papers on PRP9
Proteins associated with SF3a60 in T. brucei.
Levin et al., Buenos Aires, Argentina. In Plos One, 2013
In this study, we have characterized the trypanosome Splicing Factor, SF3a60, the only currently annotated SF3a component.
Interaction domains and nuclear targeting signals in subunits of the U2 small nuclear ribonucleoprotein particle-associated splicing factor SF3a.
Krämer et al., Genève, Switzerland. In J Biol Chem, 2011
Moreover, an ∼100-amino acid region, including the SURP2 domain of SF3a120 but extending into neighboring regions, is sufficient for binding to SF3a60.
Spp382p interacts with multiple yeast splicing factors, including possible regulators of Prp43 DExD/H-Box protein function.
Rymond et al., Lexington, United States. In Genetics, 2009
Identified, among others, are genes encoding the established splicing factors Prp8p, Prp9p, Prp11p, Prp39p, and Yhc1p and two poorly characterized proteins with possible links to splicing, Sqs1p and Cwc23p.
CLO/GFA1 and ATO are novel regulators of gametic cell fate in plants.
Gross-Hardt et al., Tübingen, Germany. In Plant J, 2008
Furthermore, we demonstrate that ATO encodes the Arabidopsis homologue of SF3a60, a protein that has been implicated in pre-spliceosome formation.
Specific inhibition of transcriptional activity of the constitutive androstane receptor (CAR) by the splicing factor SF3a3.
Seol et al., Pusan, South Korea. In Biol Chem, 2008
SF3a3 functions as a co-repressor of Constitutive Androstane Receptor transcriptional activity, in addition to its canonical function.
Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP.
Yokoyama et al., Yokohama, Japan. In Structure, 2006
The SF3a complex, consisting of SF3a60, SF3a66, and SF3a120, in 17S U2 snRNP is crucial to spliceosomal assembly.
Discovery of eight novel divergent homologs expressed in cattle placenta.
Lewin et al., Urbana, United States. In Physiol Genomics, 2006
These were named as follows: cattle cerebrum and skeletal muscle-specific transcript 1 (CSSMST1), cattle intestine-specific transcript 1 (CIST1), hepatitis A virus cellular receptor 1 amino-terminal domain-containing protein (HAVCRNDP), prolactin-related proteins 8, 9, and 11 (PRP8, PRP9, and PRP11, respectively) and secreted and transmembrane protein 1A and 1B (SECTM1A and SECTM1B, respectively).
U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes.
Lührmann et al., Göttingen, Germany. In Mol Cell Biol, 2006
Contacts between the U2 snRNA and SF3a60, SF3b49, SF3b14a/p14 and SmG and SmB were detected.
Structure-function analysis of the U2 snRNP-associated splicing factor SF3a.
Tanackovic et al., Genève, Switzerland. In Biochem Soc Trans, 2005
Studies aimed at the identification of regions in SF3a60 and SF3a66, required for proper intracellular localization, have led to a model for the final steps in U2 snRNP biogenesis and the proposal that SF3a is incorporated into the U2 snRNP in Cajal bodies.
Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo.
Krämer et al., Genève, Switzerland. In Mol Biol Cell, 2005
SF3a60, 66, and 120, but not SF1, are essential for pre-mRNA splicing
Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing.
Séraphin et al., Gif-sur-Yvette, France. In Embo J, 2005
While SF3a purification revealed only the expected subunits Prp9p, Prp11p and Prp21p, yeast SF3b was found to contain only six subunits, including previously known components (Rse1p, Hsh155p, Cus1p, Hsh49p), the recently identified Rds3p factor and a new small essential protein (Ysf3p) encoded by an unpredicted split ORF in the yeast genome.
A role for Cajal bodies in the final steps of U2 snRNP biogenesis.
Krämer et al., Genève, Switzerland. In J Cell Sci, 2004
To analyze cellular aspects of this process, we studied domains in SF3a60 and SF3a66 that are required for their localization to nuclear speckles.
The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein.
Miki et al., Tokyo, Japan. In Biochem J, 2004
This complex consists of three subunits: SF3a60, SF3a66 and SF3a120.
Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.
Oshimura et al., Hong Kong, Hong Kong. In Biochem Biophys Res Commun, 2004
Defective neuronal differentiation in the presence of extra hChr21 manifested primarily the post-transcriptional and translational modification, such as Mrpl10, SNAPC3, Srprb, SF3a60 in the early neuronal stem cell stage, and Mrps18a, Eef1g, and Ubce8 in the late differentiated stage.
Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation.
Krämer et al., Genève, Switzerland. In Mol Cell Biol, 2001
We have analyzed the function of individual subunits of human SF3a (SF3a60, SF3a66, and SF3a120) by testing recombinant proteins, expressed in insect cells, in various in vitro assays.
Interaction between PRP11 and SPP91 yeast splicing factors and characterization of a PRP9-PRP11-SPP91 complex.
Chapon et al., Paris, France. In Science, 1993
Protein-protein interactions have been identified between two Saccharomyces cerevisiae yeast splicing factors, PRP9 and SPP91.
Interaction of mammalian splicing factor SF3a with U2 snRNP and relation of its 60-kD subunit to yeast PRP9.
Krämer et al., Genève, Switzerland. In Science, 1993
Furthermore, the 60-kilodalton subunit of SF3a is related to the yeast splicing protein PRP9.
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