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Protein phosphatase, EF-hand calcium binding domain 2

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PP7, p38, ROD, V1a, AGE
Papers on PPEF-2
Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation.
Asthma BRIDGE consortium et al., Boston, United States. In Plos One, 2013
Four additional genes, XPNPEP1, PPEF2, SMPD3 and CRYGN, were nominally associated in at least one replication group.
Support for the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families.
Tsuang et al., Seattle, United States. In Jama Psychiatry, 2013
Another pedigree transmitted a missense substitution in PPEF2, encoding a calmodulin-binding protein phosphatase, which we show influences mGluR5 levels.
Protein phosphatase with EF-hand domains 2 (PPEF2) is a potent negative regulator of apoptosis signal regulating kinase-1 (ASK1).
Andreeva et al., Chicago, United States. In Int J Biochem Cell Biol, 2010
Data suggest that, despite structural divergence, PPEF and PP5 phosphatases may share common interacting partners and functions.
Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology.
Lemmon et al., Miami, United States. In Mol Syst Biol, 2010
The protein kinase N2 (PKN2) and choline kinase alpha (CHKA) kinases, and the phosphatases PPEF2 and SMPD1, have little or no established functions in neuronal function, but were sufficient to promote neurite growth.
Protein Ser/Thr phosphatases PPEF interact with calmodulin.
Bennett et al., Grenoble, France. In Biochem Biophys Res Commun, 2002
We found that entire human PPEF2 interacts with CaM in the in vivo tests and that its N-terminal domain binds to CaM in a Ca(2+)-dependent manner with nanomolar affinity in vitro.
Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2).
Nathans et al., Baltimore, United States. In Mol Cell Biol, 2001
Two vertebrate rdgC homologs, PPEF-1 and PPEF-2, have been identified.
Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.
Nathans et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 1997
By a combination of large-scale sequencing of human retina cDNA clones and searches of expressed sequence tag and genomic DNA databases, we have identified two sequences in mammals [Protein Phosphatase with EF-hands-1 and 2 (PPEF-1 and PPEF-2)] and one in Caenorhabditis elegans (PPEF) that closely resemble rdgC.
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