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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

PPR1 Ppr1p

PPR1, CCX-CKR, Ppr1p, CCR11
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, glycoprotein D, CAN, GAL4, V1a
Papers on PPR1
Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells.
Behjati et al., Eşfahān, Iran. In Mol Cell Biochem, Jan 2016
CCX-CKR (CCRL1) as one of the chemokine receptor-like proteins is a scavenger of CCL19, CCL21, CCL25, and CXCL13 chemokines.
Gene Cloning and Characterization of the Geobacillus thermoleovorans CCR11 Carboxylesterase CaesCCR11, a New Member of Family XV.
Oliart-Ros et al., Veracruz, Mexico. In Mol Biotechnol, Jan 2016
A gene encoding a carboxylesterase produced by Geobacillus thermoleovoras CCR11 was cloned in the pET-3b cloning vector, sequenced and expressed in Escherichia coli BL21(DE3).
Improved growth and ethanol fermentation of Saccharomyces cerevisiae in the presence of acetic acid by overexpression of SET5 and PPR1.
Bai et al., Dalian, China. In Biotechnol J, Dec 2015
To better understand the contribution of zinc-finger proteins to environmental stress tolerance, particularly inhibition from acetic acid, which is a potent inhibitor for cellulosic ethanol production by microbial fermentations, SET5 and PPR1 were overexpressed in Saccharomyces cerevisiae BY4741.
Improved expression and immobilization of Geobacillus thermoleovorans CCR11 thermostable recombinant lipase.
Sánchez-Otero et al., Veracruz, Mexico. In Biotechnol Appl Biochem, Oct 2015
UNASSIGNED: Production of recombinant thermo-alkali-stable lipase LipMatCCR11, expressed in E. coli BL21 (DE3), was investigated via response surface methodology by using a face-centered design with three levels of each factor.
Absence of multiple atypical chemokine binders (ACBs) and the presence of VEGF and MMP-9 predict axillary lymph node metastasis in early breast carcinomas.
Shao et al., Chongqing, China. In Med Oncol, 2014
The aim of this study was to determine the frequency of axillary lymph node (ALN) metastasis of early breast cancers by evaluating the status of DARC, D6 and CCX-CKR and the levels of VEGF and MMP-9.
Pentatricopeptide repeat motifs in the processing enzyme PRORP1 in Arabidopsis thaliana play a crucial role in recognition of nucleotide bases at TψC loop in precursor tRNAs.
Kimura et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2014
Although Δ89, in which all PPR motifs are present, retained the pre-tRNA cleavage activity, Δ129 devoid of the first PPR motif (PPR1) had significantly reduced cleavage activity.
A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system.
McColl et al., Adelaide, Australia. In Cytokine Growth Factor Rev, 2013
In particular we highlight CCX-CKR, which scavenges both CCR7 ligands, and discuss its emerging significance in the immune system.
Potential combinatorial effects of recombinant atypical chemokine receptors in breast cancer cell invasion: A research perspective.
Khoo et al., George Town, Malaysia. In Biomed Rep, 2013
The identification and characterization of a group of atypical chemokine receptors [D6, Duffy antigen receptor for chemokines (DARC), ChemoCentryx chemokine receptor (CCX-CKR) and CXCR7] which appear to use unique biochemical properties to regulate the biological activities of these chemokines, is useful in the effort to therapeutically manipulate chemokines in a broad spectrum of diseases in which these chemokines play a critical role.
Chemokine-like receptor 1 (CMKLR1) and chemokine (C-C motif) receptor-like 2 (CCRL2); two multifunctional receptors with unusual properties.
Oppenheim et al., Frederick, United States. In Exp Cell Res, 2011
Like Duffy antigen for chemokine receptor (DARC), D6 and CCX-CKR, CCRL2 does not signal, but it constitutively recycles, potentially reducing local concentration of CCL5 and CCL19 and subsequent immune responses.
The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses.
McColl et al., Adelaide, Australia. In Blood, 2010
CCX-CKR(-/-) have a 5-fold increase in the level of CCL21 protein in blood, and 2- to 3-fold increases in CCL19 and CCL21 in peripheral lymph nodes.
Involvement of a novel chemokine decoy receptor CCX-CKR in breast cancer growth, metastasis and patient survival.
Shao et al., Shanghai, China. In Clin Cancer Res, 2009
Down regulation of CCX-CKR is associated with breast cancer.
Chemokine decoy receptors: new players in reproductive immunology.
Locati et al., Rozzano, Italy. In Immunol Invest, 2007
Recently, a group of chemokine receptors, which include D6, DARC, and CCX-CKR, have been described as "silent" receptors by virtue of their inability to activate signal transduction events leading to cell chemoattraction.
A silent chemokine receptor regulates steady-state leukocyte homing in vivo.
Bleul et al., Freiburg, Germany. In Proc Natl Acad Sci U S A, 2007
These observations indicate that the silent chemokine receptor CCX-CKR1, regulates homeostatic leukocyte migration by controlling the availability of chemokines in the extracellular space.
[Interceptors:--"silent" chemokine receptors].
Waśniowska et al., Poland. In Postepy Hig Med Dosw (online), 2006
Three of them (Duffy glycoprotein, D6, and CCX-CKR proteins), although structurally related to other GPCRs, lack the ability of G-protein signal transduction.
The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro.
Nibbs et al., Glasgow, United Kingdom. In Eur J Immunol, 2006
Scavenges extracellular chemokines in vivo to modify responses through CCR7.
International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature.
Murphy, Bethesda, United States. In Pharmacol Rev, 2002
An update of the International Union of Pharmacology nomenclature for chemokines is outlined, defining one new receptor type, CXCR6, and disqualifying the putative receptor, CCR11.
Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.
Nibbs et al., Glasgow, United Kingdom. In Eur J Immunol, 2002
Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. (CCX-CKR)
GAL11P: a yeast mutation that potentiates the effect of weak GAL4-derived activators.
Ptashne et al., Cambridge, United States. In Cell, 1991
PPR1, a yeast activator with a similar zinc finger sequence, also responds to GAL11 and to GAL11P, whereas regulators bearing unrelated DNA binding motifs do not.
Altering DNA-binding specificity of GAL4 requires sequences adjacent to the zinc finger.
Johnston et al., Durham, United States. In Nature, 1989
By contrast, our results demonstrate that all but one of the 28 amino acids encompassing the single zinc-finger region of GAL4, the yeast transcriptional activator, can be replaced with the analogous zinc-finger region from another yeast-activator protein, PPR1, without changing the DNA-binding specificity of GAL4.
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