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PR domain containing 4

The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD166, BAT, PRMT5, miR, NGF
Papers on PRDM4
Differential regulation of SC1/PRDM4 and PRMT5 mediated protein arginine methylation by the nerve growth factor and the epidermal growth factor in PC12 cells.
Chittka, London, United Kingdom. In Neurosci Lett, 2013
We recently showed that a member of the PRDM family of transcriptional regulators, PRDM4/SC1, recruits a type II protein arginine methyltransferase, PRMT5, to maintain the "stem-like" cellular state of the embryonic mouse cortical NSCs.
Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation.
Richardson et al., London, United Kingdom. In J Biol Chem, 2013
We investigated the role of Schwann cell factor 1 (SC1/PRDM4), a member of the PRDM family of transcription factors, in this critical transition.
The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells.
Chen et al., Tianjin, China. In Mol Cancer, 2012
Furthermore, we experimentally validated three of these candidates, MAP7 (microtubule-associated protein 7), PRDM4 (PR domain containing 4) and CDS2 (CDP-diacylglycerol synthase 2), as direct targets of miR-16.
Identification of recurrence-related genes by integrating microRNA and gene expression profiling of gastric cancer.
Zheng et al., Wuhan, China. In Int J Oncol, 2012
Finally, we identified HNRPA0 and PRDM4 as risk biomarkers of GC patients, which were regulated by hsa-miR‑194 and hsa-miR-373, respectively.
The PR/SET domain in PRDM4 is preceded by a zinc knuckle.
Ness et al., Missoula, United States. In Proteins, 2011
PRDM4 zinc knuckle by NMR spectroscopy.
Short- and long-term exposure to low levels of pesticide and flavonoid mixtures modify endogenous antioxidants in tissues of rats.
Bebe et al., Frankfort, United States. In J Environ Sci Health B, 2009
Our data indicate that (compared to corresponding Control groups): (i) While, 2 weeks of feeding reduced liver and small intestinal mucosal (IM) SOD activity in the PFM1 (PM+FM1) group, 4 weeks of feeding increased only liver SOD activity in PM, FM1, FM5 and PFM1 and PFM5 groups; (ii) Liver and IM GSH levels increased in PFM groups after 2 or 4 weeks of exposure; plasma GSH increased in the groups fed FM5 with or without PM; (iii) Liver GPX activity declined in both 2 and 4 week experiments in the FM and PFM groups, respectively.
[Refinement of DSAP1 locus and mutation detection for candidate genes].
Huang et al., Shanghai, China. In Yi Chuan Xue Bao, 2005
DNA sequencing of the coding exons of six candidate genes (CRY1, PWP1, ASCL4, PRDM4, KIAA0789 and CMKLR1) on the basis of their location in the critical overlap interval, failed to detect any mutation in DSAP patients.
A novel locus for parietal foramina maps to chromosome 4q21-q23.
He et al., Shanghai, China. In J Hum Genet, 2002
PFM types 1 and 2 (PFM1 and PFM2) have been found to be caused by mutations in the MSX2 and ALX4 genes, located to chromosomes 5 and 11, respectively.
PFM1 (PRDM4), a new member of the PR-domain family, maps to a tumor suppressor locus on human chromosome 12q23-q24.1.
Huang et al., Los Angeles, United States. In Genomics, 1999
This paper describes a new human PR family member, designated PFM1 (HGMW-approved symbol PRDM4).
Delay lines and amplitude selectivity are created in subthalamic auditory nuclei: the brachium of the inferior colliculus of the mustached bat.
Suga et al., Saint Louis, United States. In J Neurophysiol, 1993
They are tuned to particular delays of echo FMn (EFMn) (n = 2, 3, or 4) from pulse FM1 (PFM1).
Combination-sensitive neurons in the medial geniculate body of the mustached bat: encoding of target range information.
Suga et al., Saint Louis, United States. In J Neurophysiol, 1991
Thus the pulse-echo pair contains eight CF components (PCF1-4, ECF1-4) and eight FM components (PFM1-4, EFM1-4).
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