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MAP kinase-activated protein kinase 5

PRAK, MK5, MAPK-activated protein kinase 5, MAPKAPK5, p38-regulated/activated protein kinase
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAPK, p38, SF-1, CAN, ERK3
Papers using PRAK antibodies
Phosphate-binding tag, a new tool to visualize phosphorylated proteins
Moens Ugo et al., In Cellular and Molecular Life Sciences, 2005
... Activated PRAK was from Millipore Upstate (Billerica, MA), while purified PKA was from Promega Corporation (Madison, WI) ...
Papers on PRAK
New insights into the activation, interaction partners and possible functions of MK5/PRAK.
Seternes et al., Tromsø, Norway. In Front Biosci, Dec 2015
MAP kinase-activated protein kinase 5 (MK5) was first described as a downstream target of the p38 MAP kinase pathway leading to its alternative acronym of p38-regulated/activated protein kinase (PRAK).
The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer's disease pathogenesis.
Mook-Jung et al., Seoul, South Korea. In Mol Neurodegener, Dec 2015
RESULTS: In this study, we identified p38-regulated/activated protein kinase (PRAK) as a novel RAGE interacting molecule.
A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration.
Wells et al., Norway. In Cell Adh Migr, Dec 2015
MK5 (MAP kinase- activated protein kinase 5) also called PRAK is the only known substrate for ERK3.
Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer.
Huang et al., Fuzhou, China. In Oncol Lett, Sep 2015
It was previously reported that upon energy-stress stimulation, the phosphorylation of Rheb at serine 130 by p38-regulated/activated protein kinase (PRAK) results in the impaired nucleotide binding ability of Rheb and inhibits Rheb-mediated mTORC1 activation.
Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK.
Gaestel et al., Hannover, Germany. In Plos One, 2014
MK5 (MAPK-activated protein kinase 5) or PRAK (p38-regulated and -activated kinase) are alternative names for a serine/threonine protein kinase downstream to ERK3/4 and p38 MAPK.
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes.
Dobson et al., London, United Kingdom. In Transl Psychiatry, 2014
The plasma level of the mitogen-activated protein kinase (MAPK) MAPKAPK5 protein was found to positively associate with the 10-year change in CANTAB-PAL in both the individual and twin difference context.
MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges.
Gaestel, Hannover, Germany. In Front Cell Dev Biol, 2014
This short review will summarize recent developments including the linear motif (LM) in MKs, the ERK-independent activation of RSK, the RSK-independent effects of some RSK-inhibitors and the challenged role of MK5/PRAK in tumor suppression.
Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma.
Lai et al., Hong Kong, Hong Kong. In Plos One, 2014
Six lncRNAs (CECR7, LINC00346, MAPKAPK5-AS1, LOC338651, FLJ90757, and LOC283663) were found to be significantly associated with overall survival (OS, log-rank P < 0.05).
Structure and function of MK5/PRAK: the loner among the mitogen-activated protein kinase-activated protein kinases.
Kostenko et al., Tromsø, Norway. In Biol Chem, 2013
Eleven mammalian MAPK-activated protein kinases have been identified, and they are divided into five subgroups: the ribosomal-S6-kinases RSK1-4, the MAPK-interacting kinases MNK1 and 2, the mitogen- and stress-activated kinases MSK1 and 2, the MAPK-activated protein kinases MK2 and 3, and the MAPK-activated protein kinase MK5 (also referred to as PRAK).
The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.
Kotlyarov et al., Hannover, Germany. In Mol Cell Biol, 2012
the regulation of neuronal morphogenesis is proposed as the first physiological function of the ERK3/MK5 signaling module
PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway.
Sun et al., Los Angeles, United States. In Mol Cancer Res, 2012
Results suggest that PRAK may function as a tumor suppressor in multiple types of cancers.
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis.
Sun et al., Los Angeles, United States. In Mol Cell Biol, 2012
It was shown that the tumor-suppressing and tumor-promoting functions of the p38-PRAK pathway are temporally and spatially separated during cancer development in vivo, relying on the stimulus, and the tissue type and the stage of cancer development.
IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.
Hüttelmaier et al., Halle, Germany. In Genes Dev, 2012
IGF2BP1 promotes the velocity and directionality of tumor-derived cell migration by determining the cytoplasmic fate of two novel target mRNAs: MAPK4 and PTEN
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
Han et al., Xiamen, China. In Nat Cell Biol, 2011
Rheb inactivation by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.
Roux et al., Montréal, Canada. In Microbiol Mol Biol Rev, 2011
There are five MAPKAPK subfamilies: the p90 ribosomal S6 kinase (RSK), the mitogen- and stress-activated kinase (MSK), the MAPK-interacting kinase (MNK), the MAPK-activated protein kinase 2/3 (MK2/3), and MK5 (also known as p38-regulated/activated protein kinase [PRAK]).
Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5.
Moens et al., Tromsø, Norway. In J Recept Signal Transduct Res, 2011
This review discusses the different characteristics of regulating the activity and subcellular localization of MK5 and RSK1 by PKA and the functional implications of these interactions.
Oncogene-induced senescence pathways weave an intricate tapestry.
Campisi et al., Berkeley, United States. In Cell, 2007
They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.
PRAK is essential for ras-induced senescence and tumor suppression.
Han et al., Los Angeles, United States. In Cell, 2007
We propose that phosphorylation of p53 by PRAK following activation of p38 MAPK by ras plays an important role in ras-induced senescence and tumor suppression.
MAPKAP kinases - MKs - two's company, three's a crowd.
Gaestel, Hannover, Germany. In Nat Rev Mol Cell Biol, 2006
Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs) - MK2, MK3 and MK5 - signal to diverse cellular targets.
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