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Prolactin receptor

prolactin receptor, PRLR, PR1, PRL receptor, PRI
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Prolactin, ACID, HAD, CAN, V1a
Papers using prolactin receptor antibodies
A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation
Barner Ross et al., In Breast Cancer : Basic and Clinical Research, 2003
... antiserum directed against STAT5a (L-20, Santa Cruz Biotechnology Inc, Santa Cruz, CA, diluted 1:100) and anti-PRLR clone SPM213 (Abcam Inc., Cambridge, MA, undiluted).
Papers on prolactin receptor
The innate immune signaling system as a regulator of disease resistance and ISR activity against Verticillium dahliae.
Tjamos et al., Athens, Greece. In Mol Plant Microbe Interact, Feb 2016
The resistance induced by strain K165 is dependent on both salicylate and jasmonate-dependent defense pathways as evidenced by an increased transient accumulation of PR1 and PDF1.2 transcripts in the aerial parts of infected plants treated with strain K165.
Biocontrol potential of Trichoderma harzianum isolate T-aloe against Sclerotinia sclerotiorum in soybean.
Li et al., China. In Plant Physiol Biochem, Feb 2016
The defense-related genes PR1, PR2, and PR3 were expressed in the leaves of T-aloe-treated plants.
Pri sORF peptides induce selective proteasome-mediated protein processing.
Plaza et al., Toulouse, France. In Science, Oct 2015
Here, we show that Drosophila polished-rice (pri) sORF peptides trigger proteasome-mediated protein processing, converting the Shavenbaby (Svb) transcription repressor into a shorter activator.
Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells.
Danilenko et al., Beersheba, Israel. In J Steroid Biochem Mol Biol, Oct 2015
Here we characterized the differentiation-inducing effects of novel double-point modified analogs of 1,25-dihydroxyvitamin D2 [1,25(OH)2D2], PRI-5201 and PRI-5202 [Pietraszek et al. (2013) Steroids, 78:1003-1014], on HL60, U937 and MOLM-13 human AML cells in comparison with their direct precursors (PRI-1906 and PRI-1907, respectively) and 1,25(OH)2D3.
A Biogenesis Step Upstream of Microprocessor Controls miR-17∼92 Expression.
Gregory et al., Boston, United States. In Cell, Sep 2015
Here, we find that the relative expression of the six miRNAs processed from the primary (pri-miR-17∼92) transcript is dynamically regulated during embryonic stem cell (ESC) differentiation.
small ORFs: A new class of essential genes for development.
da Fonseca et al., Macaé, Brazil. In Genet Mol Biol, Jul 2015
Finally, we discuss the biological role of the most studied smORF so far, the Mlpt/Pri/Tal gene in arthropods.
New insights in prolactin: pathological implications.
Binart et al., Le Kremlin-Bicêtre, France. In Nat Rev Endocrinol, May 2015
The major isoform, 23 kDa prolactin, acts via its membrane receptor, the prolactin receptor (PRL-R), which is a member of the haematopoietic cytokine superfamily and for which the mechanism of activation has been deciphered.
Endocrine hormones and local signals during the development of the mouse mammary gland.
Ataca et al., Lausanne, Switzerland. In Wiley Interdiscip Rev Dev Biol, May 2015
While hormones impinge on many tissues and trigger very complex biological responses, tissue recombination experiments with hormone receptor-deficient mammary epithelia revealed eminent roles for estrogens, progesterone, and prolactin receptor (PrlR) signaling that are intrinsic to the mammary epithelium.
Apoplastic Nucleoside Accumulation in Arabidopsis Leads to Reduced Photosynthetic Performance and Increased Susceptibility Against Botrytis cinerea.
Möhlmann et al., Kaiserslautern, Germany. In Front Plant Sci, 2014
Moreover, a higher susceptibility toward Botrytis cinerea infection and a reduced induction of pathogen related genes PR1 and WRKY33 was observed.
The prolactin receptor as a therapeutic target in human diseases: browsing new potential indications.
Touraine et al., Paris, France. In Expert Opin Ther Targets, 2014
This has encouraged various laboratories to develop compounds targeting the PRL receptor (PRLR).
Identification of SNPs within the PRLR gene and effects on maternal behavior in sheep.
Sun et al., Yancheng, China. In Genet Mol Res, 2014
The prolactin receptor gene (PRLR) plays an essential role in maternal behavior.
Pseudomonas fluorescens and Trichoderma asperellum Enhance Expression of Gα Subunits of the Pea Heterotrimeric G-protein during Erysiphe pisi Infection.
Ahmed et al., Benares, India. In Front Plant Sci, 2014
Non-increment of SA content as well as transcripts of SA-dependent PR1 suggested non-activation of the SA-mediated signal transduction in the interaction of pea with E. pisi under the stimuli of OKC and T42.
Pri peptides are mediators of ecdysone for the temporal control of development.
Payre et al., Toulouse, France. In Nat Cell Biol, 2014
Here we show that Pri peptides, encoded by small open reading frames, are direct mediators of the steroid hormone ecdysone for the timing of developmental programs in Drosophila.
Mutant prolactin receptor and familial hyperprolactinemia.
Thakker et al., Glasgow, United Kingdom. In N Engl J Med, 2013
These symptoms were not associated with pituitary tumors or multiple endocrine neoplasia but were due to a heterozygous mutation in the prolactin receptor gene, PRLR, resulting in an amino acid change from histidine to arginine at codon 188 (His188Arg).
Molecular mechanisms of prolactin and its receptor.
Brooks, Columbus, United States. In Endocr Rev, 2012
The prolactin receptor is particularly interesting because it can be activated by three sequence-diverse human hormones: prolactin, GH, and placental lactogen.
Characterization of multiple first exons in murine prolactin receptor gene and the effect of prolactin on their expression in the choroid plexus.
Tanaka et al., Musashino, Japan. In J Mol Endocrinol, 2012
Data suggest that PRL stimulates the Prlr gene expression through the transcriptional activation of mE1(4) first exon, leading to increases in the long- and short-form variants of Prlr mRNA in the murine choroid plexus.
The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor.
Kragelund et al., Copenhagen, Denmark. In Structure, 2012
The structure of the human prolactin receptor reveals a structural link between the WSXWS motif, hormone binding, and receptor dimerization and we propose it as a general mechanism for class 1 receptor activation.
Prolactin receptor antagonism in mouse anterior pituitary: effects on cell turnover and prolactin receptor expression.
Pisera et al., Buenos Aires, Argentina. In Am J Physiol Endocrinol Metab, 2012
Data suggest that prolactin is involved in regulation of prolactin receptor expression and maintenance of physiological cell renewal in anterior pituitary. Prolactin/prolactin receptor signaling may be involved in regulation of pituitary gland size.
Prolactin receptor in primary hyperparathyroidism--expression, functionality and clinical correlations.
Larsson et al., Stockholm, Sweden. In Plos One, 2011
PRLr isoforms expression and PRLr subcellular localisation are altered in parathyroid tumours
PTEN modulates miR-21 processing via RNA-regulatory protein RNH1.
Kim et al., Taejŏn, South Korea. In Plos One, 2010
PTEN-mediated miR-21 regulation is achieved by inhibiting the interaction between the Drosha complex and RNH1, revealing previously unidentified role of PTEN in the oncogenic miR-21 biogenesis
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