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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein tyrosine phosphatase type IVA, member 1

PRL-1, PTP4A1, Plrg1
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Prolactin, PRL-3, OV-1, CAN, ACID
Papers on PRL-1
Discovery of conventional prolactin from the holocephalan elephant fish, Callorhinchus milii.
Hyodo et al., Kāne‘ohe, United States. In Gen Comp Endocrinol, Jan 2016
The conventional prolactin (PRL), also known as PRL1, is an adenohypophysial hormone that critically regulates various physiological events in reproduction, metabolism, growth, osmoregulation, among others.
miR-339-3p inhibits proliferation and metastasis of colorectal cancer.
Li et al., Guangzhou, China. In Oncol Lett, Nov 2015
Previously, the present authors reported that miR-339-5p could inhibit cell proliferation and migration by targeting the 3'-untranslated region (3'-UTR) of PRL-1 mRNA.
Application of serex-analysis for identification of human colon cancer antigens.
Filonenko et al., Ukraine. In Exp Oncol, Sep 2015
Through these five antigens, KY-CC-17/β-actin has cytoskeleton function; KY-CC-14/ACTR1A and KY-CC-19/TSGA2 participate in chromosome segregation; KY-CC-12/FKBP4 regulates steroid receptor function and KY-CC-15/PLRG1 is a component of spliceosome complex.
A New Genomewide Association Meta-Analysis of Alcohol Dependence.
Luo et al., Beijing, China. In Alcohol Clin Exp Res, Aug 2015
In meta-analysis of all 4 cohorts, we found 2 top-ranked SNPs in PTP4A1-PHF3 locus (6.0 × 10(-7) ≤ p ≤ 7.2 × 10(-7) ).
Identification of candidate genes that underlie the QTL on chromosome 1 that mediates genetic differences in stress-ethanol interactions.
Lu et al., Nantong, China. In Physiol Genomics, Aug 2015
In contrast, two other genes, the prenylated protein tyrosine phosphate family member Ptp4a1 (protein tyrosine phosphate 4a1) and the zinc finger protein Phf3 (plant homeoDomain finger protein 3) met each of our bioinformatic criteria and are thus strong candidates.
TANG1, Encoding a Symplekin_C Domain-Contained Protein, Influences Sugar Responses in Arabidopsis.
Jing et al., Beijing, China. In Plant Physiol, Jul 2015
Genetic analysis shows that PRL1 and TANG1 have additive effects on sugar-related responses.
The spliceosomal PRP19 complex of trypanosomes.
Günzl et al., Farmington, United States. In Mol Microbiol, Mar 2015
We identified a complex that contained the core subunits PRP19, CDC5, PRL1, and SPF27, as well as PRP17, SKIP and PPIL1.
PRL1 modulates root stem cell niche activity and meristem size through WOX5 and PLTs in Arabidopsis.
Li et al., Shijiazhuang, China. In Plant J, Feb 2015
In Arabidopsis thaliana, the Pleiotropic Regulatory Locus 1 (PRL1) encodes a WD40-repeat protein subunit of the spliceosome-activating Nineteen Complex (NTC) that plays a role in multiple stress, hormone and developmental signaling pathways.
PRL1, an RNA-binding protein, positively regulates the accumulation of miRNAs and siRNAs in Arabidopsis.
Yu et al., Lincoln, United States. In Plos Genet, 2014
The evolutionary conserved WD-40 protein PRL1 plays important roles in immunity and development.
Procyanidins Negatively Affect the Activity of the Phosphatases of Regenerating Liver.
Köhn et al., Heidelberg, Germany. In Plos One, 2014
Remarkably, the tested procyanidins showed selectivity in vitro when compared to other PPs, and over 10-fold selectivity toward PRL-1 over PRL-2 and PRL-3.
Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies.
Liu et al., Indianapolis, United States. In Cell Cycle, 2013
The phosphatases of regenerating liver (PRLs), consisting PRL1, PRL2 and PRL3, are dual-specificity protein phosphatases that have been implicated as biomarkers and therapeutic targets in several solid tumors.
Increased expression of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma.
Hu et al., Taiwan. In Clin Transl Oncol, 2012
upregulation of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma
PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
Zhang et al., Indianapolis, United States. In J Biol Chem, 2012
PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation
PRL-3 phosphatase and cancer metastasis.
Zeng et al., Singapore, Singapore. In J Cell Biochem, 2011
Importantly, PRL-1 and PRL-3 both possess the capacity to drive key steps in metastatic progression.
A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.
Luo et al., New Haven, United States. In Plos One, 2010
Data conclude that the PHF3-PTP4A1 region appears to harbor a causal locus for alcohol dependence, and proteins encoded by PHF3 and/or PTP4A1 might play a functional role in the disorder.
Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.
Lamond et al., Dundee, United Kingdom. In Embo Rep, 2010
A central region in hnRNP-M is required for interaction with CDC5L/PLRG1.
Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage.
Unger et al., Berlin, Germany. In Hypertens Res, 2010
Furthermore, the increasing complexity regarding the cellular function of the (P)RR is addressed, which arises by the intimate link with proton pumps and the phosphatase PRL-1, as well as by the presence of different subcellular localizations and of a soluble isoform of the (P)RR.
Pleiotropic regulatory locus 1 (PRL1) integrates the regulation of sugar responses with isoprenoid metabolism in Arabidopsis.
Rodríguez-Concepción et al., Barcelona, Spain. In Mol Plant, 2010
PRL1 appears to coordinate isoprenoid metabolism with sugar, hormone, and stress responses.
PRL PTPs: mediators and markers of cancer progression.
Pallen et al., Vancouver, Canada. In Cancer Metastasis Rev, 2008
Enhanced expression of the PRLs, notably PRL-1 and PRL-3, promotes the acquisition of cellular properties that confer tumorigenic and metastatic abilities.
PRL phosphatases as potential molecular targets in cancer.
Von Hoff et al., Tucson, United States. In Mol Cancer Ther, 2005
The phosphatase of regenerating liver (PRL) family of phosphatases, consisting of PRL-1, PRL-2, and PRL-3, represents an intriguing group of proteins being validated as biomarkers and therapeutic targets in cancer.
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