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Protein kinase C, epsilon

Protein Kinase C-epsilon, PKCepsilon
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, Protein Kinase C-alpha, CAN, HAD, Protein Kinase C-delta
Papers on Protein Kinase C-epsilon
Cocaine craving during protracted withdrawal requires PKCε priming within vmPFC.
Szumlinski et al., Santa Barbara, United States. In Addict Biol, Feb 2016
As the molecular bases for cocaine-related vmPFC deregulation remain elusive, the present study assayed the consequences of extended access to intravenous cocaine (6 hours/day; 0.25 mg/infusion for 10 day) on the activational state of protein kinase C epsilon (PKCε), an enzyme highly implicated in drug-induced neuroplasticity.
Effect of maturation on the resistance of rat hearts against ischemia. Study of potential molecular mechanisms.
Ravingerová et al., Bratislava, Slovakia. In Physiol Res, Jan 2016
In parallel groups, LV tissue was sampled for the detection of protein levels (WB) of Akt kinase (an effector of PI3-kinase), phosphorylated (activated) Akt (p-Akt), its target endothelial NO synthase (eNOS) and protein kinase Cepsilon (PKCepsilon) as components of "pro-survival" cascades.
The effects of acute ethanol administration on ethanol withdrawal-induced anxiety-like syndrome in rats: A biochemical study.
Ismail et al., Kuala Lumpur, Malaysia. In Alcohol, Dec 2015
This study explores the changes in mGlu5 and PKC epsilon in the amygdala following acute administration of ethanol during ethanol withdrawal (EW) induced anxiety.
The role of microRNAs in the idiopathic inflammatory myopathies.
Lamb et al., Manchester, United Kingdom. In Curr Opin Rheumatol, Nov 2015
For example, higher levels of cytokines appear to inhibit myogenic miRNAs in muscle and artificially reducing levels of miR-223 increases protein kinase C-epsilon (PKCε) levels in keratinocytes.
Gorbunov et al., In Ross Fiziol Zh Im I M Sechenova, Apr 2015
Protein kinase Cepsilon (PKCepsilon) is a target for reactive oxygen species (ROS).
Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes.
Wang et al., T'ai-chung-shih, Taiwan. In Plos One, 2014
Further, cellular levels of protein kinase C epsilon type (PKC-ε) and kinesin heavy chain (KIF5B) increased with time of induction, whereas the level of NME/NM23 nucleoside diphosphate kinase 1 (Nm23-H1) decreased during the time course of differentiation.
Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells.
Asumendi et al., Leioa, Spain. In Leuk Res Treatment, 2014
In all sensitive cells, metformin decreased the Δψ m and it modified the expression of enzymes involved in energy metabolism: PKCε (PKCepsilon) and PKCδ (PKCdelta).
Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler.
Shulman et al., New Haven, United States. In Cell Metab, 2013
The reversal of liver and muscle insulin resistance was associated with reductions in tissue diacylglycerol content and reductions in protein kinase C epsilon (PKCε) and PKCθ activity in liver and muscle, respectively.
Glucocorticoid receptor activation inhibits p53-induced apoptosis of MCF10Amyc cells via induction of protein kinase Cε.
Maki et al., Chicago, United States. In J Biol Chem, 2012
activated GR can inhibit p53-dependent apoptosis through induction of the anti-apoptotic factor PKCepsilon.
Protein kinase C isoforms have differential roles in the regulation of human sebocyte biology.
Bíró et al., Debrecen, Hungary. In J Invest Dermatol, 2012
SZ95 sebocytes express the conventional cPKCalpha; the novel nPKCdelta, epsilon, and eta; and the atypical aPKCzeta
PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus.
Murata et al., Tokyo, Japan. In Biochim Biophys Acta, 2012
These results suggest that PKCdelta and epsilon specifically regulate the morphology of the endoplasmic reticulum-Golgi intermediate compartment.
PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice.
Messing et al., United States. In J Clin Invest, 2012
PKCepsilon-mediated phosphorylation at S142 increased NaV1.8 currents, lowered the threshold voltage for activation, & produced a depolarizing shift in inactivation in wild-type - but not in PKCepsilon-null - sensory neurons.
Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon.
Kazanietz et al., Philadelphia, United States. In Plos One, 2011
Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon
PKC-delta and PKC-epsilon: foes of the same family or strangers?
Crozatier et al., Nantes, France. In J Mol Cell Cardiol, 2011
Protein kinase C (PKC) is a family of 10 serine/threonine kinases divided into 3 subfamilies, classical, novel and atypical classes.
Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.
Harris et al., Austin, United States. In Alcohol Clin Exp Res, 2011
We review such insights for several diverse classes of proteins including inwardly rectifying potassium, transient receptor potential, and neurotransmitter-gated ion channels, as well as protein kinase C epsilon.
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases.
Tian et al., Guangzhou, China. In Front Med, 2011
Protein kinase C epsilon (PKC ɛ) is one of major isoforms in novel PKC family.
A negative regulatory pathway of GLUT4 trafficking in adipocyte: new function of RIP140 in the cytoplasm via AS160.
Wei et al., Minneapolis, United States. In Cell Metab, 2009
In adipocytes, RIP140 can be phosphorylated by protein kinase C epsilon (PKCvarepsilon), followed by arginine methylation, and exported to the cytoplasm.
The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis.
Parker et al., London, United Kingdom. In Nat Cell Biol, 2008
Specifically, we have identified three phosphorylation sites within PKCepsilon that control its association with 14-3-3.
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Yamada et al., Tsukuba, Japan. In Nat Med, 2007
Amelioration of insulin resistance was associated with restoration of hepatic insulin receptor substrate-2 and suppression of hepatic protein kinase C epsilon activity resulting in restoration of Akt phosphorylation.
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.
Biden et al., Sydney, Australia. In Cell Metab, 2007
These findings implicate PKCepsilon in the etiology of beta cell dysfunction and highlight that enhancement of insulin availability provides a rationale for inhibiting PKCepsilon to treat type 2 diabetes.
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