The brain in bone and fuel metabolism.
Sydney, Australia. In Bone, Jan 2016
Two main neuronal populations within the arcuate nucleus of the hypothalamus regulate energy homeostasis: The orexigenic, appetite-stimulating neurons that co-express neuropeptide Y and agouti-related peptide and the anorexigenic, appetite-suppressing neurons that co-express proopiomelanocortin and cocaine- and amphetamine related transcript.
60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease.
London, United Kingdom. In J Mol Endocrinol, Jan 2016
With this work they instantly confirmed the single precursor hypothesis for ACTH-β-lipotropin, as it was then known, and in so doing revealed the existence of additional, largely unpredicted, N-terminal peptides that together formed the proopiomelanocortin (POMC) precursor peptide.