gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Prostaglandin I2

prostacyclin receptor, PTGIR
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, CAN, cyclooxygenase, HAD
Papers on prostacyclin receptor
Comparative Safety and Tolerability of Prostacyclins in Pulmonary Hypertension.
Sitbon et al., Le Kremlin-Bicêtre, France. In Drug Saf, Feb 2016
Selexipag is the new oral non-prostanoid IP prostacyclin receptor agonist that has shown improved haemodynamics and good tolerance in a phase II study.
Targeted Treatments for Pulmonary Arterial Hypertension: Interpreting Outcomes by Network Meta-analysis.
Messori et al., Florence, Italy. In Heart Lung Circ, Jan 2016
The following five classes of agents indicated for PAH were evaluated: 1) oral endothelin receptor antagonists (ERAs); 2) oral phosphodiesterase type 5 inhibitors (PDE-5Is); 3) prostanoids administered by oral, intravenous, subcutaneous or inhalatory route; 4) selective non-prostanoid prostacyclin receptor (IP receptor) agonists (sPRAs); 5) soluble guanylate cyclase stimulators (sGCSs).
Effects of low level laser therapy on inflammatory and angiogenic gene expression during the process of bone healing: A microarray analysis.
Rennó et al., São Carlos, Brazil. In J Photochem Photobiol B, Jan 2016
Microarray analysis demonstrated that LLLT produced an up-regulation of the genes related to the inflammatory process (MMD, PTGIR, PTGS2, Ptger2, IL1, 1IL6, IL8, IL18) and the angiogenic genes (FGF14, FGF2, ANGPT2, ANGPT4 and PDGFD) at 36h and 3days, followed by the decrease of the gene expression on day 7. Immunohistochemical analysis revealed that the subjects that were treated presented a higher expression of COX-2 at 36h after surgery and an increased VEGF expression on days 3 and 7 after surgery.
Recent advances in targeting the prostacyclin pathway in pulmonary arterial hypertension.
Gaine et al., Vienna, Austria. In Eur Respir Rev, Dec 2015
In patients with PAH, pulmonary concentrations of prostacyclin, a prostanoid that targets several receptors including the IP prostacyclin receptor, are reduced.
Prostacyclin receptor (PTGIR) in the porcine endometrium: Regulation of expression and role in luminal epithelial and stromal cells.
Andronowska et al., Olsztyn, Poland. In Theriogenology, Nov 2015
The present study was designed to examine (1) the expression of PGI2 receptor (PTGIR) messenger RNA (mRNA) and protein in the endometrium of cyclic and early-pregnant gilts; (2) possible regulation of endometrial PTGIR gene expression by conceptus products, estradiol and cytokines; (3) the effect of iloprost (a PGI2 analogue) on cAMP formation and the expression of fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF; isoform 164) mRNA in luminal epithelial (LE) and stromal (ST) cells.
Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
Clozel et al., Kyoto, Japan. In J Med Chem, Oct 2015
Prostacyclin controls cardiovascular function via activation of the prostacyclin receptor.
Bioequivalence of different dose-strength tablets of selexipag, a selective prostacyclin receptor agonist, in a multiple-dose up-titration study.
Dingemanse et al., In Int J Clin Pharmacol Ther, Sep 2015
OBJECTIVE: Selexipag is a novel, oral, selective prostacyclin (PGI2) receptor agonist in clinical development for the treatment of pulmonary arterial hypertension.
Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms.
Kinsella et al., Dublin, Ireland. In Prostaglandins Other Lipid Mediat, Sep 2015
This review details recent advances in understanding the key transcriptional regulators determining expression of the PTGIR gene in the human vasculature and the identification of novel interacting partners of the IP that impact on its function therein.
Mechanism of hydralazine-induced relaxation in resistance arteries during pregnancy: Hydralazine induces vasodilation via a prostacyclin pathway.
Osol et al., United States. In Vascul Pharmacol, Aug 2015
These vasodilatory effects were abolished by: (1) preconstriction with a potassium depolarizing solution, (2) endothelial denudation (for concentrations of hydralazine<10μM), (3) addition of non-selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors, and (4) pretreatment with a prostacyclin receptor antagonist (R01138452).
Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease.
GAPP study in collaboration with the MCMDM-1VWD study group et al., Sheffield, United Kingdom. In Plos One, 2014
Platelet G protein-coupled receptor genes P2RY1, F2R, F2RL3, TBXA2R and PTGIR were sequenced in 146 index cases with type 1 von Willebrand disease and the potential effects of identified single nucleotide variations were assessed using in silico methods and heterologous expression analysis.
Expression of prostaglandin I2 (prostacyclin) receptor in blood of migraine patients: A potential biomarker.
Koulivand et al., Eşfahān, Iran. In Adv Biomed Res, 2014
According to the role of prostaglandin I2 (prostacyclin) receptor (PTGIR) in migraine as a receptor, which acts in vasodilatation, we decided to study the changes of PTGIR expression in migraine patients in relation to a suitable control group.
Existing drugs and agents under investigation for pulmonary arterial hypertension.
Frishman et al., Norwalk, United States. In Cardiol Rev, 2014
These agents include rho-kinase inhibitors, long-acting nonprostanoid prostacyclin receptor agonists, tyrosine protein kinase inhibitors, endothelial nitric oxide synthase couplers, synthetically produced vasoactive intestinal peptide, antagonists of the 5-HT2 receptors, and others.
Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin.
Yamashita et al., Suita, Japan. In Nat Med, 2012
Inhibition of prostacyclin receptor signaling impaired motor recovery, whereas the IP receptor agonist iloprost promoted axonal remodeling and motor recovery after the induction of EAE.
Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP).
Kinsella et al., Dublin, Ireland. In Biochim Biophys Acta, 2012
IKEPP was also found to be expressed in vascular endothelial cells where it co-localizes and complexes with the hIP
Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner.
Hida et al., Sapporo, Japan. In Cancer Sci, 2012
the IP receptor was expressed in blood vessels of renal cell carcinoma specimens, but not in glomerular vessels of normal renal tissue; findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel.
Sprague et al., Saint Louis, United States. In Am J Physiol Heart Circ Physiol, 2012
VDAC is the ATP conduit in the IP receptor-mediated signaling pathway in human erythrocytes.
Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis.
Kinsella et al., Dublin, Ireland. In Mol Biol Cell, 2011
Human prostacyclin receptor interacts with the PDZ adapter protein PDZK1; this interaction plays important role in endothelial cell migration and angiogenesis.
Identification of a novel endoplasmic reticulum export motif within the eighth α-helical domain (α-H8) of the human prostacyclin receptor.
Kinsella et al., Dublin, Ireland. In Biochim Biophys Acta, 2011
study identified a novel 8 residue ER export motif within the functionally important alpha-H8 of the hIP.
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor.
Narumiya et al., Kyoto, Japan. In Nature, 1997
Here we disrupt the gene for the prostacyclin receptor in mice by using homologous recombination.
Cytoprotective Role of Prostaglandin D2 DP1 Receptor against Neuronal Injury Following Acute Excitotoxicity and Cerebral Ischemia
Shafique Ahmad et al., Boca Raton, United States. In Unknown Journal, 0001
These PGs exert their actions through specific high-affinity G protein-coupled receptors named DP1-DP2 (PGD2 receptor 1-PGD2 receptor 2), EP1-EP4 (PGE2 receptor 1-4), FP (PGF2α receptor), IP (PGI2 receptor or prostacyclin receptor), and TP (thromboxane receptor) receptors, respectively.
share on facebooktweetadd +1mail to friends