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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein kinase C, delta

Protein Kinase C-delta, PKCdelta
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, Protein Kinase C-alpha, CAN, PrP, HAD
Papers on Protein Kinase C-delta
Protein kinase Cδ regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14-3-3ζ.
Ullrich et al., Tübingen, Germany. In Diabetologia, Dec 2015
Since our previous observations suggest that protein kinase C delta (PKCδ) induces nuclear accumulation of FOXO1, the underlying mechanism was examined.
Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK.
Kim et al., South Korea. In J Neuroinflammation, Dec 2015
METHODS: We examined changes in mitogen-activated protein kinases (MAPKs), mitochondrial function [i.e., mitochondrial membrane potential, intramitochondrial Ca(2+) accumulation, mitochondrial oxidative burdens, mitochondrial superoxide dismutase expression, and mitochondrial translocation of the cleaved form of protein kinase C delta type (cleaved PKCδ)], microglial activity, and pro-apoptotic changes [i.e., cytosolic cytochrome c release, cleaved caspase 3, and terminal deoxynucleotidyl transferase dUDP nick-end labeling (TUNEL) positive populations] after a neurotoxic dose of MA in the striatum of mice to achieve a better understanding of the effects of apocynin, a non-specific PHOX inhibitor, or genetic inhibition of p47phox (by using p47phox knockout mice or p47phox antisense oligonucleotide) against MA-induced dopaminergic neurotoxicity.
Essential Nonredundant Function of the Catalytic Activity of Histone Deacetylase 2 in Mouse Development.
Seiser et al., Vienna, Austria. In Mol Cell Biol, 2014
They display changes in brain architecture accompanied by premature expression of the key regulator protein kinase C delta.
Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells.
Asumendi et al., Leioa, Spain. In Leuk Res Treatment, 2014
In all sensitive cells, metformin decreased the Δψ m and it modified the expression of enzymes involved in energy metabolism: PKCε (PKCepsilon) and PKCδ (PKCdelta).
MiR181c inhibits ovarian cancer metastasis and progression by targeting PRKCD expression.
Liu et al., Binzhou, China. In Int J Clin Exp Med, 2014
Through bioinformatics prediction, protein kinase C delta (PRKCD) was identified as a target gene of miR-181c.
Protein kinase C isoforms have differential roles in the regulation of human sebocyte biology.
Bíró et al., Debrecen, Hungary. In J Invest Dermatol, 2012
SZ95 sebocytes express the conventional cPKCalpha; the novel nPKCdelta, epsilon, and eta; and the atypical aPKCzeta
Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy.
King et al., Boston, United States. In Faseb J, 2012
Hyperglycemia and diabetes can cause glomerular podocyte apoptosis and endothelial dysfunction partly due to increased PKCdelta/p38 MAPK activation and the expression of SHP-1 to cause VEGF resistance, independent of NF-kappaB activation.
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
Wu et al., New Haven, United States. In Nat Cell Biol, 2012
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.
Protein kinase C-δ negatively regulates T cell receptor-induced NF-κB activation by inhibiting the assembly of CARMA1 signalosome.
Shu et al., Wuhan, China. In J Biol Chem, 2012
PKCdelta is a negative regulator in T cell activation through inhibiting the assembly of CARMA1 signalosome.
Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42.
Liu et al., Madison, United States. In Mol Biol Cell, 2012
PKCdelta mediates collagen I secretion from smooth muscle cells, likely through a Cdc42-dependent mechanism.
In Sjögren's syndrome, B lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase C delta activation.
Pers et al., Brest, France. In Autoimmun Rev, 2012
mediates B lymphocyte-induced aopotosis of epithelial cells in salivary glands of Sjogren's syndrome patients
Interplay between FAK, PKCδ, and p190RhoGAP in the regulation of endothelial barrier function.
Harrington et al., Providence, United States. In Microvasc Res, 2012
In this review, we will discuss the functions of three signaling molecules known to be involved in regulation of endothelial permeability: focal adhesion kinase (FAK), protein kinase C delta (PKCδ), and p190RhoGAP (p190).
Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: relevance to oxidative stress and neuroinflammation in Parkinson's disease.
Rana et al., Ames, United States. In Neurotoxicology, 2010
Dr. Anumantha Kanthasamy described a cell death pathway involving the novel protein kinase C delta isoform (PKCdelta) in oxidative stress-induced apoptotic cell death in experimental models of PD.
Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer.
Ozpolat et al., Austin, United States. In Autophagy, 2010
On the other hand, the induction of autophagy by the inhibition of anti-autophagic proteins, such as Bcl-2, PKCdelta, and tissue transglutaminase 2 (TG2), may lead to autophagic cell death in some apoptosis-resistant cancers (i.e., breast and pancreatic cancers), indicating that the induction of autophagy alone may also be used as a potential therapy.
Cardioprotection by regular ethanol consumption: potential mechanisms and clinical application.
Figueredo et al., Ōsaka, Japan. In Curr Drug Abuse Rev, 2010
Proposed mechanisms of cardioprotection by regular ethanol consumption include activation of adenosine A1 receptors, alpha(1)-adrenoceptors, protein kinase C-delta and epsilon, adenosine triphosphate-dependent potassium (K(ATP)) channels, nitric oxide synthase and reduced leukocyte-endothelial cell adhesive interactions.
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
King et al., Boston, United States. In Nat Med, 2009
hyperglycemia persistently activates protein kinase C-delta and p38alpha mitogen-activated protein kinase to increase the expression of Src homology-2 domain-containing phosphatase-1, a protein tyrosine phosphatase
Protein kinase D is an essential regulator of C. elegans innate immunity.
Rubin et al., United States. In Immunity, 2009
TPA-1, a PKCdelta homolog, regulated activation and functions of DKF-2 in vivo.
Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.
Bishop et al., Iowa City, United States. In Immunity, 2007
Resting splenic B cells from these mice exhibited remarkably prolonged survival ex vivo independent of B cell activating factor and showed increased amounts of active nuclear factor-kappaB2 but decreased amounts of nuclear protein kinase Cdelta.
A semisynthetic epitope for kinase substrates.
Shokat et al., San Francisco, United States. In Nat Methods, 2007
We demonstrated the generality of semisynthetic epitope construction with 13 diverse kinases: JNK1, p38alpha MAPK, Erk1, Erk2, Akt1, PKCdelta, PKCepsilon, Cdk1/cyclinB, CK1, Cdc5, GSK3beta, Src and Abl.
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.
Hara et al., Tokushima, Japan. In Nat Cell Biol, 2006
Here, we show that the p16(INK4a) /Rb-pathway also cooperates with mitogenic signals to induce elevated intracellular levels of reactive oxygen species (ROS), thereby activating protein kinase Cdelta (PKCdelta) in human senescent cells.
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