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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Retinoblastoma 1

pRb, RB1
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p53, PCNA, p16, CAN, p21
Papers using pRb antibodies
In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer
Liao D. Joshua et al., In Journal of Cancer, 2006
... The anti-pRb Ser780 (Cat#9307) rabbit polyclonal antibody was purchased from Cell Signaling Technology, Inc (Danvers, MA) ...
A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells
Crescenzi Marco et al., In The Journal of Cell Biology, 1996
... Western blotting: pRb, clone G3-245 (BD Biosciences); p107, clone SD9; p130, ...
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein
Miller Freda D. et al., In The Journal of Cell Biology, 1992
... The pRb-deficient transgenic mice originally generated by ...
Calculation of Conformational Ensembles from Potentials of Mean Force: an approach to the knowledge based prediction of local structures in globular proteins
Seabra Laurence A et al., In Molecular Cancer, 1967
... at 1/250, Cdk6 - rabbit polyclonal sc-260 at 1/250, pRb 105 rabbit polyclonal sc-50 at 1/1000, pRb 110 (hyperphosphorylated) rabbit polyclonal sc-32824 at 1/500 (All from Santa Cruz Biotechnology Inc, Bergheime Str 89-2, ...
Papers on pRb
Incidental germline variants in 1000 advanced cancers on a prospective somatic genomic profiling protocol.
Chen et al., Houston, United States. In Ann Oncol, Feb 2016
RESULTS: Of the 1000 patients who underwent sequencing, 43 had likely pathogenic germline variants: APC (1), BRCA1 (11), BRCA2 (10), TP53 (10), MSH2 (1), MSH6 (4), PALB2 (2), PTEN (2), TSC2 (1), and RB1 (1).
Whole exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations.
Gomez-Brouchet et al., Toulouse, France. In Ann Oncol, Feb 2016
TP53 and RB1 show recurrent somatic alterations in concordant studies, suggesting that they could be key players in bone oncogenesis.
[Detection of copy number variations in pediatric ETV6/RUNX1-positive acute lymphoblastic leukemia with multiplex ligation-dependent probe amplification].
Zhu et al., Tianjin, China. In Zhongguo Dang Dai Er Ke Za Zhi, Jan 2016
The CNVs of EBF1, CDKN2A/2B, PAX5, ETV6, RB1, and BTG1 were detected in more than 10% of all the patients.
[Retinoblastoma update].
Doz et al., Paris, France. In Arch Pediatr, Jan 2016
All children with a bilateral or familial form, and 10-15% of children with a unilateral form, constitutionally carry an RB1 gene mutation.
Germline Mutations in Predisposition Genes in Pediatric Cancer.
Downing et al., Memphis, United States. In N Engl J Med, Jan 2016
The most commonly mutated genes in the affected patients were TP53 (in 50 patients), APC (in 6), BRCA2 (in 6), NF1 (in 4), PMS2 (in 4), RB1 (in 3), and RUNX1 (in 3).
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
Palomero et al., New York City, United States. In Nat Genet, Dec 2015
These analyses identified a distinctive pattern of somatic copy number alterations in Sézary syndrome, including highly prevalent chromosomal deletions involving the TP53, RB1, PTEN, DNMT3A and CDKN1B tumor suppressors.
Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.
Tessem et al., Provo, United States. In J Diabetes Res, Dec 2015
Overexpression of Cdk5r1 results in pRb phosphorylation, which is inhibited by roscovitine treatment.
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Morgan et al., Newcastle upon Tyne, United Kingdom. In J Clin Oncol, Dec 2015
RESULTS: We identified 15 significantly mutated genes: IRF4, KRAS, NRAS, MAX, HIST1H1E, RB1, EGR1, TP53, TRAF3, FAM46C, DIS3, BRAF, LTB, CYLD, and FGFR3.
The Spectrum of E2F in Liver Disease - Mediated Regulation in Biology and Cancer.
Leone et al., Columbus, United States. In J Cell Physiol, Dec 2015
The activation of E2Fs is intimately regulated by retinoblastoma 1 (RB1).
Treatment of Retinoblastoma: The Role of External Beam Radiotherapy.
Park et al., South Korea. In Yonsei Med J, Nov 2015
The risk of radiotherapy-related secondary cancers in children with constitutional retinoblastoma 1 (RB1) mutations has led to reduced use of external beam radiotherapy (EBRT) for RB.
Novel Biomarker Signature That May Predict Aggressive Disease in African American Men With Prostate Cancer.
Schaeffer et al., Philadelphia, United States. In J Clin Oncol, Oct 2015
and RB1 (P = .037)
Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations.
Borczuk et al., Guangzhou, China. In J Clin Oncol, Aug 2015
RESULTS: In addition to confirming mutations in known cancer-associated genes (TP53, KRAS, PIK3CA, MET, NOTCH, STK11, and RB1), several novel mutations in additional genes, including RASA1, CDH4, CDH7, LAMB4, SCAF1, and LMTK2, were identified and validated.
Molecular concept in human oral cancer.
Pal et al., Lucknow, India. In Natl J Maxillofac Surg, 2015
Several oncogenes and tumor suppressor genes have been implicated in oral cancer especially cyclin family, ras, PRAD-1, cyclin-dependent kinase inhibitors, p53 and RB1.
Critical genes in head and neck squamous cell carcinoma revealed by bioinformatic analysis of gene expression data.
Li et al., Hangzhou, China. In Genet Mol Res, 2014
Five PPI networks were constructed from which hub genes were acquired, such as minichromosome maintenance complex component 7 (MCM7), MCM2, decorin (DCN), retinoblastoma 1 (RB1), and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma (YWHAG).
A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response.
Tang et al., Hamilton, Canada. In Biomolecules, 2014
The locus encodes the p16INK4A and p14/p19ARF tumor suppressors that function in the pRb and p53 pathways, respectively.
Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications.
Hornick et al., Boston, United States. In Am J Surg Pathol, 2012
of the soft tissue tumors associated with 13q deletions, all spindle cell lipomas, pleomorphic lipomas, and cellular angiofibromas and most mammary-type myofibroblastomas show loss of Rb expression
The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.
Lowe et al., New York City, United States. In Genes Dev, 2012
identify a causal role for E2F7 in cellular senescence and uncover a novel link between the RB and p53 pathways.
p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells.
Sarkaria et al., Rochester, United States. In Neuro Oncol, 2012
RB mutation is associated with drug sensitivity in glioblastoma.
Parental diet and risk of retinoblastoma resulting from new germline RB1 mutation.
Ganguly et al., Philadelphia, United States. In Environ Mol Mutagen, 2012
study observed associations between father's diet before his child's conception and risk of retinoblastoma in his child that results from a new germline RB1 mutation
RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation.
Hamamoto et al., Tokyo, Japan. In Neoplasia, 2012
-dependent RB1 methylation at lysine 810 promotes cell cycle progression of cancer cells. Further study may explore SMYD2-dependent RB1 methylation as a potential therapeutic target in human cancer.
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