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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Proenkephalin b

Top mentioned proteins: Enkephalin, ACID, Neuropeptide, CAN, HAD
Papers on proenkephalin
60 YEARS OF POMC: POMC: an evolutionary perspective.
Cerdá-Reverter et al., Spain. In J Mol Endocrinol, Jan 2016
This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodinorphyn (PDYN) and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event.
Effects of footshocks on anxiety-like behavior and mRNA levels of precursor peptides for corticotropin releasing factor and opioids in the forebrain of the rat.
Kirouac et al., Winnipeg, Canada. In Neuropeptides, Dec 2015
In contrast, prodynorphin and proenkephalin mRNA levels in the striatum, BST and CeA were not different between HR, LR and nonshocked rats.
Effects of an opioid (proenkephalin) polymorphism on neural response to errors in health and cocaine use disorder.
Goldstein et al., New York City, United States. In Behav Brain Res, Nov 2015
In the current imaging genetics study, we investigated a single nucleotide polymorphism (SNP) of the protein-coding proenkephalin gene (PENK: rs2609997, recently shown to be associated with cannabis dependence) in 55 individuals with cocaine use disorder and 37 healthy controls.
Molecular Histochemistry Identifies Peptidomic Organization and Reorganization Along Striatal Projection Units.
Hiroi et al., New York City, United States. In Biol Psychiatry, Oct 2015
The spatial expression patterns of substance P and proenkephalin, marker neuropeptides of two distinct striatal projection neurons, were negatively correlated at baseline.
Altered Gene Expression Profile of the Hypothalamic Arcuate Nucleus of Male Mice Suggests Profound Developmental Changes in Peptidergic Signaling.
Hrabovszky et al., Budapest, Hungary. In Neuroendocrinology, Sep 2015
Adult animals showed increased mRNA levels encoding cocaine- and amphetamine-regulated transcript, galanin-like peptide, dynorphin, kisspeptin, proopiomelanocortin, proenkephalin and galanin and reduced expression of mRNAs for pituitary adenylate cyclase activating peptide, calcitonin gene-related peptide, neuropeptide Y, substance P, agouti-related protein, neurotensin and growth hormone-releasing hormone.
Serum Proenkephalin A Levels and Mortality After Long-Term Follow-Up in Patients with Type 2 Diabetes Mellitus (ZODIAC-32).
Kleefstra et al., Zwolle, Netherlands. In Plos One, 2014
BACKGROUND: Two previous studies concluded that proenkephalin A (PENK-A) had predictive capabilities for stroke severity, recurrent myocardial infarction, heart failure and mortality in patients with stroke and myocardial infarction.
Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human.
Hrabovszky et al., Budapest, Hungary. In Front Neurosci, 2014
Similarly, galanin is detectable in mouse, but not human, KP cells, whereas substance P, cocaine- and amphetamine-regulated transcript and proenkephalin-derived opioids are expressed in varying subsets of KP neurons in humans, but not reported in ARC of other species.
Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection.
Melander et al., Lund, Sweden. In Drug Target Insights, 2014
Copeptin, midregional fragments of adrenomedullin, pro-atrial natriuretic peptide, and proenkephalin A, as well as N-terminal protachykinin A and proneurotensin were analyzed in the plasma.
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Breit et al., München, Germany. In Pharmacol Rev, 2014
However, several distinct peptides and amino acids are discussed as potential ligands, including β-alanine, angiotensin-(1-7), alamandine, GABA, cortistatin-14, and cleavage products of proenkephalin, pro-opiomelanocortin, prodynorphin, or proneuropeptide-FF-A.
Evolutionary and developmental contributions for understanding the organization of the basal ganglia.
Desfilis et al., Lleida, Spain. In Brain Behav Evol, 2013
Based on data on Nkx2.1, Islet1, LANT6 and proenkephalin, it appears that both cell types are also present in the globus pallidus/dorsal pallidum of chicken, frog and lungfish.
Gene therapy for the treatment of chronic peripheral nervous system pain.
Glorioso et al., Pittsburgh, United States. In Neurobiol Dis, 2012
This promise has been recently supported by a Phase-I human trial in which a replication-defective herpes simplex virus (HSV) vector was used to deliver the human pre-proenkephalin (hPPE) gene, encoding the natural opioid peptides met- and leu-enkephalin (ENK), to cancer patients with intractable pain resulting from bone metastases (Fink et al., 2011).
Reward processing by the opioid system in the brain.
Kieffer et al., Illkirch-Graffenstaden, France. In Physiol Rev, 2009
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin.
Characterization of zebrafish proenkephalin reveals novel opioid sequences.
Rodríguez et al., Salamanca, Spain. In Brain Res Mol Brain Res, 2003
new heptapeptide with putative differential activity than the other peptides derived from the mammalian proenkephalins
Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin.
Zimmer et al., Bethesda, United States. In Nature, 1996
Enkephalins are endogenous opioid peptides that are derived from a pre-proenkephalin precursor protein.
Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour.
Mizuno et al., In Nature, 1983
The complete amino acid sequence of adrenorphin was determined by microsequencing and corresponds to the sequence of the first eight amino acids of peptide E which is derived from proenkephalin A. Adrenorphin has also been identified chromatographically in normal human and bovine adrenal medulla.
Presence in brain of synenkephalin, a proenkephalin-immunoreactive protein which does not contain enkephalin.
Rossier et al., In Nature, 1983
The primary sequence of adrenal proenkephalin has recently been reported by three groups who have isolated and sequenced the cDNA for this prohormone.
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