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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein phosphatase 6, catalytic subunit

This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PP6, CAN, BRAF, Rac1, N-ras
Papers using PPP6C antibodies
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... Santa Cruz Biotechnology, Inc.), Aurora A (rabbit AB12875; Abcam), Aurora A pT288 (rabbit 3079; Cell Signaling Technology), PPP6C (rabbit A300-844A; Bethyl Laboratories, Inc.), SAPS1–3 (rabbit ...
Papers on PPP6C
The Anaphase-Promoting Complex/Cyclosome Is Essential for Entry into Meiotic M-Phase.
Mayer et al., Konstanz, Germany. In Dev Cell, Feb 2016
We identify the catalytic subunit of protein phosphatase 6 (PP6c) as the critical substrate whose APC/C(Cdh1)-mediated destruction is a prerequisite for the re-entry of immature Xenopus laevis oocytes into MI.
Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility.
Sun et al., Beijing, China. In J Cell Sci, Nov 2015
To identify the physiological role of PP6 in female gametogenesis, Ppp6c(F/F) mice were first generated and crossed with Zp3-Cre mice to selectively disrupt Ppp6c expression in oocytes.
Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells.
Kettenbach et al., United States. In Sci Signal, Nov 2015
We applied a baculovirus-mediated gene silencing approach to deplete HeLa cells of the catalytic subunit of PP6 (PP6c) and analyzed changes in the phosphoproteome and proteome in mitotic cells by quantitative mass spectrometry-based proteomics.
Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan.
Nakamura et al., Isehara, Japan. In Mod Pathol, Oct 2015
The cases were characterized by immunohistochemistry, high-resolution oligonucleotide microarray, and fluorescence in situ hybridization (FISH) at five different loci: 1q21.3 (CKS1B), 6q16.3 (HACE1), 7p22.3 (MAFK), 9q33.3 (PPP6C), and 9q34.3 (ASS1, CARD9) using formalin-fixed paraffin-embedded sections.
Mutational status of naevus-associated melanomas.
Bagatin et al., São Paulo, Brazil. In Br J Dermatol, Sep 2015
MATERIALS AND METHODS: Sixty-one melanomas found in association with a pre-existing naevus were microdissected, after careful selection of cell subpopulations, and submitted to Sanger sequencing of the BRAF, NRAS, c-KIT, PPP6C, STK19 and RAC1 genes.
Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication.
Fodor et al., Oxford, United Kingdom. In J Virol, 2014
Among the phosphatases, we identified three subunits of the cellular serine/threonine protein phosphatase 6 (PP6), including the catalytic subunit PPP6C and regulatory subunits PPP6R1 and PPP6R3.
A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance.
Zhao et al., Nashville, United States. In Mol Cancer Ther, 2014
First, we uncovered several genes whose mutations were more likely associated with BRAF- or NRAS-driven melanomas, including TP53 and COL1A1 with BRAF, and PPP6C, KALRN, PIK3R4, TRPM6, GUCY2C, and PRKAA2 with NRAS.
PP6C hotspot mutations in melanoma display sensitivity to Aurora kinase inhibition.
Gardner et al., New York City, United States. In Mol Cancer Res, 2014
UNLABELLED: Recent whole genome melanoma sequencing studies have identified recurrent mutations in the gene encoding the catalytic subunit of serine/threonine phosphatase 6 (PPP6C/PP6C).
[Ultraviolet A-induced DNA damage: role in skin cancer].
Beani, In Bull Acad Natl Med, 2014
These mutations target the p53, patched 1 and SMO genes in carcinomas, and the PTEN RAC1, PPP6C, STK19 and PPP6C genes in melanomas of exposed skin.
Identification of thyroid carcinoma related genes with mRMR and shortest path approaches.
Fan et al., Shanghai, China. In Plos One, 2013
In this study, we focus on the transcriptome difference among PTCs, ATCs and normal tissue from a published dataset including 45 normal tissues, 49 PTCs and 11 ATCs, by applying a machine learning method, maximum relevance minimum redundancy, and identified 9 genes (BCL2, MRPS31, ID4, RASAL2, DLG2, MY01B, ZBTB5, PRKCQ and PPP6C) and 1 miscRNA (miscellaneous RNA, LOC646736) as important candidates involved in the progression of thyroid cancer.
"Omics" of human sperm: profiling protein phosphatases.
da Cruz e Silva et al., Aveiro, Portugal. In Omics, 2013
This article examines the "Omics" of human sperm, and reports, for the first time, the identification of three new serine/threonine-protein PPs, PPP1CB, PPP4C, and PPP6C, in human sperm, together with two tyrosine-PPs, MKP1 and PTP1C.
[Melanoma: from molecular studies to the treatment breakthrough].
Imianitov, In Arkh Patol, 2013
Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions.
Brautigan et al., Charlottesville, United States. In Bmc Cell Biol, 2012
RESULTS: This study shows protein Ser/Thr phosphatase-6 catalytic subunit (PP6c) is expressed in epithelial tissue and its mRNA and protein are robustly up-regulated in epithelial cell lines at high vs. low density.
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Halaban et al., New Haven, United States. In Nat Genet, 2012
Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS.
A landscape of driver mutations in melanoma.
Chin et al., Cambridge, United States. In Cell, 2012
Analysis of large-scale melanoma exome data by this approach discovered six novel melanoma genes (PPP6C, RAC1, SNX31, TACC1, STK19, and ARID2), three of which-RAC1, PPP6C, and STK19-harbored recurrent and potentially targetable mutations.
MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma.
Tang et al., Tianjin, China. In Febs J, 2011
miR-373 can regulate cell cycle progression by targeting PPP6C transcripts and promotes the growth activity of HCC cells in vitro. The downregulation of PPP6C by miR-373 may explain why the expression of miR-373 can promote HCC cell proliferation.
Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks.
Xu et al., Taiwan. In Cell Cycle, 2011
PP6 is required for non-homologous end joining repair; its expression may harbor a protective role during the development of breast cancer tissues.
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.
Gruneberg et al., Liverpool, United Kingdom. In J Cell Biol, 2011
Results demonstrate a role for PP6 as the T-loop phosphatase regulating Aurora A activity bound to its activator TPX2 during mitotic spindle formation.
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.
Lees-Miller et al., Calgary, Canada. In Mol Cell Biol, 2010
A novel function of DNA-PKcs is to recruit PP6 to sites of DNA damage and that PP6 contributes to the dephosphorylation of gamma-H2AX, the dissolution of ionizing radiation-induced foci, and release from the G(2)/M checkpoint in vivo.
Lack of replication of celiac disease risk variants reported in a Spanish population using an independent Spanish sample.
Núñez et al., Madrid, Spain. In Genes Immun, 2009
our results seem to discard the role of the previously described polymorphisms in SERPINE2, PPP6C and PBX3 in celiac disease susceptibility.
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