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PBX/knotted 1 homeobox 2

PREP2, PKNOX2, PBX/knotted 1 homeobox 2
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009] (from NCBI)
Top mentioned proteins: ACID, Prep1, prolyl endopeptidase, TOP, Nrd1
Papers on PREP2
Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development.
Potter et al., Cincinnati, United States. In Bmc Dev Biol, 2014
In addition of the Hox mutants showed strongly altered expression of Pknox2, Zfp467, Gdf5, Bmpr1b, Dkk3, Igf1, Hand2, Shox2, Runx3, Bmp7 and Lef1, all of which have been previously shown to play important roles in bone formation.
Genome-wide association discoveries of alcohol dependence.
Luo et al., New Haven, United States. In Am J Addict, 2014
The variants located within or near SERINC2, KIAA0040, MREG-PECR or PKNOX2 were significantly associated with alcohol dependence at the genome-wide level (p < 5 × 10(-8) ) in meta-analysis or combined samples, and these associations were replicable across at least one sample.
Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation.
Guo et al., Shanghai, China. In Plos One, 2012
Compared to the in-depth investigations of Meis and Pbx protein functions, the role of Pknox2 in limb development remains unclear.
PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.
Zeng et al., Johnson City, United States. In J Mol Neurosci, 2012
The most significant association with FTD was observed with rs1783925 (p = 4.4 × 10(-7)) within PKNOX2 gene at 11q24.2 while the second interesting locus was rs2277644 (p = 1.18 × 10(-5)) within MYH13 at 17p13.
Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes are associated with congenital heart defects.
Bowles et al., Salt Lake City, United States. In Eur J Med Genet, 2012
The coding exons of PBX1-4, PKNOX1, PKNOX2, MEIS1-3, and PBXIP1 were amplified by polymerase chain reaction and the products analyzed on a lightscanner.
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.
Zeng et al., Johnson City, United States. In J Psychiatr Res, 2011
We confirmed the association of PKNOX2 at 11q24.4 with alcohol dependence.
The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
Zhang et al., New Haven, United States. In Plos One, 2010
Using data from several genomewide case-control studies, we identified a strong and significant association signal with a novel gene, PKNOX2, on chromosome 11 with the composite phenotype in European-origin women
The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells.
Adjaye et al., Berlin, Germany. In Plos One, 2009
For example, expression of the transcription factors, SIX6, EGR2, PKNOX2, HOXD4, HOXD10, DLX5 and RAXL1, known to regulate developmental processes, are retained in AFiPSCs and FiPSCs.
PKNOX2 gene is significantly associated with substance dependence in European-origin women.
Zhang et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2009
We identified a strong (odds ratio = 1.77) and significant (P value = 7E-8) association signal with the PBX/knotted 1 homeobox 2 (PKNOX2) gene on chromosome 11 in European-origin women with the composite phenotype.
Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.
Bergeson et al., Austin, United States. In Proc Natl Acad Sci U S A, 2006
Data from the general meta-analysis was further filtered by a congenic strain microarray set, from which cis-regulated candidate genes for an alcohol preference quantitative trait locus on chromosome 9 were identified: Arhgef12, Carm1, Cryab, Cox5a, Dlat, Fxyd6, Limd1, Nicn1, Nmnat3, Pknox2, Rbp1, Sc5d, Scn4b, Tcf12, Vps11, and Zfp291 and four ESTs.
The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors.
Schweizer et al., Heidelberg, Germany. In Arch Dermatol Res, 2006
We found that MEIS1, MEIS2, PREP1 and PREP2 were differentially expressed in the three layers of the inner root sheath.
Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1.
Peltonen et al., Los Angeles, United States. In Hum Mol Genet, 2005
The linkage disequilibrium (LD) and haplotype analyses of single nucleotide polymorphism (SNP) markers helped to further restrict the HLS locus to 476 kb between genes PKNOX2 and DDX25.
Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export.
Featherstone et al., Montréal, Canada. In J Biol Chem, 2004
transcriptional regulation by PREP2 is modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems
Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation.
Blasi et al., Milano, Italy. In Gene, 2004
This analysis identified transcripts for six HOX genes (A5, A9, B6, B7, C6 and C8) and two more TALE cofactors (PREP2 and Meis2).
Prep2: cloning and expression of a new prep family member.
Featherstone et al., Montréal, Canada. In Dev Dyn, 2002
Prep2 functions to varying degrees in a broad array of tissues and developmental processes.
Identification and characterization of human PKNOX2, a novel homeobox-containing gene.
Inazawa et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2001
This novel PKNOX-related protein may interact with PBX proteins and play a role in tissue-specific regulation of transcription.
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