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Protein kinase, AMP-activated, gamma 1 non-catalytic subunit

PRKAG1, AMP-activated protein kinase subunit gamma 1
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AMPK, PRKAG2, PRKAG3, ACID, Actin
Papers on PRKAG1
A SNP in the 3'-untranslated region of AMPKγ1 may associate with serum ketone body and milk production of Holstein dairy cows.
Eghbalsaied et al., Eşfahān, Iran. In Gene, Jan 2016
In this study, we aimed to screen the PRKAG1 (AMPKγ1) gene in high, moderate, and low producing Holstein dairy cows.
Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators.
Vartiainen et al., Helsinki, Finland. In J Cell Sci, Aug 2015
We validate 19 factors as specific hits, and show that Chinmo (known as Bach2 in mammals), SNF4Aγ (Prkag1 in mammals) and Rab18 play a role in nuclear localization of actin in both fly and mammalian cells.
Rare coding variants and X-linked loci associated with age at menarche.
Perry et al., Boston, United States. In Nat Commun, 2014
Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are associated with age at menarche (minor allele frequencies 0.08-4.6%;
AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.
Redwood et al., Oxford, United Kingdom. In Circ Res, 2012
Conclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac function.
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
Singh et al., Hamilton, Canada. In Plos One, 2011
In breast cancer cells SESN2 is associated with AMPK.
Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.
Schumacker et al., Chicago, United States. In Mol Cell Biol, 2011
Findings reveal that hypoxia can trigger AMPK activation in the apparent absence of increased [AMP] through ROS-dependent CRAC channel activation, leading to increases in cytosolic calcium that activate the AMPK upstream kinase CaMKKbeta.
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
Shaw et al., Los Angeles, United States. In Nat Cell Biol, 2011
Studies indicate that in most species, AMPK exists as an obligate heterotrimer, containing a catalytic subunit (alpha), and two regulatory subunits (beta and gamma).
Structural insights into the architecture and allostery of full-length AMP-activated protein kinase.
Wu et al., Lanzhou, China. In Structure, 2011
Studies determine the three-dimensional reconstruction and subunit organization of the full-length rat AMPK (alpha1beta1gamma1) through single-particle electron
The AMPKγ1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia.
Viollet et al., Paris, France. In Faseb J, 2011
Results demonstrate that AMPKgamma1 subunit is required for the maintenance of erythrocyte membrane elasticity.
Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia.
Steen et al., Bergen, Norway. In Pharmacopsychiatry, 2011
METHODS: We genotyped tagSNPs in several genes ( ADIPOQ, PRKAA1, PRKAA2, PRKAB1, PRKAG1, PRKAG2, PRKAG3, FTO and FABP3) that regulate lipid and energy homeostasis for their possible association to antipsychotic-induced weight gain.
New indicators of beef sensory quality revealed by expression of specific genes.
Hocquette et al., France. In J Agric Food Chem, 2007
Among these, 23 were up-regulated in the tenderest, juiciest, and tastiest meats, and 18 were highly correlated with both flavor and juiciness (e.g., PRKAG1), explaining up to 60% of their variability.
Adenosine 5'-monophosphate kinase-activated protein kinase (PRKA) activators delay meiotic resumption in porcine oocytes.
Richard et al., Québec, Canada. In Biol Reprod, 2007
Porcine COC and DO contained transcripts that corresponded to the expected sizes of the designed primers for PRKAB1 and PRKAG1.
Characterization of the bovine ampkgamma1 gene.
Hickey et al., Lethbridge, Canada. In Mamm Genome, 2005
isolation and characterization of the gene for the noncatalytic bovine gamma1 subunit of AMPK
Determination of PRKAG1 coding sequence and mapping of PRKAG1 and PRKAG2 relatively to porcine back fat thickness QTL.
Milan et al., Solomon Islands. In Anim Genet, 2004
PRKAG1, PRKAG2 and PRKAG3 encode three isoforms of AMP-activated protein kinase gamma chain.
The bovine 5' AMPK gene family: mapping and single nucleotide polymorphism detection.
Womack et al., College Station, United States. In Mamm Genome, 2003
PRKAA1 mapped to BTA 20, PRKAA2 and PRKAB2 to BTA 3, PRKAB1 to BTA 17, PRKAG1 to BTA 5, PRKAG2 to BTA 4, and PRKAG3 to BTA 2. Five of the seven genes mapped to regions expected from human/cattle comparative maps.
Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36.
Zhao et al., Shanghai, China. In Genomics, 2001
In the present study, a homologue of the AMPK gamma1-subunit cDNA with an open reading frame encoding 328 amino acids was identified.
Cloning, organisation, chromosomal localization and expression analysis of the mouse Prkag1 gene.
Engel et al., Göttingen, Germany. In Cytogenet Cell Genet, 2000
The gene for AMPK-gamma-1 has been designated recently as PRKAG1.
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