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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Prostate cancer susceptibility candidate

This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, STEP, HOXB13, AGE, HAD
Papers on PRAC
[Codeine--Restrictions on use for children and teenagers].
Rotthauwe et al., Bonn, Germany. In Dtsch Med Wochenschr, Jul 2015
The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency has issued European-wide restrictions on the use of codeine-containing medicines for cough and cold in children at the age of 0-12 because of the risk of serious side effects, including the risk of breathing problems.
Benefit-risk assessment of diacerein in the treatment of osteoarthritis.
Jones et al., Hobart, Australia. In Drug Saf, Mar 2015
In addition, the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) questioned the limited clinical benefits of diacerein, which, in their view, did not outweigh its risks.
Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences.
G Teixeira et al., São Paulo, Brazil. In Parasit Vectors, 2014
BACKGROUND: Proline racemase (PRAC) enzymes of Trypanosoma cruzi (TcPRAC), the agent of Chagas disease, and Trypanosoma vivax (TvPRAC), the agent of livestock trypanosomosis, have been implicated in the B-cells polyclonal activation contributing to immunosuppression and the evasion of host defences.
Safety referral procedures clarified.
In Prescrire Int, 2014
In both cases, the Pharmacovigilance Risk Assessment Committee (PRAC) issues a recommendation that the marketing authorisation committees concerned must take into account when formulating their opinions.
Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon.
Srivastava et al., United States. In Mod Pathol, 2014
Among CpG loci with the largest difference in methylation between right- and left-colon adenomas, probes associated with PRAC (prostate cancer susceptibility candidate) gene showed hypermethylation in right-colon adenomas whereas those associated with CDX2 (caudal type homeobox transcription factor 2) showed hypermethylation in left-colon adenomas.
Aberrant expression of the PRAC gene in prostate cancer.
Pang et al., Taipei, Taiwan. In Int J Oncol, 2013
We analysed the expression patterns of prostate cancer susceptibility candidate (PRAC) in prostate cancer.
Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancer.
Liu et al., Shanghai, China. In Dis Markers, 2011
Eighty two hypermethylated genes were acquired by array analysis and 5 genes (BCAS4, CHRM2, FAM5C, PRAC and MYLK) were selected as the candidate genes.
Effects of treadmill exercise on behavioral recovery and neural changes in the substantia nigra and striatum of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse.
Meshul et al., Beaverton, United States. In Brain Res, 2011
We measured recovery of gait performance and amount of spontaneous physical activity using the parallel rod activity chamber (PRAC).
Proline racemases are conserved mitogens: characterization of a Trypanosoma vivax proline racemase.
Minoprio et al., Paris, France. In Mol Biochem Parasitol, 2009
Despite the high degree of gene synteny observed in Kinetoplastidae genomes, PRAC genes are missing in Trypanosoma brucei, Trypanosoma congolense and Leishmania spp.
Molecular and structural discrimination of proline racemase and hydroxyproline-2-epimerase from nosocomial and bacterial pathogens.
Minoprio et al., Paris, France. In Plos One, 2006
The first eukaryotic proline racemase (PRAC), isolated from the human Trypanosoma cruzi pathogen, is a validated therapeutic target against Chagas' disease.
[Influence and significance of preoperative intraarterial infusion chemotherapy combined with radiotherapy on survivin, p53 and Bax expression in low rectal carcinoma].
Liu et al., Nanning, China. In Ai Zheng, 2006
BACKGROUND & OBJECTIVE: Recently, neoadjuvant therapy has attracted more attention, but the influence of preoperative intraarterial infusion chemotherapy (PRAC) combined with radiotherapy on Survivin expression in rectal carcinoma is unclear.
Intermanual transfer effects in sequential tactuomotor learning: evidence for effector independent coding.
Petersen et al., Maastricht, Netherlands. In Neuropsychologia, 2005
Errors and velocity were measured during the following conditions: initial naive performance (Naive); after practice on the maze (Prac); during intermanual transfer to the same maze (Transfer Identical); and to the mirror maze (Transfer Mirror).
Expression analysis onto microarrays of randomly selected cDNA clones highlights HOXB13 as a marker of human prostate cancer.
Cooper et al., Male, Maldives. In Br J Cancer, 2005
DNA sequencing of the selected clones revealed that they included 10 genes that had previously been established as prostate markers: NKX3.1, KLK2, KLK3 (PSA), FOLH1 (PSMA), STEAP2, PSGR, PRAC, RDH11, Prostein and FASN.
PRAC2: a new gene expressed in human prostate and prostate cancer.
Pastan et al., Bethesda, United States. In Prostate, 2003
BACKGROUND: The database of human Expressed Sequence Tags was previously used to identify PRAC (Prostate 47:125-131, 2001), a novel gene specifically expressed in human prostate, prostate cancer, rectum, and distal colon.
PRAC: A novel small nuclear protein that is specifically expressed in human prostate and colon.
Pastan et al., Bethesda, United States. In Prostate, 2001
In this report, we have used the EST database to identify PRAC, a novel gene specifically expressed in human Prostate, prostate cancer, Rectum And distal Colon.
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