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Protein phosphatase 1, catalytic subunit, beta isozyme

PPP1CB, PPI b, protein phosphatase 1beta, PP1b
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, PP1, AGE, HAD, pp1a
Papers on PPP1CB
Phosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis.
Kang et al., Seoul, South Korea. In Biochem Biophys Res Commun, Dec 2015
Here, we demonstrate a novel role for phosphoprotein phosphatase 1CB (PPP1CB) as a potent adipogenic activator that promotes adipocyte differentiation.
Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer.
Polenakovic et al., Скопје, Macedonia. In Prostate, Oct 2015
We evidenced for the first time the dysregulation of 9 proteins (CSNK1A1, ARID5B, LYPLA1, PSMB6, RABEP1, TALDO1, UBE2N, PPP1CB, and SERPINB1) that may have role in PCa.
STRIPAK components determine mode of cancer cell migration and metastasis.
Sahai et al., London, United Kingdom. In Nat Cell Biol, 2015
We show that FAM40A negatively regulates the MST3 and MST4 kinases, which promote the co-localization of the contractile actomyosin machinery with the Ezrin/Radixin/Moesin family proteins by phosphorylating the inhibitors of PPP1CB, PPP1R14A-D.
The neuronal-specific SGK1.1 (SGK1_v2) kinase as a transcriptional modulator of BAG4, Brox, and PPP1CB genes expression.
Martín-Vasallo et al., Santa Cruz de Tenerife, Spain. In Int J Mol Sci, 2014
The Serum- and Glucocorticoid-induced Kinase 1, SGK1, exhibits a broad range of cellular functions that include regulation of the number of ion channels in plasma membrane and modulation of signaling pathways of cell survival.
The YPEL5-PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples.
Denys et al., Gent, Belgium. In Leuk Res Rep, 2014
It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%).
De novo mutations in moderate or severe intellectual disability.
Michaud et al., Montréal, Canada. In Plos Genet, 2014
We also identified 12 possibly pathogenic DNMs in genes (HNRNPU, WAC, RYR2, SET, EGR1, MYH10, EIF2C1, COL4A3BP, CHMP2A, PPP1CB, VPS4A, PPP2R2B) that have not previously been causally linked to ID.
Phosphoprotein phosphatase 1 complexes in spermatogenesis.
Fardilha et al., Aveiro, Portugal. In Curr Mol Pharmacol, 2013
Three genes, PPP1CA, PPP1CB and PPP1CC, encode four PPP1C isoforms, PPP1CA, PPP1CB, PPP1CC1, and PPP1CC2.
"Omics" of human sperm: profiling protein phosphatases.
da Cruz e Silva et al., Aveiro, Portugal. In Omics, 2013
This article examines the "Omics" of human sperm, and reports, for the first time, the identification of three new serine/threonine-protein PPs, PPP1CB, PPP4C, and PPP6C, in human sperm, together with two tyrosine-PPs, MKP1 and PTP1C.
Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia.
Elenitoba-Johnson et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2013
Using paired-end transcriptome sequencing, we identified recurrent and reciprocal RNA chimeras involving yippee like 5 (YPEL5) and serine/threonine-protein phosphatase PP1-beta-catalytic subunit (PPP1CB) in CLL.
Trends in the eradication rates of Helicobacter pylori infection for eleven years.
Jang et al., Ch'unch'ŏn, South Korea. In World J Gastroenterol, 2013
We also assessed the eradication rates of 1 wk second-line therapy with a quadruple standard regimen (PPI b.i.d., tripotassium dicitrate bismuthate 300 mg q.i.d., metronidazole 500 mg t.i.d., and tetracycline 500 mg q.i.d.) after the failure of the first-line therapy.
Tandem affinity purification in transgenic mouse embryonic stem cells identifies DDOST as a novel PPP1CC2 interacting protein.
Varmuza et al., Toronto, Canada. In Biochemistry, 2013
In mammals, there are four PP1 isoforms, the ubiquitously expressed PPP1CA, PPP1CB, and PPP1CC1, and the testis specific splice isoform PPP1CC2.
Effects of Dietary Fat Types on Growth Performance, Pork Quality, and Gene Expression in Growing-finishing Pigs.
Choi et al., Suwŏn, South Korea. In Asian-australas J Anim Sci, 2012
In particular, the genes encoding the protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A) and the catalytic subunit of protein phosphatase 1, beta isoform (PPP1CB) showed the highest expression level in the olive oil group (respectively, p<0.05, p<0.001).
Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection.
Sassatelli et al., Reggio nell'Emilia, Italy. In World J Gastroenterol, 2012
Patients who were still positive to UBT were recommended a second-line therapy (PPI b.i.d.
Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling.
Schulz et al., Jena, Germany. In J Biol Chem, 2011
Protein phosphatase 1beta (PP1beta) is identified as a phosphatase for the cluster of phosphorylated threonines ((353)TTETQRT(359)) within the sst(2A) somatostatin receptor carboxyl terminus that mediates beta-arrestin binding using siRNA knock-down screening.
Helicobacter pylori eradication therapy in obese patients undergoing gastric bypass surgery--fourteen days superior to seven days?
Martins et al., Feira, Portugal. In Obes Surg, 2011
Since 2006, 279 patients (Group B) were treated with a similar 14-days drug regimen-PPI b.i.d., CL 500 mg b.i.d., and AMX 1,000 mg b.i.d.
Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.
Shen et al., Shenyang, China. In Melanoma Res, 2011
PPP1CB is over expressed in malignant melanoma.
Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1.
Csortos et al., Debrecen, Hungary. In Biochimie, 2011
Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c.
Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repair.
Yung et al., Taiwan. In Mol Biol Cell, 2010
serine/threonine protein phosphatase PP1beta is a physiological Nucleophosmin (NPM) phosphatase under both the genotoxic stress and growth conditions.
Identification and characterization of a novel human PP1 phosphatase complex.
Skalnik et al., Indianapolis, United States. In J Biol Chem, 2010
mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1) has a role in the regulation of chromatin structure during the transition from mitosis into interphase
The ordering of expression among a few genes can provide simple cancer biomarkers and signal BRCA1 mutations.
Geman et al., Baltimore, United States. In Bmc Bioinformatics, 2008
In the BRCA1 study, RXA yields high accuracy with a simple decision rule: in tumors carrying mutations, the expression of a "reference gene" falls between the expression of two differentially expressed genes, PPP1CB and RNF14.
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