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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Prospero-related homeobox 1

Top mentioned proteins: vascular endothelial growth factor, PCL, CAN, LYVE-1, KDR
Papers using Prox1 antibodies
Intussusceptive angiogenesis: its emergence, its characteristics, and its significance.
Laudet Vincent, In PLoS ONE, 2003
... Lymphatic endothelial cells were identified using a rabbit anti-Prox-1 antibody (ab11941, 1∶500, Abcam, Paris, France) and pericytes ...
VEGF receptor signal transduction.
Kume Tsutomu, In PLoS ONE, 2000
... 473, Cell Signaling #9271S); rabbit anti-Akt (Cell Signaling #9272); rabbit anti-LYVE-1 (abcam ab14917); and rabbit anti-Prox1 (abcam ab38692) ...
Papers on Prox1
Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction.
Mizuguchi et al., Ōsaka, Japan. In Biochem Biophys Res Commun, Feb 2016
Because the gene expression levels of the hepatic transcription factors (activating transcription factor 5 (ATF5), CCAAT/enhancer-binding protein alpha (c/EBPα), and prospero homeobox protein 1 (PROX1)) in adult liver were significantly higher than those in human iPS-HLCs and fetal liver, we expected that the hepatic functions of human iPS-HLCs could be enhanced by adenovirus (Ad) vector-mediated ATF5, c/EBPα, and PROX1 transduction.
PROX1 promotes secretory granule formation in medullary thyroid cancer cells.
Kamma et al., Kami-renjaku, Japan. In Endocrinology, Feb 2016
Here, we directly demonstrated that PROX1, a developmental homeobox gene, is transcriptionally involved in SG formation in MTC, which is derived from C cells.
Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis.
Joo et al., Kwangju, South Korea. In Gastric Cancer, Feb 2016
BACKGROUND: Prospero homeobox 1 (PROX1) functions as a tumor suppressor gene or an oncogene in various cancer types.
Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line.
Forrest et al., Yokohama, Japan. In Front Genet, 2014
The data confirm NEUROD1 as a key positive regulator in the transcriptional regulatory network (TRN), and ISL1, and PROX1 as antagonists.
Prox1 Inhibits Proliferation and Is Required for Differentiation of the Oligodendrocyte Cell Lineage in the Mouse.
Hidalgo et al., Birmingham, United Kingdom. In Plos One, 2014
Here, we asked whether the mammalian homologue of prospero, Prox1, is involved.
SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.
Schoonjans et al., Lausanne, Switzerland. In Cell Metab, 2014
The mechanism underlying this atheroprotection involves an increase in RCT and its associated hepatic genes and is secondary to a compromised interaction of LRH-1 K289R with the corepressor prospero homeobox protein 1 (PROX1).
Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming.
Deng et al., Beijing, China. In Cell Stem Cell, 2014
Here, we show that functional human induced hepatocytes (hiHeps) can be generated from fibroblasts by overexpressing the hepatic fate conversion factors HNF1A, HNF4A, and HNF6 along with the maturation factors ATF5, PROX1, and CEBPA.
Cellular origin of Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus-induced cell reprogramming.
Boshoff et al., London, United Kingdom. In Trends Cell Biol, 2013
We focus on recent insights into KSHV's ability to exploit the normal differentiation pathway and intrinsic plasticity of ECs, through manipulation of EC-specific transcriptional regulators [i.e., prospero homeobox 1 (PROX1) and MAF] and discuss how this may contribute to viral persistence and KS sarcomagenesis.
Transcription factor PROX1: its role in development and cancer.
Nistér et al., Stockholm, Sweden. In Cancer Metastasis Rev, 2012
The homeobox gene PROX1 is critical for organ development during embryogenesis.
Initial afferent lymphatic vessels controlling outbound leukocyte traffic from skin to lymph nodes.
Melero et al., Pamplona, Spain. In Front Immunol, 2012
Tissue drains fluid and macromolecules through lymphatic vessels (LVs), which are lined by a specialized endothelium that expresses peculiar differentiation proteins, not found in blood vessels (i.e., LYVE-1, Podoplanin, PROX-1, and VEGFR-3).
An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells.
Miller et al., Toronto, Canada. In Cell Stem Cell, 2012
We show that the RNA-binding protein Staufen2 (Stau2) is apically localized in radial glial precursors of the embryonic cortex, where it forms a complex with other RNA granule proteins including Pumilio2 (Pum2) and DDX1, and the mRNAs for β-actin and mammalian prospero, prox1.
Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus.
Matsuzaki et al., Kōbe, Japan. In Development, 2012
Postmitotic elimination of Prox1 caused immature dentate gyrus neurons to lose the granule cell identity and in turn terminally differentiate into the pyramidal cell type manifesting CA3 neuronal identity.
Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.
Riley et al., London, United Kingdom. In Circ Res, 2012
Prox1 is a direct upstream modifier of Nkx2.5 by maintaining the adult conduction system and rescue of Nkx2.5 conduction disease phenotypes.
Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation.
West-Mays et al., Hamilton, Canada. In Invest Ophthalmol Vis Sci, 2012
inappropriate expression of the fiber cell markers c-maf and Prox1 also occurred, indicating a failure of appropriate lens fiber cell differentiation accompanied by altered lens cell proliferation and cell death.
Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus.
Hong et al., Los Angeles, United States. In Plos Pathog, 2011
we report that IL3 receptor alpha (IL3Ralpha) and NOTCH play integral roles in the host cell type-specific regulation of PROX1 by Kaposi sarcoma herpes virus
Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.
Diabetes Prevention Program Research Group et al., Boston, United States. In Plos One, 2011
The only nominal association with diabetes incidence was found for the glucose-lowering allele at PROX1 (P = 0.02), in a direction opposite to that reported in case-control analyses in MAGIC.
Roles for MSI2 and PROX1 in hematopoietic stem cell activity.
Sauvageau et al., Montréal, Canada. In Curr Opin Hematol, 2011
PURPOSE OF REVIEW: The MSI2 and PROX1 proteins are increasingly recognized for their critical roles in the biology of primitive hematopoietic cells and for their potential contributions to leukemic pathogenesis.
Histopathology of vascular anomalies.
Kozakewich et al., Cincinnati, United States. In Clin Plast Surg, 2011
Technical advances such as immunohistochemical stains for GLUT1, an excellent marker for infantile hemangioma, and vascular immunostains such as D2-40, PROX1, and vascular endothelial growth factor receptor 3, which distinguish lymphatics from arteries and veins, have been of immense help in daily practice.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Barroso et al., Boston, United States. In Nat Genet, 2010
These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1).
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
Alitalo et al., Helsinki, Finland. In Cancer Cell, 2008
In intestinal tumors PROX1 is a direct and dose-dependent target of the beta-catenin/TCF signaling pathway, responsible for the neoplastic transformation.
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