The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function.
Birmingham, United States. In Proc Natl Acad Sci U S A, Feb 2016
Subunits of polycomb repressive complex 1 (PRC1), the major histone H2A ubiquitin ligase, are critical for both normal and pathological hematopoiesis; however, it is unclear which of the several counteracting H2A deubiquitinases functions along with PRC1 to control H2A ubiquitination (ubH2A) level and regulates hematopoiesis in vivo.
PcG and trxG in plants - friends or foes.
Berkeley, United States. In Trends Genet, May 2015
Recent progress in Arabidopsis research challenges the dominant model of PRC2-dependent recruitment of PRC1 to target genes.
Epigenetic modifiers in normal and malignant hematopoiesis.
Aurora, United States. In Epigenomics, 2014
In this review, we aim to compare the role of several key DNA or histone modifying enzymes and complexes in normal development and hematopoietic malignancies, including DNMT3A, TET2, IDH1, IDH2, MLL1, MLL4, DOT1L, PRC1/2 and WSHC1/NSD2/MMSET.