Cocaine craving during protracted withdrawal requires PKCε priming within vmPFC.
Santa Barbara, United States. In Addict Biol, Feb 2016
This effect was more robust within the ventromedial versus dorsomedial PFC, was not observed in comparable cocaine-experienced rats not tested for drug-seeking behavior and was distinct from the rise in phosphorylated extracellular signal-regulated kinase observed in cocaine-seeking rats.
Can anxiety damage the brain?
Toronto, Canada. In Curr Opin Psychiatry, Jan 2016
RECENT FINDINGS: Anxiety disorders are associated with alterations in fear neurocircuitry such that 'bottom-up' processes in the amygdala which respond to threat are exaggerated, and regulation of these processes by the prefrontal cortex (PFC) and hippocampus is impaired.
Relationships Between Gum-Chewing and Stress.
Tokyo, Japan. In Adv Exp Med Biol, Dec 2015
On the other hand, studies have suggested that the right prefrontal cortex (PFC) dominates the regulation of the stress response system, including the hypothalamic-pituitary-adrenal (HPA) axis.
Précis on The Cognitive-Emotional Brain.
College Park, United States. In Behav Brain Sci, 2015
(2) Cognitive-emotional interactions in the human prefrontal cortex (PFC) assume diverse forms and are not limited to mutual suppression.
The Regulation of Task Performance: A Trans-Disciplinary Review.
Nagoya, Japan. In Front Psychol, 2014
We will rigorously explore research that addresses the pivotal role of the prefrontal cortex (PFC) in controlling the meta-cognitive processes that underpin the self-regulated learning (SRL) strategies learners employ to regulate task performance.
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Stanford, United States. In Nature, 2013
The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of behaviours (including the decision to execute actions); indeed, imaging and lesion studies in human beings have revealed that PFC dysfunction can lead to either impulsive states with increased tendency to initiate action, or to amotivational states characterized by symptoms such as reduced activity, hopelessness and depressed mood.