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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

PPA2 Ppa2p

PPase, ppa2
The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: pyrophosphatase, ACID, ATPase, CAN, HAD
Papers on PPase
Fluorescent and Colorimetric Dual-Readout Assay for Inorganic Pyrophosphatase with Cu(2+)-Triggered Oxidation of o-Phenylenediamine.
Yang et al., Changchun, China. In Anal Chem, Feb 2016
We demonstrate a rationally designed fluorescent and colorimetric dual-readout strategy for the highly sensitive, quantitative determination of inorganic pyrophosphatase (PPase) activity, a key hydrolytic enzyme involved in a variety of metabolic processes.
Nitrogen use efficiency is mediated by vacuolar nitrate sequestration capacity in roots of Brassica napus.
Ismail et al., Pensacola, United States. In Plant Physiol, Feb 2016
We found that activities of V-ATPase and V-PPase, the two tonoplast proton-pumps, were significantly lower in roots of the high-NUE genotype (Xiangyou15) than in the low-NUE genotype (814); and consequently, less vacuolar NO3- was retained in roots of Xiangyou15.
Vacuolar compartmentalization as indispensable component of heavy metal detoxification in plants.
Mimura et al., Shimla, India. In Plant Cell Environ, Feb 2016
It depends on two vacuolar pumps (V-ATPase and V-PPase) and a set of tonoplast transporters which are directly driven by proton motive force, and primary ATP-dependent pumps.
Maize ZmVPP5 is a truncated Vacuole H(+) -PPase that confers hypersensitivity to salt stress.
Song et al., Shanghai, China. In J Integr Plant Biol, Feb 2016
In this study, we functionally characterized maize vacuole H(+) -PPase 5 (ZmVPP5), a truncated VPP in the maize genome.
H(+)-pyrophosphatase from Salicornia europaea enhances tolerance to low phosphate under salinity in Arabidopsis.
Li et al., Beijing, China. In Plant Signal Behav, Jan 2016
Here, we investigated the potential role that the H(+)- PPase could play in optimizing P use efficiency under salinity in plants.
Molecular Cloning, Expression Analysis, and Functional Characterization of the H(+)-Pyrophosphatase from Jatropha curcas.
Zou et al., Kunming, China. In Appl Biochem Biotechnol, Jan 2016
UNASSIGNED: H(+)-pyrophosphatase (H(+)-PPase) is a primary pyrophosphate (PPi)-energized proton pump to generate electrochemical H(+) gradient for ATP production and substance translocations across membranes.
Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.
Sodeoka et al., Wako, Japan. In Acc Chem Res, Jun 2015
We considered that core structures having structural and electronic features similar to those of PPase substrates, phosphate esters, would be a reasonable choice.
Proton/sodium pumping pyrophosphatases: the last of the primary ion pumps.
Goldman et al., Taiwan. In Curr Opin Struct Biol, 2014
The recent structures of two M-PPases, the Vigna radiata H(+)-pumping M-PPase and Thermotoga maritima Na(+)-pumping M-PPase, provide the basis for understanding the functional data.
Chalk5 encodes a vacuolar H(+)-translocating pyrophosphatase influencing grain chalkiness in rice.
He et al., Wuhan, China. In Nat Genet, 2014
Chalk5 encodes a vacuolar H(+)-translocating pyrophosphatase (V-PPase) with inorganic pyrophosphate (PPi) hydrolysis and H(+)-translocation activity.
Inorganic pyrophosphatases: one substrate, three mechanisms.
Goldman et al., Helsinki, Finland. In Febs Lett, 2013
The structures of the H(+)-pumping mung bean PPase and the Na(+)-pumping Thermotoga maritima PPase solved last year revealed an entirely novel membrane protein containing 16 transmembrane helices.
Improvement of phosphorus efficiency in rice on the basis of understanding phosphate signaling and homeostasis.
Lian et al., Hangzhou, China. In Curr Opin Plant Biol, 2013
SPX-domain containing proteins and the type I H(+)-PPase AVP1 involved in the maintenance and utilization of the internal phosphate.
The structure and catalytic cycle of a sodium-pumping pyrophosphatase.
Goldman et al., Helsinki, Finland. In Science, 2012
The 2.6-angstrom structure of Thermotoga maritima M-PPase in the resting state reveals a previously unknown solution for ion pumping.
Crystal structure of a membrane-embedded H+-translocating pyrophosphatase.
Sun et al., Taiwan. In Nature, 2012
Here we report the crystal structure of a Vigna radiata H(+)-PPase (VrH(+)-PPase) in complex with a non-hydrolysable substrate analogue, imidodiphosphate (IDP), at 2.35 Å resolution.
Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.
Jimenez et al., Sevilla, Spain. In Genetics, 2010
PP2A-Pab1 may be involved in coordinating polar growth and cytokinesis.
Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes.
Moreno et al., Athens, United States. In Philos Trans R Soc Lond B Biol Sci, 2010
While its matrix contains enzymes related to poly P metabolism, the membrane of the acidocalcisomes has a number of pumps (Ca(2+)-ATPase, V-H(+)-ATPase, H(+)-PPase), exchangers (Na(+)/H(+), Ca(2+)/H(+)), and at least one channel (aquaporin).
Ocadaic acid retains caveolae in multicaveolar clusters.
Botos et al., Budapest, Hungary. In Pathol Oncol Res, 2009
We think that PP2A can be one of the key components to regulate the fusion of various endocytotic compartments and /or the trafficking along the microtubules.
An H+ P-ATPase on the tonoplast determines vacuolar pH and flower colour.
Quattrocchio et al., Amsterdam, Netherlands. In Nat Cell Biol, 2008
In endomembrane compartments, pH is regulated by vacuolar H(+)-ATPase (V-ATPase), which, in plants, act together with H(+)-pyrophosphatases (PPase), whereas distinct P-type H(+)-ATPases in the cell membrane control the pH in the cytoplasm and energize the plasma membrane.
Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes.
Johansson et al., Stockholm, Sweden. In Genomics, 2006
No pathogenic mutations were identified in the PPA2 gene in patients with mitochondrial DNA depletion syndromes (MDS).
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