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Profilin 1

profilin, profilin I
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, CAN, IgE, HAD, cofilin
Papers using profilin antibodies
Pairwise multiple comparison procedures with unequal n's and/or variances: A Monte Carlo study.
Uversky Vladimir N., In PLoS ONE, 1975
... RT-PCR, Cloning and sequencing of profilin transcriptsTotal RNA was isolated from 100 mg pollen samples of each cultivar/species by using the RNeasy Plant Total RNA kit (Qiagen).
Papers on profilin
Disease Causing mutations in Inverted Formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and Profilin 2.
Welsh et al., Bristol, United Kingdom. In Biosci Rep, Feb 2016
Furthermore using a combination of GFP-INF2 expression in human podocytes and GFP-Trap purification coupled with Mass Spectrometry we demonstrate that INF2 interacts with profilin 2 and the F-actin capping protein, CapZ alpha-1.
Profilin desensitization: A case series.
Schiavino et al., Roma, Italy. In Int J Immunopathol Pharmacol, Jan 2016
UNASSIGNED: The role of profilin as an allergen has long been questioned.
Role of the C-terminal extension of Formin 2 in its activation by Spire and processive assembly of actin filaments.
Carlier et al., France. In J Biol Chem, Jan 2016
This formin cooperates with profilin and Spire, a WH2 repeat protein, to stimulate assembly of a dynamic cytoplasmic actin meshwork that facilitates translocation of the meiotic spindle in asymmetric division of mouse oocytes.
Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation.
Mattson et al., Baltimore, United States. In J Neurosci, Jan 2016
Shh pathway activation results in increased levels of profilin1 (Pfn1), an actin-binding protein.
Molecular characterization and In silico analysis of Sorghum Panallergens: Profilin and Polcalin.
Bondili et al., In Indian J Exp Biol, Nov 2015
Profilin and polcalcin are the known pollen specific panallergens.
RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy.
Zheng et al., Shanghai, China. In Graefes Arch Clin Exp Ophthalmol, May 2015
Increasing evidence suggests that in DR, the small guanosine-5'-triphosphate-binding protein RhoA activates its downstream targets mammalian Diaphanous homolog 1 (mDia-1) and profilin-1, thus affecting important cellular functions, including cell morphology, motility, secretion, proliferation, and gene expression.
Intracellular signaling by cathepsin X: molecular mechanisms and diagnostic and therapeutic opportunities in cancer.
Pišlar et al., Ljubljana, Slovenia. In Semin Cancer Biol, Apr 2015
Several other molecules, involved in cellular signaling, have since been shown to be targets for cathepsin X, such as γ-enolase, chemokine CXCL-12, bradykinin, kallidin, huntingtin and profilin 1.
[Regulation of pollen tube growth by reversible protein phosphorylation].
Dai et al., Harbin, China. In Yi Chuan, 2014
(3) The dynamics of actin polymerization and depolymerization are regulated by reversible phosphorylation of actin binding proteins (e.g., ADF and profilin).
Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.
Fox et al., Cleveland, United States. In Nat Cell Biol, 2014
Phosphorylation of profilin-1 (Pfn-1) at Tyr 129 in ECs induces binding to the tumour suppressor protein von Hippel-Lindau (VHL), and prevents VHL-mediated degradation of prolyl-hydroxylated HIF-1α, culminating in HIF-1α accumulation even in normoxia.
Amaranthaceae pollens: review of an emerging allergy in the mediterranean area.
Rodríguez et al., In J Investig Allergol Clin Immunol, 2013
To date, 9Amaranthaceae pollen allergens from Chenopodium album, Salsola kali, and Amaranthus retroflexus have been described and are listed in the International Union of Immunological Societies allergen nomenclature database.The major allergens ofAmaranthaceae pollen belong to the pectin methylesterase, Ole e 1-like, and profilin panallergen families, whereas the minor allergens belong to the cobalamin- independent methionine synthase and polcalcin panallergen families.
Benefits and limitations of molecular diagnostics in peanut allergy: Part 14 of the series Molecular Allergology.
Kleine-Tebbe et al., Bonn, Germany. In Allergo J Int, 2013
Hazardous sensitization to seed storage proteins [S2 albumins (Ara h 2, 6 and 7) > other seed storage proteins (Ara 1 and 3) > oleosins (Ara h 10 and 11)] are distinct from sensitizations to lipid transfer protein (Ara h 9) with moderate risk or cross-sensitizations to Bet v 1-homologous PR-10 protein (Ara h 8) and to profilin (Ara h 5) with low risk.
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Ghosh et al., New York City, United States. In Immunity, 2013
Toll-like receptor 11 (TLR11) recognizes T. gondii profilin (TgPRF) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii-infected mice.
Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.
Brugge et al., Boston, United States. In Cancer Cell, 2012
Here, we demonstrate that profilin-1 and profilin-2 differentially regulate membrane protrusion, motility, and invasion; these processes are promoted by profilin-1 and suppressed by profilin-2.
Stimulus-dependent phosphorylation of profilin-1 in angiogenesis.
Fox et al., Cleveland, United States. In Nat Cell Biol, 2012
Profilin-1 (Pfn-1) is an actin-binding protein that enhances actin filament formation and cell migration, but stimulus-dependent regulation of Pfn-1 has not been observed.
Profilin phosphorylation as a VEGFR effector in angiogenesis.
Schwartz et al., In Nat Cell Biol, 2012
Direct phosphorylation of the actin-binding protein profilin by VEGF receptors is now shown to increase its affinity for actin, and to be essential for adult but not embryonic arteriogenesis.
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.
Landers et al., Worcester, United States. In Nature, 2012
mutations within the profilin 1 (PFN1) gene can cause familial amyotrophic lateral sclerosis
Poly(I:C) treatment influences the expression of calreticulin and profilin-1 in a human HNSCC cell line: a proteomic study.
Pavelić et al., Zagreb, Croatia. In Tumour Biol, 2012
Data show that calreticulin and profilin-1 are differentially expressed after poly(I:C) treatment, and that calreticulin expression might be Toll-like receptor 3 (TLR3) dependent by using TLR3 small interfering RNA.
Profilin 1 is a potential biomarker for bladder cancer aggressiveness.
Vlahou et al., Athens, Greece. In Mol Cell Proteomics, 2012
By tissue microarray, profilin 1 expression was markedly decreased in epithelial cells of the invasive versus high risk non invasive bladder tumors; this pattern is strongly correlated with poor prognosis and increased mortality
Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells.
Roy et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2011
Data show that profilin1 negatively regulates lamellipodin targeting to the leading edge; profilin1 depletion increases lamellipodin concentration at the lamellipodial tip (where it binds Ena/VASP), and this mediates the hypermotility.
IgE recognition patterns of profilin, PR-10, and tropomyosin panallergens tested in 3,113 allergic patients by allergen microarray-based technology.
Mari et al., Roma, Italy. In Plos One, 2010
IgE recognition profile of profilins, PR-10 proteins and tropomyosin, were evaluated.
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